scholarly journals Expression and influence of pentraxin-3, HbAlc and ApoA1/ApoB in serum of patients with acute myocardial infarction combined with diabetes mellitus type 2

2018 ◽  
Author(s):  
Yanxia Zhu ◽  
Xiaofang Wang ◽  
Weihua Wang ◽  
Hongguang Wang ◽  
Fenglei Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Pentraxin 3

scholarly journals THE RELATIONSHIP BETWEEN CALPROTECTIN AND PARAMETERS OF LIPID AND CARBOHYDRATE METABOLISM, ANTHROPOMETRIC AND INFLAMMATORY PARAMETERS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2

2019 ◽  
Vol 19 (2) ◽  
pp. 16-18
Author(s):  
M. I. Zhuravlova
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Insulin Resistance ◽  
Acute Myocardial Infarction ◽  
Carbohydrate Metabolism ◽  
Diabetes Mellitus Type 2 ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
The Relationship

Nowadays, an acute myocardial infarction is one of the leading causes of mortality among the population. The EHS-DH registry data clearly illustrate the association between the comorbidities and high mortality following acute myocardial infarction during a year period of follow up. The pronounced influence of carbohydrate metabolism disturbances on the survival of such patients has already been reported. The aim of the study was to analyze the immune inflammation relationships based on assessing calprotectin and the parameters of lipid and carbohydrate metabolism, to evaluate the presence and nature of the relationship between these parameters and carbohydrate metabolism parameters based on the study of blood glucose, insulin and insulin resistance (by the indices HOMA, QUICKI, Caro), anthropometric indicators and inflammatory indicators (monocyte and neutrophile levels). Materials and methods. The study included 64 patients (mean age 65, 31 ± 1.62 years) with acute myocardial infarction and concomitant diabetes mellitus type 2. The design of the study included the primary laboratory investigation of patients during the first day since the onset of acute myocardial infarction with the elevation of the ST segment before the initiation of thrombolytic therapy or percutaneous intervention. The direct correlation between the calprotectin concentration and the HOMA insulin resistance index (R = 0.52; p <0.05), insulinemia (R = 0.57; p <0.05), fasting glycaemia (R = 0, 59; p <0.05), as well as inverse correlation relationships between the Caro index (R = 0.68; p <0.05) and the QUICKI index (R = 0.59; p <0.05) were found out. Moreover, a direct correlation between calprotectin and triglyceride levels (R = 0.31; p <0.05), and negative correlation with high density lipoprotein (R = 0.35; p <0.05) was established as well. The level of total cholesterol and low density lipoproteins showed no significant association with the proinflammatory factor (R = 0.12; p> 0.05 and R = 0.18; p> 0.05, respectively). Conclusions. The increase in the body mass index and the activity of serum monocytes and neutrophils is associated with high concentrations of calprotectin that is accompanied by disturbances of carbohydrate homeostasis towards the growth of insulin resistance and changes of lipidograms of proatherrogenic nature.

scholarly journals Complete left bundle branch block as predictor of cardiogenic shock in patient with acute myocardial infarction on the background of diabetes mellitus type 2

2020 ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiogenic Shock ◽  
Left Bundle Branch Block ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Bundle Branch Block

Cardiogenic shock is the leading cause of death in patients with acute myocardial infarction, with high hospital mortality rates ∼80 %. The incidence of cardiogenic shock among myocardial infarction patients is approximately 7 %. Cardiogenic shock patients are found that pre-existing diabetes is associated with an increased risk of cardiogenic shock and it worsens outcomes, with a longer hospital stay. Cardiogenic shock develops approximately twice as often among diabetics as among nondiabetic patients with acute myocardial infarction. Diabetes mellitus and left bundle branch block are predictors of cardiogenic shock complicating acute myocardial infarction. Except for bad prognosis, left bundle branch block can be a marker of a slowly progressing, degenerative, ischemic or non-ischemic cardiac disease, affecting not only the muscle but also the heart conduction system. Immediate diagnosis and management are required. In this article, a clinical case of acute posterior myocardial infarction complicated by complete left bundle branch block and cardiogenic shock in the patient with concomitant diabetes mellitus type 2 is demonstrated. This article emphasizes the priority of referring patients with left bundle branch block to primary percutaneous coronary intervention, usage of more specific ECG criteria for acute coronary syndrome, the role of myocardial infarction biomarker including sensitive assays for cardiac troponins, and bedside echocardiography which may improve diagnostic accuracy and result in timely intervention in such patients. This article also underlines the role of mechanical circulatory support, urgent reperfusion therapy, and strict control of glycemia in the acute phase of myocardial infarction which may contribute to clinical stability of patients with diabetes mellitus and myocardial infarction complicated by cardiogenic shock.

Lipid peroxidation and antioxidant system in patients with acute мyocardial infarction and diabetes mellitus type 2

2015 ◽  
Vol 9 (4) ◽  
pp. 0-0
Author(s):  
Загородняя ◽  
T. Zagorodnyaya ◽  
Корниенко ◽  
E. Kornienko ◽  
Иванов ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Lipid Peroxidation ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Antioxidant System ◽  
Diabetes Mellitus Type 2 ◽  
Coronary Intervention ◽  
Diabetes Mellitus Type

Problems of the treatment of comorbid patients in routine clinical practice remain highly relevant. One of the most common combinations – coronary heart disease and diabetes mellitus type 2. In this article, the authors present their own experience of studying the effects of infusion of the drug &#34;Reamberin&#34; at the stage of percutaneous coronary intervention on the dynamics of indicators of lipid peroxidation in patients with myocardial infarction with diabetes mellitus type 2. This study consists of the examination and treatment analysis of 54 patients, men aged 64,3 ± 6,8 years old with coronary heart disease and clinical manifestations of acute myocardial infarction and concomitant diabetes mellitus type 2. The percutaneous intervention was made of this group of patients. To determine the normal values of the studied parameters, the examination of 34 patients with coronary heart disease without exacerbation (men aged 62,5 ± 4,2 years) with concomitant diabetes mellitus type 2, was carried out. It is found that the development of acute myocardial infarction in patients with diabetes type 2 is accompanied by activation of processes of lipid peroxidation and antioxidant system of blood with a predominance of lipid peroxidation. It is proved that the use of succinic acid drug &#34;Reamberin&#34; at the stage of percutaneous coronary intervention in these patients contributes to the decrease in the intensity of free radical processes and increases the activity of enzymatic antioxidants.

scholarly journals Effect of natural polyphenols on diabetes mellitus (type-2) with myocardial infarction: a double-blind placebo controlled trial

2019 ◽  
Vol 6 (2) ◽  
pp. 351
Author(s):  
Rahul Goyal ◽  
S. Nagtilak ◽  
Vijay Thawani ◽  
Shavetika Jindal
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Diabetes Mellitus Type 2 ◽  
Controlled Trial ◽  
Prognostic Significance ◽  
Vascular Complications ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Double Blind

Background: Diabetes Mellitus Type-2(T2D); is a leading disease in world wide. T2D is a clinical syndrome characterized by hyperglycaemia. Hyperglycemias are caused by an absolute or relative deficiency of insulin and due to insulin resistance. Diabetic patients are highly prone to Reactive Oxygen Species (ROS) and leads to Cardio vascular complications. Several medicines have been recommended to cure T2D; and still discovery of newer drugs are in process. Now a day, the focus of researches in diabetes includes discovery of newer anti-diabetic agents as well as isolating the active compounds from herbal sources. One such herbal source is pomegranate. Pomegranate is polyphenols and antioxidants rich fruit; which has potency to cure T2D and ROS.Methods: A Pomegranate Extract of Whole Fruit (PEWF) was prepared as tablet of 300mg to investigate its effects in patients with T2D. Total 40 participants of either gender with nested cases of T2D with Myocardial Infarction (MI) were included in study. All participants were assigned in two groups (20 each). One group was under “Add On” therapy of PEWF and matching placebos of same colour, shape and size were used as comparator agent for second group (300mg BD for 1 month).Results: Levels of biochemical markers related to T2D were compared to analysed pre and post drug effects by Z test, chi square test and by coefficient of variations. Results highlighted that those participants who were under “add-on” therapy of PEWF showed highly prognostic significance. Thus, PEWF should be consumed in diet as food supplementation.Conclusions: In conclusion, polyphenols and antioxidants rich fruit supplements should be taken in diet for healthy living.

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