The evaluation of gastric cancer sensitivity to 5-FU/CDDP in terms of induction of apoptosis: Time- and p53 expression-dependency of anti-cancer drugs

2005 ◽  
Author(s):  
Nobuhisa Matsuhashi ◽  
Masanao Saio ◽  
Atsushi Matsuo ◽  
Yasuyuki Sugiyama ◽  
Shigetoyo Saji
Keyword(s):  
Gastric Cancer ◽  
Cancer Drugs ◽  
P53 Expression ◽  
Anti Cancer ◽  
Induction Of Apoptosis

Mapping Binding Sites of Potential Anti-Cancer Drugs on Tubulin

2000 ◽  
Vol 6 (S2) ◽  
pp. 236-237
Author(s):  
Huilin Li ◽  
Eva Nogales ◽  
Kenneth H. Downing
Keyword(s):  
Cell Cycle ◽  
Side Effects ◽  
Binding Sites ◽  
Microtubule Dynamics ◽  
Cancer Drugs ◽  
Substantial Fraction ◽  
Dynamic Activity ◽  
Anti Cancer ◽  
Main Protein ◽  
Induction Of Apoptosis

Microtubules are involved in many activities within the cell that require highly dynamic activity. For examples, microtubules can grow and shrink as they explore the cell, and the entire microtubule cytoskeleton is restructured as cells prepare for division. Interfering with microtubule dynamics can have serious consequences for the health of the cell, especially in cells that are rapidly dividing. The result of disrupting the normal dynamics is generally an interruption of the cell cycle and consequent induction of apoptosis. This behavior has been exploited with a number of anti-cancer drugs that target tubulin, the main protein in microtubules. Drugs are currently in use that either stabilize or destabilize microtubules. Among the most widely used is Taxol, one of the microtubule stabilizing drugs. Because Taxol produces a range of serious side effects and a substantial fraction of patients treated with Taxol eventually develop resistance to the drug, there is an active search for other drugs that might be more selective and less prone to resistance.

Study on Biomaterials of Anti-Gastric Trametenolic Acid B Semi-Synthetic Derivatives

2014 ◽  
Vol 918 ◽  
pp. 32-35
Author(s):  
Xi Ming Yan ◽  
Ming Ruo Ding ◽  
Ming Guo Liu ◽  
Jun Zhi Wang ◽  
Nian Yu Huang
Keyword(s):  
Gastric Cancer ◽  
Hot Spots ◽  
Medicinal Chemistry ◽  
Cancer Drugs ◽  
Physiological Conditions ◽  
Anti Cancer ◽  
Bioactive Ingredients ◽  
Ph Decrease ◽  
Synthetic Derivatives

Discovery of bioactive ingredients from plants and fungi is always the hot spots in medicinal chemistry. The trametenolic acid B was a bioactive lanostane-type triterpenoid inTrametes lactinea(Berk.) Pat. In this work, four semi-synthetic derivatives were synthesized, characterized and evaluated the anti-gastric cancer activities against HGC-27 cells with the aim of obtaining better anti-tumor agents. The compounds2aand3bpossessed good anti-proliferative effects under normal physiological conditions, and their anti-cancer effects increased as the pH decrease to 5.5 with the IC50of 17.55 and 10.63 μM, respectively. These compounds might be further developed as anti-gastric cancer drugs.

scholarly journals Identification of Candidate Genes Determining Chemosensitivity to Anti-cancer Drugs of Gastric Cancer Cell Lines

2009 ◽  
Vol 32 (11) ◽  
pp. 1936-1939 ◽  
Author(s):  
Tomoki Nakamura ◽  
Noriyuki Nakatsu ◽  
Yoko Yoshida ◽  
Kanami Yamazaki ◽  
Shingo Dan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Candidate Genes ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Lines ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Gastric Cancer Cell Lines

Prognostic effects of oral anti-cancer drugs as adjuvant chemotherapy for 2 years after gastric cancer surgery

Surgery Today ◽  
2012 ◽  
Vol 42 (8) ◽  
pp. 734-740 ◽  
Author(s):  
Toshiro Okuyama ◽  
Daisuke Korenaga ◽  
Ai Edagawa ◽  
Shinji Itoh ◽  
Eiji Oki ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Chemotherapy ◽  
Cancer Surgery ◽  
Cancer Drugs ◽  
Gastric Cancer Surgery ◽  
Anti Cancer

scholarly journals Cancer/Testis Antigen CAGE Exerts Negative Regulation on p53 Expression through HDAC2 and Confers Resistance to Anti-cancer Drugs

2010 ◽  
Vol 285 (34) ◽  
pp. 25957-25968 ◽  
Author(s):  
Youngmi Kim ◽  
Hyunmi Park ◽  
Deokbum Park ◽  
Yun-Sil Lee ◽  
Jongseon Choe ◽  
...  
Keyword(s):  
Negative Regulation ◽  
Cancer Testis Antigen ◽  
Cancer Drugs ◽  
P53 Expression ◽  
Anti Cancer ◽  
Cancer Testis

Induction of apoptosis and inhibition of telomerase activity in human bone marrow and HL-60 p53 null cells treated with anti-cancer drugs

2005 ◽  
Vol 19 (4) ◽  
pp. 523-532 ◽  
Author(s):  
I. Malerba ◽  
L. Gribaldo ◽  
C. Diodovich ◽  
M. Carloni ◽  
R. Meschini ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Telomerase Activity ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Induction Of Apoptosis
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