Neither boosted elvitegravir nor darunavir with emtricitabine/tenofovir disoproxil fumarate increase insulin resistance in healthy volunteers: results from the STRIBILD-IR study

2016 ◽  
Vol 21 (7) ◽  
pp. 627-631 ◽  
Author(s):  
Christoph D Spinner ◽  
Kristina E Kern ◽  
Alexander Zink ◽  
Eva Wolf ◽  
Annamaria Balogh ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Healthy Volunteers ◽  
Tenofovir Disoproxil Fumarate ◽  
Increase Insulin Resistance ◽  
Ir Study

Effects of antiretroviral combination therapies F/TAF, E/C/F/TAF and R/F/TAF on insulin resistance in healthy volunteers: The TAF-IR Study

2018 ◽  
Vol 23 (7) ◽  
pp. 629-632 ◽  
Author(s):  
Christoph D Spinner ◽  
Sebastian Schulz ◽  
Ulrike Bauer ◽  
Jochen Schneider ◽  
Johanna Bobardt ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Healthy Volunteers ◽  
Combination Therapies ◽  
Ir Study

Does parity increase insulin resistance during pregnancy?

2005 ◽  
Vol 22 (11) ◽  
pp. 1574-1580 ◽  
Author(s):  
G. Seghieri ◽  
A. Bellis ◽  
R. Anichini ◽  
L. Alviggi ◽  
F. Franconi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Increase Insulin Resistance

scholarly journals Metabolic Adaptations to Dexamethasone-Induced Insulin Resistance in Healthy Volunteers

2003 ◽  
Vol 11 (5) ◽  
pp. 625-631 ◽  
Author(s):  
Nathalie Nicod ◽  
Vittorio Giusti ◽  
Christine Besse ◽  
Luc Tappy
Keyword(s):  
Insulin Resistance ◽  
Healthy Volunteers ◽  
Metabolic Adaptations

scholarly journals Lack of Pharmacokinetic Drug Interaction between Tenofovir Disoproxil Fumarate and Nelfinavir Mesylate

2005 ◽  
Vol 49 (10) ◽  
pp. 4386-4389 ◽  
Author(s):  
Marta Boffito ◽  
Anton Pozniak ◽  
Brian P. Kearney ◽  
Christopher Higgs ◽  
Anita Mathias ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Healthy Volunteers ◽  
Tenofovir Disoproxil Fumarate ◽  
Time Curve ◽  
Once Daily ◽  
Dosing Interval ◽  
Pharmacokinetic Drug Interaction ◽  
Nelfinavir Mesylate ◽  
Pharmacokinetic Drug

ABSTRACT A study explored the pharmacokinetics of tenofovir (300 mg administered once daily) and nelfinavir (1,250 mg twice daily) when coadministered in 29 healthy volunteers. Tenofovir, nelfinavir, and M8 pharmacokinetics was unaltered when tenofovir and nelfinavir were coadministered, and tenofovir administration did not affect the M8/nelfinavir area under the concentration-versus-time curve over the dosing interval (AUCtau) ratio. No interaction between tenofovir and nelfinavir was observed.

scholarly journals Effects of bee propolis on FBG, HbA1c and insulin resistance in healthy volunteers

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Fawaz A Alassaf ◽  
Mahmood H M Jasim ◽  
Mohanad Alfahad ◽  
Mohannad E Qazzaz ◽  
Mohammed N Abed ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Healthy Volunteers

scholarly journals Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids

2003 ◽  
Vol 89 (3) ◽  
pp. 365-374 ◽  
Author(s):  
Louise M. Goff ◽  
Gary S. Frost ◽  
Gavin Hamilton ◽  
E. Louise Thomas ◽  
Waljit S. Dhillo ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Healthy Volunteers ◽  
Dietary Intervention ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Resonance Spectroscopy ◽  
Sensitivity Index ◽  
Intramyocellular Lipids ◽  
Post Intervention

Subjects with insulin resistance have been shown to have higher storage levels of intramyocellular lipid (IMCL) than their insulin-sensitive counterparts. It has been proposed that elevated IMCL stores may be the main cause of insulin resistance. The aim of the present study was to ascertain whether there is a causal relationship between IMCL storage and insulin resistance. IMCL storage was assessed using magnetic resonance spectroscopy and insulin sensitivity was assessed by performing an oral glucose tolerance test. A 4-week intervention of reduction of dietary glycaemic index was used to manipulate insulin sensitivity in a cohort of healthy volunteers; the effects of this intervention on IMCL were measured after 4 weeks of intervention. Significant improvements in the insulin sensitivity index occurred following the dietary intervention (baseline 7·8 (sem 1·11) v. post-intervention 9·7 (sem 1·11), P=0·02). However, there were no changes in IMCL storage levels, suggesting that insulin sensitivity can be manipulated independently of IMCL. This suggests that in healthy volunteers, insulin sensitivity is independent of IMCL storage and the high storage levels that have been found in insulin-resistant subjects may occur as a consequence rather than a cause of insulin resistance.

Sign in / Sign up

Export Citation Format

Share Document