scholarly journals Hashimoto’s Thyroiditis And Cancer: A Review

10.3823/2504 ◽  
2017 ◽  
Vol 10 ◽  
Author(s):  
Rita Hajj Boutros ◽  
Ibrahim Salti
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
The Other ◽  
Hashimoto's Thyroiditis ◽  
Papillary Thyroid ◽  
Fine Needle Aspirate ◽  
Thyroid Lymphoma ◽  
Primary Thyroid Lymphoma ◽  
The Relationship ◽  
Existing Data

Background: No consensus exists on the association between Hashimoto’s thyroiditis (HT) and cancer. To resolve this controversy, this review aimed to evaluate the relationship between the two conditions. Methods: Using Pub-Med database, we searched studies relevant to the topic focusing on the association between HT and Papillary Thyroid Cancer (PTC), as well as the association between HT and Primary Thyroid Lymphoma (PTL). Findings: Both HT and PTC are common worldwide, and the two conditions may be closely related. However, the relationship remains controversial. Some studies found that PTC coexisted with HT 2.8-fold more frequently, with variable prevalence ranging from 0.5 to 30%. In contrast to surgical and pathological series that suggested a positive correlation between the two diseases and even a cause-and-effect relationship, the other studies evaluating fine-needle aspirate specimens did not find a statistically significant correlation. On the other hand, the relationship between PTL and HT appears well established. Conclusion: The existing data provide inconsistent evidence favoring a causal relationship between HT and PTC. Prospective studies are needed to further elucidate the relationship. However patients with HT are at risk for PTL. Therefore careful observation and follow-up of HT patients is recommended.

scholarly journals Development of Primary Thyroid Lymphoma during an Ultrasonographic Follow-up of Hashimoto's Thyroiditis: A Report of 9 Cases

2016 ◽  
Vol 55 (8) ◽  
pp. 943-948 ◽  
Author(s):  
Tetsuya Mizokami ◽  
Katsuhiko Hamada ◽  
Tetsushi Maruta ◽  
Kiichiro Higashi ◽  
Hiroto Yamashita ◽  
...  
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Lymphoma ◽  
Primary Thyroid Lymphoma

scholarly journals Contrast-Enhanced Ultrasound in the Differential Diagnosis of Primary Thyroid Lymphoma and Nodular Hashimoto’s Thyroiditis in a Background of Heterogeneous Parenchyma

2021 ◽  
Vol 10 ◽  
Author(s):  
Lulu Yang ◽  
Haina Zhao ◽  
Yushuang He ◽  
Xianglan Zhu ◽  
Can Yue ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Hashimoto’S Thyroiditis ◽  
Diagnostic Performance ◽  
Roc Curves ◽  
Hashimoto's Thyroiditis ◽  
Imaging Features ◽  
Contrast Enhanced Ultrasound ◽  
Thyroid Lymphoma ◽  
Contrast Enhanced ◽  
Primary Thyroid Lymphoma

ObjectiveTo investigate the diagnostic performance of contrast-enhanced ultrasound (CEUS) in the differentiation of primary thyroid lymphoma (PTL) and nodular Hashimoto’s thyroiditis (NHT) in patients with background of heterogeneous diffuse Hashimoto’s thyroiditis (HT).MethodsSixty HT patients with 64 thyroid nodules (31 PTL and 33 NHT) who had undergone CEUS examination were included in this study. With histopathological results as the reference, we evaluated the imaging features of each nodule on both conventional ultrasonography (US) and CEUS. Quantitative CEUS parameters including peak intensity (PI), time to peak (TTP), and area under the time–intensity curve (AUC) were gathered in the nodule and background parenchyma. The ratio indexes of theses parameters were calculated by the ratio of the lesion and the corresponding thyroid parenchyma. Logistic regression and receiver operating characteristic (ROC) curves analyses of valuable US indicators were further preformed to evaluate the diagnostic capability of CEUS in discrimination of PTL and NHT.ResultsAmong all the observed US imaging features and CEUS parameters, 10 indicators showed significant differences between PTL and NHT (all P < 0.05). All the significant indicators were ranked according to the odds ratios (ORs). Eight of them were CEUS associated including imaging features of enhancement pattern, degree, homogeneity, and quantification parameters of PI, AUC, ratios of PI, AUC, and TTP, while indicators on conventional US, including vascularity and size ranked the last two with ORs less than 3. The five single CEUS parameters showed good diagnostic performance in diagnosis of PTL with areas under ROC curves of 0.72–0.83 and accuracies of 70.3–75.0%. The combination of CEUS imaging features and the ratios of PI, AUC, and TTP demonstrated excellent diagnostic efficiency and achieved area under ROC curve of 0.92, which was significantly higher than any of the five single parameters (all P < 0.05), with a sensitivity of 83.9%, specificity of 87.9%, and accuracy of 85.9%.ConclusionsCEUS is an efficient diagnostic tool in the differential diagnosis of PTL and NHT for patients with diffuse HT. Conjoint analysis of CEUS imaging features and quantification parameters could improve the diagnostic values.

Association of Hashimoto’s Thyroiditis and Burkitt Lymphoma: A Rare Condition to Be Considered

Praxis ◽  
2021 ◽  
Vol 110 (14) ◽  
pp. 812-815
Author(s):  
Dea Degabriel ◽  
Alberto Cerutti ◽  
Laura Caramanica ◽  
Alessandro Viganò ◽  
and Tanja Fusi-Schmidhauser
Keyword(s):  
Weight Loss ◽  
Case Report ◽  
Hashimoto’S Thyroiditis ◽  
Rare Condition ◽  
Hashimoto's Thyroiditis ◽  
Low Grade ◽  
Thyroid Lymphoma ◽  
Thyroid Mass ◽  
Primary Thyroid Lymphoma ◽  
Rule Out

Abstract. We present the case of a 72-year-old woman who was diagnosed with Hashimoto’s thyroiditis and who developed a low-grade fever, fatigue, and weight loss that prompted to perform a thyroid biopsy to rule out an underlying primary thyroid lymphoma. This case report offers the opportunity to review the association between Hashimoto’s thyroiditis and primary thyroid lymphoma. Furthermore, it underlines the importance of considering the diagnosis of lymphoma when a thyroid mass is found in patients with an underlying Hashimoto’s disease, as the timely management is essential for survival with this rare thyroid condition.

Outstanding Combination of Primary Thyroid Lymphoma, Papillary Carcinoma, and Hashimoto's Thyroiditis

CHEST Journal ◽  
2014 ◽  
Vol 145 (3) ◽  
pp. 292A
Author(s):  
Francina Bolanos ◽  
Emmanuel Peña Gomezportugal ◽  
Enrique Guzman del alba ◽  
Patricio Santillán Doherty ◽  
Fortunato Juarez
Keyword(s):  
Papillary Carcinoma ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Lymphoma ◽  
Primary Thyroid Lymphoma

scholarly journals Concomitant thyroid Malt lymphoma and papillary thyroid carcinoma

2010 ◽  
Vol 54 (4) ◽  
pp. 425-428 ◽  
Author(s):  
Giulianno Molina de Melo ◽  
Danilo Anunciatto Sguilar ◽  
Cyntia Moniz Figueira Petiti ◽  
André Gustavo Gumz Eichstaedt ◽  
Rogério Ramos Caiado ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Male Patient ◽  
Malt Lymphoma ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Papillary Thyroid

The objective of this study was to describe the rare thyroid MALT lymphoma concomitant with papillary thyroid carcinoma in a male patient who was submitted to total thyroidectomy. Treatment and follow-up issues are addressed. Male patient complains of fast thyroid enlargement without lymphadenophaty and normal clinical exams. Total thyroidectomy was indicated and performed without any complications. The pathology showed multicentric papillary thyroid carcinoma, concomitant thyroid MALT lymphoma and Hashimoto's thyroiditis. The immunohistochemistry assay was positive for CD 20, CD 43, CD 79, AE1/AE3. The staging studies showed no evidence of both metastasis, Ann Harbor stage IE, without B symptoms. After RIT no further radiotherapy or chemotherapy was indicated. Nowadays the thyroglobulin is undetectable, without recurrences at two years of follow-up. It was concluded that primary thyroid MALT lymphoma is uncommon being the papillary thyroid carcinoma more frequent. Both occurring concomitantly is very rare and the treatment has to prioritize the tumor of worst prognosis at the discovery moment.

scholarly journals Hashimoto’s thyroiditis and primary thyroid lymphoma

QJM ◽  
2020 ◽  
Vol 113 (9) ◽  
pp. 691-692
Author(s):  
Y Otsuka ◽  
M Yasuda ◽  
K Tokumasu ◽  
K Hasegawa ◽  
F Otsuka
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Lymphoma ◽  
Primary Thyroid Lymphoma

Coexistence of Differentiated Thyroid Carcinoma With Primary Thyroid Lymphoma in a Background of Hashimoto's Thyroiditis

2011 ◽  
Vol 29 (25) ◽  
pp. e709-e712 ◽  
Author(s):  
Evangeline Vassilatou ◽  
Theofanis Economopoulos ◽  
Marinella Tzanela ◽  
Dimitra Rontogianni ◽  
Petros Karakitsos ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Hashimoto’S Thyroiditis ◽  
Differentiated Thyroid Carcinoma ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Lymphoma ◽  
Primary Thyroid Lymphoma

scholarly journals The Recovery of Thyroid Function in Low-Risk Papillary Thyroid Cancer After Lobectomy: A 3-Year Follow-Up Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Yi Dou ◽  
Yingji Chen ◽  
Daixing Hu ◽  
Xinliang Su
Keyword(s):  
Risk Factors ◽  
Thyroid Function ◽  
Hashimoto’S Thyroiditis ◽  
Low Risk ◽  
Hashimoto's Thyroiditis ◽  
First Year ◽  
Papillary Thyroid ◽  
Normal Thyroid ◽  
Normal Thyroid Function

PurposeManagement strategies after lobectomy for low-risk papillary thyroid carcinoma (PTC) are controversial. This study aimed to identify the proportion of patients among low-risk PTC patients who do not require hormone replacement therapy and to evaluate the risk factors for postoperative hypothyroidism after lobectomy.Patients and MethodsThe records of 190 PTC patients who underwent thyroid lobectomy from January 2017 to December 2018 were retrospectively reviewed. Clinicopathological characteristics and follow-up data were collected. Univariate and multivariate analyses were performed to identify the risk factors associated with postoperative hypothyroidism and the recovery of thyroid function.ResultsIn summary, 74.21% of patients (141/190) had normal thyroid function without levothyroxine supplementation, while 40.53% (77/190) developed temporary or permanent hypothyroidism. Multivariate analysis indicated that higher preoperative thyroid-stimulating hormone (TSH) levels (>2.62 mIU/L), Hashimoto’s thyroiditis (HT), and right lobectomy were associated with hypothyroidism (all P<0.05). The Area Under Curve (AUC) by logistic analysis was 0.829. Twenty-eight (28/77, 36.4%) patients recovered to the euthyroid state in the first year after surgery, and this recovery was significantly associated with preoperative TSH level. Forty-nine (49/77, 63.6%) patients developed persistent hypothyroidism. The thyroid function of most patients (11/28, 39.3%) recovered in the third month after surgery.ConclusionPatients with a lower level of preoperative TSH, with left lobectomy and without Hashimoto’s thyroiditis had a higher chance of normal thyroid function within the first year after lobectomy. The recovery of thyroid function was associated with the level of preoperative TSH.

scholarly journals Primary Thyroid Lymphoma: A Clinicopathologic Study of 9 Cases and Review of the Literature

2021 ◽  
Author(s):  
Wei-wei Wang ◽  
Li-jing Pan ◽  
Shan-wei Liao ◽  
Xiao-cong Zhou
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Previous History ◽  
Treatment Protocol ◽  
Staging System ◽  
Surgical Excision ◽  
Clinicopathological Characteristics ◽  
Good Prognosis ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Lymphoma ◽  
Primary Thyroid Lymphoma

Abstract Background: Primary thyroid lymphoma（PTL）is extremely rare, thus the dilemma of diagnosis and treatment persists and prognosis remain incompletely understood. Materials and methods: The clinicopathological characteristics, treatment outcomes and prognoses of 9 consecutive primary thyroid lymphoma patients were analyzed retrospectively. Data such as age, gender, presence of Hashimoto’s thyroiditis (HT), treatment protocol, pathologic results and survival status were evaluated. Stage was determined according to the Ann Arbor staging system.Results: They were mostly females with female to male ratio of 1.25：1. The 9 patients ranged in age from 15 to 77 years, with a median age of 63 year. Most of them（7/9）were older than 40 year. A previous history of Hashimoto’s thyroiditis (HT) was observed in 4 patients. All of the nine patients were non-Hodgkin lymphoma（NHL）, eight patients were B cell NHL and one patient was T cell NHL. All patients were treated with surgical excision and most patients received 5-7 circle of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) based chemotherapy post-operation only. Conclusions: The majority of them had good prognosis. Except two lost cases, 85%（6/7）of patients had a survival period of more than 5 years.

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