scholarly journals Triamcinolone acetonide combined with aminoguanidine inhibits inflammation and oxidative stress, improves vascular endothelial and retinal function and reduces VEGF expression in diabetic retinopathy patients

2020 ◽  
Author(s):  
Kai Xu ◽  
Hanliang Qian ◽  
Meibo Zou
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Triamcinolone Acetonide ◽  
Retinal Function ◽  
Vascular Endothelial ◽  
Vegf Expression ◽  
And Oxidative Stress

MicroRNA-199a Protects Diabetic Retinopathy Under Streptozotocin Conditions by Vascular Endothelial Growth Factor (VEGF)

2020 ◽  
Vol 10 (3) ◽  
pp. 408-412
Author(s):  
Xuemei Wu ◽  
Liang Hui
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Cell Damage ◽  
Vascular Endothelial ◽  
Rt Pcr ◽  
Vegf Expression ◽  
Inflammatory Stress ◽  
Over Expression ◽  
Vegf Signaling ◽  
Endothelial Growth Factor

Inflammatory stress and angiogenesis participate in diabetic retinopathy. miR-199α could inhibit the elevation of wound angiogenesis by suppressing TNF-α and NF-κB pathway. The mechanism of miR-199a in streptozotocin (STZ)-induced cell damage was assessed by ELLISA kit, western blotting, real-time RT-PCR. Reactive oxygen Species (ROS) was measured by flow cytometry. The over expression of miR-199a decreased the STZ-stimulated oxidative stress, inflammatory response, as well as VEGF expression. In conclusion, our results validated that overexpression of miR-199a protects RMECs from STZ-induced inflammation, oxidative stress and angiogenesis by targeting, at least partly, the VEGF signaling.

Hypertension During Vascular Endothelial Growth Factor Inhibition: Focus on Nitric Oxide, Endothelin-1, and Oxidative Stress

2014 ◽  
Vol 20 (1) ◽  
pp. 135-145 ◽  
Author(s):  
Stephanie Lankhorst ◽  
Mariëtte H.W. Kappers ◽  
Joep H.M. van Esch ◽  
A.H. Jan Danser ◽  
Anton H. van den Meiracker
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Endothelin 1 ◽  
Endothelial Growth Factor ◽  
And Oxidative Stress

scholarly journals Rice‐derived peptide AAGALPS inhibits TNF‐α‐induced inflammation and oxidative stress in vascular endothelial cells

2019 ◽  
Vol 8 (1) ◽  
pp. 659-667 ◽  
Author(s):  
Li‐Tao Tong ◽  
Zhiyuan Ju ◽  
Liya Liu ◽  
Lili Wang ◽  
Xianrong Zhou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Tnf Α ◽  
And Oxidative Stress
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