scholarly journals Inflammatory Pseudotumor/Inflammatory Myofibroblastic Tumor of Spleen – A Case Report

2020 ◽  
Vol 8 (C) ◽  
pp. 66-70
Author(s):  
Rubens Jovanovic ◽  
Aleksandar Eftimov ◽  
Svetozar Antovic ◽  
Ognen Kostovski ◽  
Bojan Labachevski ◽  
...  
Keyword(s):  
Case Report ◽  
Microscopic Examination ◽  
Inflammatory Myofibroblastic Tumor ◽  
Inflammatory Pseudotumor ◽  
Plasma Cells ◽  
Unknown Origin ◽  
Inflammatory Cells ◽  
Genetic Changes ◽  
Secondary Neoplasm ◽  
Primary Neoplasm

BACKGROUND: Splenic inflammatory pseudotumor (IPT)/inflammatory myofibroblastic tumor (IMT) is a rare pseudotumor/tumor of unknown origin, which is usually benign, although atypical and aggressive cases have been reported. It is a lesion composed of proliferated myofibroblastic cells (hence IMT by some authors) with admixed pleomorphic inflammatory cells of varying proportions. CASE REPORT: Herein, we report a case of 61-year-old male patient with ill-defined abdominal discomfort and no other symptoms and signs. Clinical and imaging investigations revealed a mass in the spleen that was equivocally interpreted as secondary neoplasm, although primary neoplasm of the spleen was not excluded by the radiologists. Splenectomy was performed and on gross examination a well demarcated greyish-livid tumor measuring 3.5 cm × 3 cm × 3 cm was discovered. Microscopic examination showed proliferation of loosely arranged spindle cells admixed with inflammatory cells (histiocytes, lymphocytes, neutrophils, eosinophils, occasional plasma cells, and/or plasmacytoid cells) with varying density and multifocal clustering, multifocal hemorrhage, and fibrinoid-like deposition. We performed additional histochemical and immunohistochemical stainings which were consistent with the diagnosis of IPT/IMT. Next-generation sequencing (TruSight Tumor 15) showed common TP53 polymorphism (c.215C>G; p.Pro72Arg) along with several intronic and synonymous single nucleotide variations (SNVs), as well as five low confidence missense SNVs. Sixteen months after the operation the patient has uneventful follow-up. CONCLUSION: Although the incidence of IPT/IMT is low, awareness of its existence is necessary. The prognosis is favorable following splenectomy in most cases. Careful microscopic examination of the specimen is mandatory, due to possible misdiagnosis. We believe that extensive NGS analysis on archive samples would provide more data about the spectrum of possible genetic changes in lesions like IPM/IMT.

scholarly journals Inflammatory myofibroblastic tumor of the larynx

2008 ◽  
Vol 65 (10) ◽  
pp. 779-782
Author(s):  
Zaklina Mijovic ◽  
Dragan Mihailovic ◽  
Milos Kostov
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Tumor Cells ◽  
Inflammatory Myofibroblastic Tumor ◽  
Plasma Cells ◽  
Anterior Commissure ◽  
Inflammatory Cells ◽  
Stellate Cells ◽  
Aggressive Treatment ◽  
Storiform Pattern

Background/Aim. Inflammatory myofibroblastic tumor (IMT) of the larynx is a rare borderline lesion composed of myofibroblastic and inflammatory cells. Case report. We presented a case of 77-year-old male with hoarseness for about three months. Laryngoscopy showed a polypoid tumor originated from the anterior commissure with glottic projection. Grossly, the tumor was 22 ? 15 mm, whitish, oval nodus with firm consistency. Histologically, the lesion was composed of spindled to stellate cells arranged in a fascicular to storiform pattern and inflammatory cells: lymphocytes, histiocytes, plasma cells and neutrophils. The stroma was fibromyxoid and collagenous. Immunohistochemically, tumor cells showed strong positivity for actin and vimentin and negativity for cytokeratin, CD34, S100 and desmin. The proliferation (Ki67) was less than 10%. Conclusion. Inflammatory myofibroblastic tumor may be mistaken as a malignancy and the differential diagnosis can be difficult without immunohistochemistry. It is critical to recognize this uncommon entity to avoid unnecessary aggressive treatment.

Inflammatory myofibroblastic tumor (inflammatory pseudotumor) of the breast. Case report

Apmis ◽  
2005 ◽  
Vol 113 (1) ◽  
pp. 66-9 ◽  
Author(s):  
SENNUR ILVAN ◽  
VAROL CELIK ◽  
MELIH PAKSOY ◽  
ILKNUR CETINASLAN ◽  
ZERRIN CALAY
Keyword(s):  
Case Report ◽  
Inflammatory Myofibroblastic Tumor ◽  
Inflammatory Pseudotumor

Uncommon Coetaneous Histopathological Findings in Radicular Cyst: A Case Report

2020 ◽  
Vol 5 (2) ◽  
pp. 1115-1118
Author(s):  
Shashi Keshwar ◽  
Ashish Shrestha ◽  
Sushmita Shrestha ◽  
Tonia Raut
Keyword(s):  
Case Report ◽  
Squamous Epithelium ◽  
Plasma Cells ◽  
Inflammatory Cells ◽  
Epithelial Lining ◽  
Radicular Cyst ◽  
Histopathological Findings ◽  
Stratified Squamous Epithelium ◽  
Cyst Lining ◽  
Maxillary Region

Radicular cyst is the most common inflammatory cyst of jaw. It arises from the epithelial residues in the periodontal ligaments as a result of pulp infection. Histopathologically radicular cyst lining reveals stratified squamous epithelium with arcade like pattern in early cases or quiescent epithelial lining in long standing cases. The wall of the radicular cyst is fibrous with mixed inflammatory cells infiltrate like neutrophils, plasma cells, lymphocytes and macrophages. There are very few reported cases of juxtaepithelial hyalinization of radicular cyst. Here we report a case of radicular cyst of a 28 year old male who presented with pus discharge from anterior right maxillary region. The cyst was associated with atrophic and tenuous epithelial lining with juxtaepithelial hyalinization along with focal Russell bodies. These findings are uncommoncoeval features of radicular cyst.

scholarly journals Oesophageal pseudotumor: a case report

2017 ◽  
Vol 4 (4) ◽  
pp. 1469
Author(s):  
Sreejayan M. P. ◽  
Arun S.
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Inflammatory Myofibroblastic Tumor ◽  
Inflammatory Pseudotumor ◽  
Soft Tissue Density ◽  
Lower Esophagus ◽  
Immunoglobulin G4 ◽  
Related Disease ◽  
Right Thoracotomy ◽  
History Of

Inflammatory pseudo tumor (IPT) also known as inflammatory myofibroblastic tumor (IMT) is a tumor like mass of inflammatory origin. It is a pseudo sarcomatous lesion that has been reported most commonly in liver, followed by lung, mesentery and omentum but very rarely seen in esophagus. Proliferation of myofibroblastic cells is more in IMT. In IPT it is more of an inflammatory reactive or regenerative entity and has an overlapping with immunoglobulin G4-related disease. Lesion often mimics malignancy. A 20 year old male patient with history of dysphagia, more for liquids, underwent CT thorax, showing dilated oesophagus, with a moderately contrast enhancing eccentric soft tissue density lesion involving mid and lower esophagus extending for a length of 6cm. Patient underwent right thoracotomy, and a 5x3x3cm hard lesion involving lower esophagus was excised. Histopathology pointed towards inflammatory myofibroblastic tumor or inflammatory pseudotumor. Proliferation of myofibroblastic cells is more in IMT. In IPT it is more of an inflammatory reactive or regenerative entity and has an overlapping with immunoglobulin G4-related disease. Lesion often mimics malignancy.

scholarly journals ALK Negative Inflammatory Myofibroblastic Tumor Synchronous with Classical Hodgkin Lymphoma

2019 ◽  
Vol 12 (1) ◽  
pp. 119-125 ◽  
Author(s):  
Letícia Sandoval ◽  
Marcos Vinícius França ◽  
Daniel Sanmartino ◽  
Flávia Zattar Piazera
Keyword(s):  
Case Report ◽  
Hodgkin Lymphoma ◽  
Male Patient ◽  
Inflammatory Myofibroblastic Tumor ◽  
Inflammatory Pseudotumor ◽  
Hodgkin's Lymphoma ◽  
Differential Diagnoses ◽  
Classical Hodgkin Lymphoma ◽  
Review Of Literature ◽  
Medical Assistance

Inflammatory myofibroblastic tumor or inflammatory pseudotumor was first described by Brunn in 1932. Umiker et al. named it so in 1954 for its ability to mimic malignancy clinically and radiologically [Med Pediatr Oncol 2000; 35(5): 484–7]. This tumor, characterized by its rareness, affects mainly the lung and the orbit. Histologically, the tumor is characterized by the presence of fibroblasts, myofibroblasts, polymorphs, lymphocytes, and neutrophils. This case report and review of literature present a male patient, 37 years old, with a bulky mediastinal lesion at the topography of the 4th rib. Histopathology reveals Hodgkin’s Lymphoma (HL) concomitant with inflammatory myofibroblastic tumor (IMT). This report aims to emphasize the relevance of differential diagnoses to a better medical assistance. To the best of our knowledge, a case with this characteristic has never been seen before.

scholarly journals Case Report: Xanthogranulomatous salpingo-oophoritis associated to endometriosis – are these different histologic expressions of the same disease?

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 94
Author(s):  
Ana Portela Carvalho ◽  
Ana Costa Braga ◽  
Hélder Ferreira
Keyword(s):  
Case Report ◽  
Inflammatory Response ◽  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Inflammatory Process ◽  
Plasma Cells ◽  
Inflammatory Cells ◽  
Common Disorder ◽  
Xanthogranulomatous Inflammation ◽  
Large Distortion

Xanthogranulomatous inflammation is characterized by the presence of foamy histiocytes associated with other inflammatory cells like lymphocytes, plasma cells and neutrophils. It is a rare inflammatory process, which has been more frequently described in chronic pyelonephritis and cholecystitis. Xanthogranulomatosis usually triggers a large distortion of the affected organ, which is secondary to the severe inflammatory response that characterizes this type of lesion. Only a few cases of xanthogranulomatous salpingo-oophoritis have been published to date. Here, we report the case of a xanthogranulomatous salpingo-oophoritis in a patient with endometriosis, suffering from chronic pelvic pain and long-standing infertility. The association between endometriosis and xanthogranulomatous inflammation is extremely rare and can possibly represent a severe histologic expression of this common disorder.

scholarly journals Inflammatory myofibroblastic tumor of the urinary bladder: treatment and a two-year monitoring - case report

2021 ◽  
Vol 74 (1-2) ◽  
pp. 41-44
Author(s):  
Stevan Stojanovic ◽  
Zarko Dimitric ◽  
Ivan Levakov ◽  
Mladen Popov ◽  
Sandra Trivunic-Dajko ◽  
...  
Keyword(s):  
Case Report ◽  
Urinary Bladder ◽  
Transurethral Resection ◽  
Inflammatory Myofibroblastic Tumor ◽  
Bladder Tumor ◽  
Inflammatory Pseudotumor ◽  
Histopathological Examination ◽  
Rare Case Report ◽  
Unpleasant Feeling ◽  
First Time

Introduction. Inflammatory myofibroblastic tumor of the bladder or inflammatory pseudotumor is benign in nature. It is also known as a pseudotumor, because it macroscopically mimics infiltrative tumors of the bladder. The first inflammatory pseudotumor ever described was found in the lungs. In the 80s of the last century, it was first described in the urinary bladder. Its etiology is unknown and the incidence is extremely rare. Case Report. We present a case of a 46-year-old man who came to the Emergency Center for the first time due to an unpleasant feeling when urinating, painless hematuria and appearance of blood clots during urination. An urgent diagnosis revealed a tumor mass in the bladder. Additional diagnostics and surgical treatment was performed by transurethral electroresection of the urinary bladder. After the histopathological examination, an inflammatory myofibroblastic tumor of the bladder was diagnosed. The patient was discharged on the third day of admission. On control examinations, the patient underwent only cystoscopy and ultrasonography. No recurrences were observed. Conclusion. A review of the available literature showed that in such cases, after transurethral resection of bladder tumor, most urologists opted for more radical surgical procedures. After a two-year follow-up, we proved that a tumor of the bladder can be kept under control after transurethral resection of bladder tumor, without recurrence, by regular monitoring using ultrasonography and cystoscopy.

Sign in / Sign up

Export Citation Format

Share Document