Rho regulates the hepatocyte growth factor/scatter factor-stimulated cell motility of human oral squamous cell carcinoma cells

2003 ◽  
Author(s):  
Hiroyuki Kitajo ◽  
Toshiyuki Shibata ◽  
Hiroki Nagayasu ◽  
Takashi Kawano ◽  
Jun-Ichi Hamada ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Hepatocyte Growth Factor ◽  
Cell Motility ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Scatter Factor ◽  
Hepatocyte Growth

Hepatocyte Growth Factor/Scatter Factor Stimulates Mitogenesis and Migration of a Head and Neck Squamous Cell Carcinoma Cell Line

2002 ◽  
Vol 127 (4) ◽  
pp. 271-278 ◽  
Author(s):  
Jeffery Fleigel ◽  
Jack Sedwick ◽  
Lori J. Kornberg
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Cell Line ◽  
Squamous Cell ◽  
Cultured Cells ◽  
Scatter Factor ◽  
Hepatocyte Growth

OBJECTIVE: We sought to assess the effect of extracellular matrix and hepatocyte growth factor/scatter factor (HGF/SF) on the growth and motility of cultured squamous cell carcinoma of the head and neck (SCCHN) cells. METHODS: Cultured cells were incubated in the presence of HGF/SF. The effect of HFG/SF on cell growth, motility, and phosphorylation of the signaling proteins FAK and Erk was determined. RESULTS: HGF/SF is both mitogenic and motogenic to the human SCCHN cell line FaDu. Incubation of FaDu cells in the presence of HGF/SF led to a rapid increase in phosphorylation of both FAK and the growth-promoting kinase Erk. HGF/SF-induced phosphorylation of FAK and Erk was observed in both detached and attached SCCHN cells. However, phosphorylation was much greater in attached cells. CONCLUSIONS AND SIGNIFICANCE: The mitogenic and motogenic activities of HGF/SF may contribute to the pathogenesis of SCCHN in vivo.

Sign in / Sign up

Export Citation Format

Share Document