scholarly journals Risk factors for new-onset chronic kidney disease in patients who have received a liver transplant

2018 ◽  
Author(s):  
Yuehong Li ◽  
Binbin Li ◽  
Wei Wang ◽  
Jiaxuan Lv
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Liver Transplant ◽  
New Onset

scholarly journals Obesity and kidney disease: Hidden consequences of the epidemic

2017 ◽  
Vol 104 (1) ◽  
pp. 1-14 ◽  
Author(s):  
CP Kovesdy ◽  
S Furth ◽  
C Zoccali ◽  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Healthy Lifestyle ◽  
High Body Mass Index ◽  
The World ◽  
Policy Measures ◽  
Intraglomerular Pressure ◽  
New Onset

Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk factors for new-onset CKD. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long-term. The incidence of obesity-related glomerulopathy has increased tenfold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis, and for a number of malignancies including kidney cancer. This year the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle, and health policy measures that makes preventive behaviors an affordable option.

scholarly journals Fibroblast growth factor 23 and new-onset chronic kidney disease in the general population: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study

2020 ◽  
Vol 36 (1) ◽  
pp. 121-128 ◽  
Author(s):  
Maarten A De Jong ◽  
Michele F Eisenga ◽  
Adriana J van Ballegooijen ◽  
Joline W J Beulens ◽  
Marc G Vervloet ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Fibroblast Growth Factor 23 ◽  
Population Based ◽  
Fibroblast Growth ◽  
Fgf23 Level ◽  
Increased Risk ◽  
All Cause Mortality ◽  
New Onset

Abstract Background Fibroblast growth factor 23 (FGF23), a phosphate-regulating hormone that increases early in the course of chronic kidney disease (CKD), is associated with disease progression in patients with established CKD. Here we aimed to investigate the association between plasma FGF23 and new-onset CKD in the general population. Methods We included 5253 individuals without CKD who participated in the Prevention of Renal and Vascular Endstage Disease study, a prospective, population-based cohort. Multi-variable Cox regression was used to study the association of plasma C-terminal FGF23 with new-onset CKD, defined as a combined endpoint of estimated glomerular filtration rate (eGFR) <60 mL/min/ 1.73 m2, urinary 24-h albumin excretion (UAE) >30 mg/24 h or both, or with all-cause mortality. Results The median baseline FGF23 was 68 [interquartile range (IQR) 56–85] RU/mL, eGFR was 95 ± 13 mL/min/1.73 m2 and UAE was 7.8 (IQR 5.8–11.5)  mg/24 h. After follow-up of 7.5 (IQR 7.2–8.0)  years, 586 participants developed CKD and 214 participants died. A higher FGF23 level was associated with new-onset CKD, independent of risk factors for kidney disease and parameters of bone and mineral homoeostasis {fully adjusted hazard ratio (HR) 1.25 [95% confidence interval (CI) 1.10–1.44] per doubling of FGF23; P = 0.001}. In secondary analyses, FGF23 was independently associated with new-onset eGFR <60 mL/min/1.73 m2 [adjusted HR 1.28 (95% CI 1.00–1.62); P = 0.048] or with UAE >30 mg/24 h [adjusted HR 1.24 (95% CI 1.06–1.45); P = 0.01] individually. A higher FGF23 level was also associated with an increased risk of all-cause mortality [fully adjusted HR 1.30 (95% CI 1.03–1.63); P = 0.03]. Conclusions High FGF23 levels are associated with an increased risk of new-onset CKD and all-cause mortality in this prospective population-based cohort, independent of established CKD risk factors.

scholarly journals Obesity and kidney disease: hidden consequences of the epidemic

2017 ◽  
Vol 59 (1) ◽  
pp. 38-44
Author(s):  
Csaba P Kovesdy ◽  
Susan Furth ◽  
Carmine Zoccali
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Healthy Lifestyle ◽  
High Body Mass Index ◽  
The World ◽  
Policy Measures ◽  
Intraglomerular Pressure ◽  
New Onset

Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for Chronic Kidney Disease. A high body mass index is one of the strongest risk factors for new-onset Chronic Kidney Disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing Chronic Kidney Disease in the long-term. The incidence of obesity-related glomerulopathy has increased ten-fold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis, and for a number of malignancies including kidney cancer. This year the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle and health policy measures that makes preventive behaviors an affordable option.

scholarly journals Anemia and atrial fibrillation as independent risk factors for new-onset chronic kidney disease: the TAMA-MED Project-CKD and AF

2021 ◽  
Author(s):  
Tomohiro Kaneko ◽  
Eitaro Kodani ◽  
Hitomi Fujii ◽  
Risa Asai ◽  
Miyako Seki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Rapid Deterioration ◽  
New Onset

Abstract Background Various risk factors have been identified for the new-onset or rapid deterioration of chronic kidney disease. However, it is thought that many risk factors that have not yet been clarified remain. Methods Based on the results of specific annual health checkups at Tama City (n = 18,383) in 2017 and 2018, we analyzed the factors that cause new-onset chronic kidney disease and the risk factors that rapidly worsen renal function. For new-onset chronic kidney disease, proteinuria and estimated glomerular filtration rate < 60 mL/min/1.73m2 were examined separately. Rapid deterioration of renal function was defined as an estimated glomerular filtration rate of ≥ 25% lower than the previous year. Results Multivariate analysis showed that, in addition to age and impaired glucose tolerance, anemia, and atrial fibrillation were risk factors for the new appearance of proteinuria. Risk factors for a decrease in estimated glomerular filtration rate < 60 mL/min/1.73m2 were age and hyperuricemia. Age, systolic hypertension, urinary protein and urinary occult blood, high triglycerides, and anemia were significant risk factors for the rapid deterioration of renal function in patients with chronic kidney disease stage 3 or later. Conclusions From the results of specific annual health checkups at Tama City, atrial fibrillation, anemia, and hyperuricemia were identified as risk factors for new-onset chronic kidney disease over a short period of 1 year. Anemia was also a factor for the rapid deterioration of kidney function in subjects with renal dysfunction.

Abstract 2152: Close Bidirectional Relationship Between Chronic Kidney Disease and Atrial Fibrillation: The Niigata Preventive Medicine Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Hiroshi Watanabe ◽  
Toru Watanabe ◽  
Shigeru Sasaki ◽  
Kojiro Nagai ◽  
Yoshifusa Aizawa
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Kidney Dysfunction ◽  
Baseline Serum ◽  
The Metabolic Syndrome ◽  
New Onset

Atrial fibrillation (AF) and chronic kidney disease share risk factors including obesity, hypertension, diabetes, and the metabolic syndrome as well as pathophysiologic mechanisms including persistent inflammation and oxidative stress. We tested the hypothesis here that two conditions are risk factors for each other. This is a prospective community-based observational cohort study based upon an annual health check-up in Niigata prefecture, Japan. We studied the association of kidney dysfunction with new-onset AF and the association of AF with development of kidney disease in 235,818 subjects (mean age, 60.9 ± 11.7 years). Development of kidney dysfunction was defined by an elevation of serum creatinine level (≥1.4 mg/dL for men, ≥1.2 mg/dL for women) or an GFR reduction (<60 ml/min/1.73 m 2 ) in subjects without baseline kidney dysfunction. Kidney disease as risk of AF During a follow-up of 5.9 ± 2.4 years, AF developed in 2,947 subjects (1.3%). Baseline serum creatinine and GFR were associated with risk of subsequent AF (adjusted hazard ratios, HRs [95% confidence interval, CI], 1.09 [1.02–1.17] for serum creatinine [1 mg/dL increment] and 1.02 [1.00 –1.03] for GFR [10 ml/min/1.73 m 2 decline]). The HRs for AF increased inversely with GFR: 1.32 (95% CI, 1.08 –1.62) for GFR 30 –59 ml/min/1.73 m 2 and 1.57 (95% CI, 0.89 –2.77) for GFR <30 ml/min/1.73 m 2 . The effect of chronic kidney disease on risk of new-onset AF was significant after eliminating subjects with treated hypertension or diabetes. AF as risk of kidney disease During a 5.9 year follow-up, 7,791 subjects (4.0%) developed kidney dysfunction and 11,307 subjects (5.8%) developed proteinuria. Baseline AF was associated with development of kidney dysfunction (HRs [95% CI], 1.84 [1.30 –2.61] for serum creatinine-based model and 1.77 [1.50 –2.10] for GFR-based model) and proteinuria (HR [95% CI], 2.20 [1.92–2.52]). The association remained significant in subjects without treated hypertension and diabetes. Kidney dysfunction increased the risk of new-onset of AF and AF increased risk of development of kidney disease. This finding supports the concept that the two conditions share common abnormal molecular signaling pathways contributing to their pathogenesis.

scholarly journals Obesity and Kidney Disease: Hidden Consequences of the Epidemic

2017 ◽  
Vol 45 (3) ◽  
pp. 283-291 ◽  
Author(s):  
Csaba P. Kovesdy ◽  
Susan L. Furth ◽  
Carmine Zoccali ◽  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Healthy Lifestyle ◽  
High Body Mass Index ◽  
The World ◽  
Policy Measures ◽  
Intraglomerular Pressure ◽  
New Onset

Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney disease. A high body mass index is one of the strongest risk factors for new-onset chronic kidney disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing chronic kidney disease in the long-term. The incidence of obesity-related glomerulopathy has increased 10-fold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis, and for a number of malignancies including kidney cancer. This year, the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle and health policy measures that make preventive behaviors an affordable option.

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