scholarly journals Pathobiological role of advanced glycation endproducts via mitogen-activated protein kinase dependent pathway in the diabetic vasculopathy

2008 ◽  
Vol 40 (4) ◽  
pp. 398 ◽  
Author(s):  
Young Won Yoon ◽  
Tae Soo Kang ◽  
Byoung Kwon Lee ◽  
Woochul Chang ◽  
Ki-Chul Hwang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Advanced Glycation Endproducts ◽  
Mitogen Activated Protein Kinase ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Diabetic Vasculopathy ◽  
Mitogen Activated Protein ◽  
Dependent Pathway

PO9-235 PATHOBIOLOGICAL ROLE OF ADVANCED GLYCATION ENDPRODUCTS VIA MAPK DEPENDENT PATHWAY

2007 ◽  
Vol 8 (1) ◽  
pp. 75
Author(s):  
T.S. Kang ◽  
H.M. Kwon ◽  
Y.W. Yoon ◽  
S. Rim ◽  
B.K. Hong ◽  
...  
Keyword(s):  
Advanced Glycation Endproducts ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Dependent Pathway

scholarly journals The Immune Tolerance Role of the HMGB1-RAGE Axis

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 564
Author(s):  
Haruki Watanabe ◽  
Myoungsun Son
Keyword(s):  
Immune Responses ◽  
Immune Tolerance ◽  
Lupus Erythematosus ◽  
Advanced Glycation Endproducts ◽  
High Mobility ◽  
Chromatin Binding ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Extracellular Milieu

The disruption of the immune tolerance induces autoimmunity such as systemic lupus erythematosus and vasculitis. A chromatin-binding non-histone protein, high mobility group box 1 (HMGB1), is released from the nucleus to the extracellular milieu in particular environments such as autoimmunity, sepsis and hypoxia. Extracellular HMGB1 engages pattern recognition receptors, including Toll-like receptors (TLRs) and the receptor for advanced glycation endproducts (RAGE). While the HMGB1-RAGE axis drives inflammation in various diseases, recent studies also focus on the anti-inflammatory effects of HMGB1 and RAGE. This review discusses current perspectives on HMGB1 and RAGE’s roles in controlling inflammation and immune tolerance. We also suggest how RAGE heterodimers responding microenvironments functions in immune responses.

scholarly journals Zamzam water protects cancer cells from chemotherapy-induced apoptosis via mitogen-activated protein kinase-dependent pathway

2019 ◽  
Vol 118 ◽  
pp. 109376
Author(s):  
Abdul Khalid Siraj ◽  
Rafia Begum ◽  
Roxanne Melosantos ◽  
Wafaa Albalawy ◽  
Jehan Abboud ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cancer Cells ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Induced Apoptosis ◽  
Dependent Pathway
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