scholarly journals Pseudomonas aeruginosa inhibits the growth of pathogenic fungi: In vitro and in vivo studies

2014 ◽  
Vol 7 (6) ◽  
pp. 1516-1520 ◽  
Author(s):  
LINGQING XU ◽  
FENG WANG ◽  
YIN SHEN ◽  
HONGYAN HOU ◽  
WEIYONG LIU ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Pathogenic Fungi ◽  
In Vivo Studies

scholarly journals Glycyrrhizin Use for Multi-Drug Resistant Pseudomonas aeruginosa: In Vitro and In Vivo Studies

2019 ◽  
Vol 60 (8) ◽  
pp. 2978
Author(s):  
Linda D. Hazlett ◽  
Sandamali A. Ekanayaka ◽  
Sharon A. McClellan ◽  
Rebecca Francis
Keyword(s):  
Pseudomonas Aeruginosa ◽  
In Vivo Studies ◽  
Drug Resistant

scholarly journals Peptide dendrimers as “lead compounds” for the treatment of chronic lung infections by Pseudomonas aeruginosa in cystic fibrosis patients: in vitro and in vivo studies

2018 ◽  
Vol Volume 11 ◽  
pp. 1767-1782 ◽  
Author(s):  
Arianna Pompilio ◽  
Cristina Geminiani ◽  
Paolo Mantini ◽  
Thissa N Siriwardena ◽  
Ivan Di Bonaventura ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
In Vivo Studies ◽  
Lead Compounds ◽  
Peptide Dendrimers ◽  
Lung Infections

scholarly journals High Therapeutic Index of Factor C Sushi Peptides: Potent Antimicrobials against Pseudomonas aeruginosa

2001 ◽  
Vol 45 (10) ◽  
pp. 2820-2825 ◽  
Author(s):  
Yin Hoe Yau ◽  
Bow Ho ◽  
Nguan Soon Tan ◽  
Miang Lon Ng ◽  
Jeak Ling Ding
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Therapeutic Potential ◽  
Therapeutic Index ◽  
In Vivo Studies ◽  
C Protein ◽  
High Therapeutic Index ◽  
Viable Bacteria ◽  
Factor C

ABSTRACT Factor C protein isolated from the horseshoe crab,Carcinoscorpius rotundicauda, has endotoxin binding capability. Synthetic peptides of 34 amino acids based on the sequence of two regions of factor C (Sushi 1 and Sushi 3) as well as their corresponding mutants exhibited activities against 30 clinical isolates of Pseudomonas aeruginosa. Collectively, all four peptides demonstrated exceptionally effective bactericidal activity againstP. aeruginosa with 90% minimal bactericidal concentrations (MBC90s) in the range of 0.06 to 0.25 μg/ml (16 to 63 nM). Viable bacteria were reduced by 90% after 7 min and were totally eradicated within 40 to 50 min. These peptides are minimally hemolytic against both rabbit and human erythrocytes even at concentrations up to 1,600-fold their MBC90s. Both in vitro and in vivo studies indicate that cytotoxic effects are small even at 1,000-fold their MBC90s. Furthermore, the Sushi peptides are tolerant of high-salt and adverse pH conditions. These findings demonstrate the promising therapeutic potential of the Sushi peptides.

scholarly journals Efficacy of Tachyplesin III, Colistin, and Imipenem against a Multiresistant Pseudomonas aeruginosa Strain

2007 ◽  
Vol 51 (6) ◽  
pp. 2005-2010 ◽  
Author(s):  
Oscar Cirioni ◽  
Roberto Ghiselli ◽  
Carmela Silvestri ◽  
Wojciech Kamysz ◽  
Fiorenza Orlando ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Single Agent ◽  
In Vivo Studies ◽  
Necrosis Factor Alpha ◽  
Serious Infections ◽  
Factor Alpha ◽  
Therapeutic Alternatives ◽  
Time Kill

ABSTRACT An experimental study has been performed to compare the in vitro activity and the in vivo efficacy of tachyplesin III, colistin, and imipenem against a multiresistant Pseudomonas aeruginosa strain. In vitro experiments included MIC determination, time-kill, and synergy studies. For in vivo studies, a mouse model of sepsis has been used. The main outcome measures were bacterial lethality, quantitative blood cultures, and plasma levels of lipopolysaccharide, tumor necrosis factor alpha, and interleukin-6. The combination of tachyplesin III or colistin with imipenem showed in vitro synergistic interaction. A significant increase in efficacy was also observed in vivo: combination-treated groups had significantly lower levels of bacteremia than did groups treated with a single agent. Tachyplesin III combined with imipenem exhibited the highest efficacy on all main outcome measurements. These results highlight the potential usefulness of these combinations and provide therapeutic alternatives for serious infections caused by gram-negative bacteria in the coming years.

Impact of multidrug resistance on the pathogenicity of Pseudomonas aeruginosa: in vitro and in vivo studies

2016 ◽  
Vol 47 (5) ◽  
pp. 368-374 ◽  
Author(s):  
Silvia Gómez-Zorrilla ◽  
Carlos Juan ◽  
Gabriel Cabot ◽  
Mariana Camoez ◽  
Fe Tubau ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Multidrug Resistance ◽  
In Vivo Studies

scholarly journals In vitro and in vivo studies of ME1228, a new parenteral cephalosporin with potent activity against Pseudomonas aeruginosa.

1991 ◽  
Vol 35 (6) ◽  
pp. 1245-1246 ◽  
Author(s):  
S Miyazaki ◽  
Y Miyazaki ◽  
A Tsuji ◽  
M Nishida ◽  
S Goto
Keyword(s):  
Pseudomonas Aeruginosa ◽  
In Vivo Studies
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