scholarly journals Potential role of the cAMP/PKA/CREB signalling pathway in hypoxic preconditioning and effect on propofol‑induced neurotoxicity in the hippocampus of neonatal rats

2019 ◽  
Author(s):  
Ruicong Guan ◽  
Jing Lv ◽  
Fei Xiao ◽  
Youbing Tu ◽  
Yubo Xie ◽  
...  
Keyword(s):  
Potential Role ◽  
Hypoxic Preconditioning ◽  
Signalling Pathway ◽  
Neonatal Rats

scholarly journals Potential role of endoplasmic reticulum stress is involved in the protection of fish oil on neonatal rats with necrotizing enterocolitis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiaoli Zhu ◽  
Ningxun Cui ◽  
Lingling Yu ◽  
Ping Cheng ◽  
Mingling Cui ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Fish Oil ◽  
Necrotizing Enterocolitis ◽  
Potential Role ◽  
Neonatal Rats

scholarly journals Exploring the potential role of sonic hedgehog cell signalling pathway in antidepressant effects of nicotine in chronic unpredictable mild stress rat model

Heliyon ◽  
2019 ◽  
Vol 5 (5) ◽  
pp. e01600 ◽  
Author(s):  
Mohd Tayyab ◽  
Mehdi H. Shahi ◽  
Shirin Farheen ◽  
Mubeena Mariyath P.M. ◽  
Nabeela Khanam ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Rat Model ◽  
Potential Role ◽  
Cell Signalling ◽  
Signalling Pathway ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Antidepressant Effects ◽  
Cell Signalling Pathway

scholarly journals Calpain-TRPC6 Signaling Pathway Contributes to Propofol-Induced Developmental Neurotoxicity in Rats

2021 ◽  
Author(s):  
Ying-Jun She ◽  
Hai-Ping Xu ◽  
Yin Gao ◽  
Qiong Wang ◽  
Jun Zheng ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Signaling Pathway ◽  
Behavioral Disorders ◽  
Potential Role ◽  
Prolonged Exposure ◽  
Neuronal Injury ◽  
Developmental Neurotoxicity ◽  
Calpain Inhibitor ◽  
Neonatal Rats

Abstract Background Compelling experimental evidence suggests a risk of neuronal damage following early childhood exposure to anesthesia and sedation drugs, including propofol. We investigated whether the transient receptor potential canonical 6 (TRPC6) channel could protect neonatal rats against developmental neurotoxicity following prolonged exposure to propofol. The potential role of calpain, a neuronal TRPC6 protease, was also investigated. Methods Postnatal day 7 rats were exposed to five bolus injections of 25 mg/kg propofol or 10% intralipid at hourly intervals. Acute neuronal injury was assessed by the expression pattern of terminal deoxynucleotidyl transferase nick-end labeling staining and cleaved–caspase-3 in the prefrontal cortex. The Morris water maze test was used to evaluate learning and memory functions in later life. Pretreatments consisting of intracerebroventricular injections of a TRPC6 agonist, TRPC6 inhibitor, or calpain inhibitor were used to confirm the potential role of a calpain–TRPC6 pathway. Results Prolonged exposure to propofol induced acute neuronal injury, downregulation of TRPC6, and enhancement of calpain activity in the prefrontal cortex up to 24 h after anesthesia. It also induced later behavioral disorders, manifesting as longer escape latency and as fewer platform-crossing times and less time spent in the target quadrant during postnatal days 35–42. These propofol-induced effects were attenuated by TRPC6 agonist and calpain inhibitor while exaggerated by TRPC6 inhibitor. Treatment with calpain inhibitor also attenuated the propofol-induced TRPC6 downregulation in the prefrontal cortex. Conclusions A calpain–TRPC6 signaling pathway contributes to propofol-induced acute neuronal injury and long-term behavioral disorders in neonatal rats.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

1255: Potential Role of Postoperative Azotemia in Predicting Response to Interleukin-2 (IL-2) Immunotherapy Following Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 414-414
Author(s):  
John S. Lam ◽  
Rakhee H. Gael ◽  
Tobias Klatte ◽  
Fairooz F. Kabbinavar ◽  
Arie S. Belldegrun ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Potential Role ◽  
Interleukin 2 ◽  
Cytoreductive Nephrectomy

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

The Potential Role of the Cytochrome P-450 2D6 Pharmacogenetic Polymorphism in Drug Abuse

1997 ◽  
Author(s):  
Edward M. Sellers ◽  
S. Victoria Otton ◽  
Rachel F. Tyndale
Keyword(s):  
Drug Abuse ◽  
Potential Role ◽  
Cytochrome P 450

Potential Role of Sex-Steroid Depletion in Dementia: Implications for Treatment

2009 ◽  
Author(s):  
Channing Harris
Keyword(s):  
Potential Role ◽  
Sex Steroid
Sign in / Sign up

Export Citation Format

Share Document