Correlation between coronary stenosis and Toll‑like receptors 2 and 4 levels in Chinese Zhuang patients with coronary heart disease

SummaryThe histidin-rich glycoprotein (HRG) may contribute to coronary heart disease as a consequence of its possible thrombophilic properties. To test this hypothesis we have investigated the Pro186/Ser polymorphism of the HRG gene, which is known to strongly affect plasma HRG levels, in a large multicenter case-control study of myocardial infarction (MI). The results failed to demonstrate any association between the polymorphism and MI or angiographically assessed coronary stenosis.

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Modification of the association between smoking status and severity of coronary stenosis by vitamin D in patients suspected of coronary heart disease

Medicine ◽

10.1097/md.0000000000004817 ◽

2016 ◽

Vol 95 (36) ◽

pp. e4817 ◽

Cited By ~ 3

Author(s):

Kuibao Li ◽

Xiyan Yang ◽

Lefeng Wang ◽

Mulei Chen ◽

Wenshu Zhao ◽

...

Keyword(s):

Vitamin D ◽

Coronary Heart Disease ◽

Heart Disease ◽

Coronary Stenosis ◽

Smoking Status

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Systemic immune-inflammation index predicts the severity of coronary stenosis in patients with coronary heart disease

Coronary Artery Disease ◽

10.1097/mca.0000000000001037 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Yehong Liu ◽

Ting Ye ◽

Liang Chen ◽

Tianhui Jin ◽

Ying Sheng ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Coronary Stenosis ◽

Immune Inflammation

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AK098656: a new biomarker of coronary stenosis severity in hypertensive and coronary heart disease patients

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-022-00783-3 ◽

2022 ◽

Vol 14 (1) ◽

Author(s):

Xin Wang ◽

Ya-li Wu ◽

Yuan-yuan Zhang ◽

Jing Ke ◽

Zong-wei Wang ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Roc Curve ◽

Coronary Stenosis ◽

Area Under The Curve ◽

Discrimination Ability ◽

Chd Risk ◽

Significant Difference ◽

Stenosis Severity ◽

Novel Target

Abstract Background AK098656 may be an adverse factor for coronary heart disease (CHD), especially in patients with hypertension. This study aimed to analyze the effect of AK098656 on CHD and CHD with various complications. Methods A total of 117 CHD patients and 27 healthy control subjects were enrolled in the study. Plasma AK098656 expression was determined using the quantitative real-time polymerase chain reaction. Student’s t-test was used to compare AK098656 expression levels in different groups. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to quantify the discrimination ability between CHD patients and health controls and between CHD and CHD + complications patients. The relationship between AK098656 and coronary stenosis was analyzed using Spearman’s correlation. Results AK098656 expression was remarkably higher in CHD patients than in healthy controls (P = 0.03). The ROC curve revealed an effective predictive AK098656 expression value for CHD risk, with an AUC of 0.656 (95% CI 0.501–0.809). Moreover, AK098656 expression was increased in CHD + complications patients compared to CHD patients alone (P = 0.005), especially in patients with hypertension (CHD + hHTN, P = 0.030). The ROC curve revealed a predictive AK098656 prognostic value for discriminating between CHD and CHD + hHTN patients, with an AUC of 0.666 (95% CI 0.528–0.805). There was no significant difference in AK098656 expression in CHD patients with diabetes mellitus compared to CHD patients alone. In addition, AK098656 expression in CHD patients was positively correlated with stenosis severity (R = 0.261, P = 0.006). Conclusion AK098656 expression was significantly increased in patients with CHD, especially those with hypertension, and its expression level was positively correlated with the degree of coronary stenosis. This implied that AK098656 may be a risk factor for CHD and can potentially be applied in clinical diagnosis or provide a novel target for treatment.

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AK098656 – A New Biomarker of Coronary Stenosis Severity in Hypertensive and Coronary Heart Disease Patients

10.21203/rs.3.rs-934224/v1 ◽

2021 ◽

Author(s):

Xin Wang ◽

Ya-li Wu ◽

Yuan-yuan Zhang ◽

Jing Ke ◽

Bao-yu Zhang ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Roc Curve ◽

Coronary Stenosis ◽

Area Under The Curve ◽

Discrimination Ability ◽

Chd Risk ◽

Significant Difference ◽

Stenosis Severity ◽

Novel Target

Abstract Background: AK098656 may be an adverse factor for coronary heart disease (CHD), especially in patients with hypertension. This study aimed to analyze the effect of AK098656 on CHD and CHD with various complications.Methods: A total of 117 CHD patients and 27 healthy control subjects were enrolled in the study. Plasma AK098656 expression was determined using the quantitative real-time polymerase chain reaction. Student’s t-test was used to compare AK098656 expression levels in different groups. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to quantify the discrimination ability between CHD patients and health controls and between CHD and CHD+complications patients. The relationship between AK098656 and coronary stenosis was analyzed using Spearman’s correlation.Results: AK098656 expression was remarkably higher in CHD patients than in healthy controls (P=0.03). The ROC curve revealed an effective predictive AK098656 expression value for CHD risk, with an AUC of 0.656 (95% CI: 0.501–0.809). Moreover, AK098656 expression was increased in CHD+complications patients compared to CHD patients alone (P=0.005), especially in patients with hypertension (CHD+hHTN, P=0.030). The ROC curve revealed a predictive AK098656 prognostic value for discriminating between CHD and CHD+hHTN patients, with an AUC of 0.666 (95% CI: 0.528–0.805). There was no significant difference in AK098656 expression in CHD patients with diabetes mellitus compared to CHD patients alone. In addition, AK098656 expression in CHD patients was positively correlated with stenosis severity (R=0.261, P=0.006).Conclusion: AK098656 expression was significantly increased in patients with CHD, especially those with hypertension, and its expression level was positively correlated with the degree of coronary stenosis. This implied that AK098656 may be a risk factor for CHD and can potentially be applied in clinical diagnosis or provide a novel target for treatment.

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Effect of AK098656 on association of hypertension with coronary stenosis severity in coronary heart disease patients

10.21203/rs.3.rs-85416/v1 ◽

2020 ◽

Author(s):

Xin Wang ◽

Ya-li Wu ◽

Yuan-yuan Zhang ◽

Jing Ke ◽

Bao-yu Zhang ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Roc Curve ◽

Coronary Stenosis ◽

Area Under The Curve ◽

Discrimination Ability ◽

Chd Risk ◽

Significant Difference ◽

Stenosis Severity ◽

Novel Target

Abstract Background: AK098656 may be an adverse factor for coronary heart disease (CHD), especially in patients with hypertension. This study aimed to analyze the effect of AK098656 on CHD and CHD with various complications.Methods: A total of 117 CHD patients and 27 healthy control subjects were enrolled in the study. Plasma AK098656 expression was determined using the quantitative real-time polymerase chain reaction. Student’s t-test was used to compare AK098656 expression levels in different groups. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to quantify the discrimination ability between CHD patients and health controls and between CHD and CHD+complications patients. The relationship between AK098656 and coronary stenosis was analyzed using Spearman’s correlation.Results: AK098656 expression was remarkably higher in CHD patients than in healthy controls (P=0.03). The ROC curve revealed an effective predictive AK098656 expression value for CHD risk, with an AUC of 0.656 (95% CI: 0.501–0.809). Moreover, AK098656 expression was increased in CHD+complications patients compared to CHD patients alone (P=0.005), especially in patients with hypertension (CHD+HHTN, P=0.030). The ROC curve revealed a predictive AK098656 prognostic value for discriminating between CHD and CHD+HHTN patients, with an AUC of 0.666 (95% CI: 0.528–0.805). There was no significant difference in AK098656 expression in CHD patients with diabetes mellitus compared to CHD patients alone. In addition, AK098656 expression in CHD patients was positively correlated with stenosis severity (R=0.261, P=0.006).Conclusion: AK098656 expression was significantly increased in patients with CHD, especially those with hypertension, and its expression level was positively correlated with the degree of coronary stenosis. This implied that AK098656 may be a risk factor for CHD and can potentially be applied in clinical diagnosis or provide a novel target for treatment.

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