Axl receptor tyrosine kinase is a novel target of apigenin for the inhibition of cell proliferation

Novel Target

P2.01-086 Luteolin is a Novel Target of Axl Receptor Tyrosine Kinase to Inhibit Cell Proliferation and Circumvent Chemoresistance in Lung Cancer Cells

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2016.11.1138 ◽

2017 ◽

Vol 12 (1) ◽

pp. S840

Author(s):

Kyungchan Kim

Keyword(s):

Lung Cancer ◽

Cell Proliferation ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Lung Cancer Cells ◽

Novel Target ◽

Inhibit Cell Proliferation

The Akt–mTORC1 pathway mediates Axl receptor tyrosine kinase‐induced mesangial cell proliferation

Journal of Leukocyte Biology ◽

10.1002/jlb.2a1220-850rrr ◽

2021 ◽

Author(s):

Yuxuan Zhen ◽

Tracy L. McGaha ◽

Fred D. Finkelman ◽

Wen‐Hai Shao

Keyword(s):

Cell Proliferation ◽

Tyrosine Kinase ◽

Mesangial Cell ◽

Mesangial Cell Proliferation ◽

Mtorc1 Pathway

Curcumin-induced downregulation of Axl receptor tyrosine kinase inhibits cell proliferation and circumvents chemoresistance in non-small lung cancer cells

International Journal of Oncology ◽

10.3892/ijo.2015.3216 ◽

2015 ◽

Vol 47 (6) ◽

pp. 2296-2303 ◽

Cited By ~ 13

Author(s):

KYUNG-CHAN KIM ◽

SUK-HWAN BAEK ◽

CHUHEE LEE

Keyword(s):

Lung Cancer ◽

Cell Proliferation ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Lung Cancer Cells ◽

AXL receptor tyrosine kinase (AXL; UFO)

Science-Business eXchange ◽

10.1038/scibx.2012.725 ◽

2012 ◽

Vol 5 (28) ◽

pp. 725-725

Keyword(s):

Tyrosine Kinase ◽

564 Co-expression of Axl-receptor tyrosine kinase and its ligand GAS6 in non-small cell lung cancer cell lines

Lung Cancer ◽

10.1016/s0169-5002(97)89944-8 ◽

1997 ◽

Vol 18 ◽

pp. 145

Author(s):

A. Wimmel ◽

D. Glitz ◽

K. Havemann ◽

M. Schuermann

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Small Cell Lung Cancer ◽

Cell Lines ◽

Cancer Cell ◽

Small Cell ◽

Lung Cancer Cell ◽

Small Cell Lung ◽

Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation

Cell Communication and Signaling ◽

10.1186/s12964-019-0377-8 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 4

Author(s):

Markus Lauter ◽

Anja Weber ◽

Robert Torka

Keyword(s):

Cell Surface ◽

Tyrosine Kinase ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Molecular Mechanism of 17-Allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL Receptor Tyrosine Kinase Degradation

Journal of Biological Chemistry ◽

10.1074/jbc.m112.439422 ◽

2013 ◽

Vol 288 (24) ◽

pp. 17481-17494 ◽

Cited By ~ 32

Author(s):

Gnana Prakasam Krishnamoorthy ◽

Teresa Guida ◽

Luigi Alfano ◽

Elvira Avilla ◽

Massimo Santoro ◽

...

Keyword(s):

Tyrosine Kinase ◽

Molecular Mechanism ◽

The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance

Biomarkers of the Tumor Microenvironment ◽

10.1007/978-3-319-39147-2_15 ◽

2017 ◽

pp. 351-376 ◽

Cited By ~ 1

Author(s):

Kjersti T. Davidsen ◽

Gry S. Haaland ◽

Maria K. Lie ◽

James B. Lorens ◽

Agnete S. T. Engelsen

Keyword(s):

Tyrosine Kinase ◽

Tumor Cell ◽

Therapy Resistance ◽

Cell Plasticity ◽

Tumor Cell Plasticity ◽

Abstract 4711: Novel mechanism involved in the regulation ofoncogenic Axl receptor tyrosine kinase in cancer

10.1158/1538-7445.am2020-4711 ◽

2020 ◽

Author(s):

Hua Wang ◽

Xianzhou Song ◽

Hironari Akasaka ◽

Reza Abbasgholizadeh ◽

Ji-Hyun Shin ◽

...

Keyword(s):

Tyrosine Kinase ◽

Abstract 3969: TP-0903, a potent AXL receptor tyrosine kinase inhibitor, enhances the activity of anti-PD-1 therapy in a metastatic preclinical syngeneic model of breast cancer

10.1158/1538-7445.sabcs18-3969 ◽

2019 ◽

Author(s):

Yuka Kumagai ◽

Jun Oishi ◽

Megumi Nakamura ◽

Jason M. Foulks ◽

Clifford J. Whatcott ◽

...

Keyword(s):

Breast Cancer ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Kinase Inhibitor ◽

Receptor Tyrosine Kinase Inhibitor ◽

Syngeneic Model