scholarly journals Possible Implication of Long Term Sucrose Diet on Integumentary Tissues’ Minerals of Male Albino Rats

2019 ◽  
Vol 15 (1) ◽  
pp. 7-13
Author(s):  
B.A. Salau ◽  
T.B. Salau ◽  
A.K. Atunnise ◽  
K.T. Odufuwa ◽  
O.J. Avwioroko ◽  
...  
Keyword(s):  
Albino Rats ◽  
Sucrose Diet

scholarly journals A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats

2016 ◽  
Vol 57 (1) ◽  
pp. 339-349 ◽  
Author(s):  
Eunice Molinar-Toribio ◽  
Elisabet Fuguet ◽  
Sara Ramos-Romero ◽  
Núria Taltavull ◽  
Lucía Méndez ◽  
...  
Keyword(s):  
High Fat ◽  
Metabolic Fate ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

scholarly journals Tramadol Induced Adrenal Insufficiency: Histological, Immunohistochemical, Ultrastructural, and Biochemical Genetic Experimental Study

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Shereen Abdelhakim Abdelaleem ◽  
Osama A. Hassan ◽  
Rasha F. Ahmed ◽  
Nagwa M. Zenhom ◽  
Rehab A. Rifaai ◽  
...  
Keyword(s):  
Adrenal Insufficiency ◽  
Thioredoxin Reductase ◽  
Serum Cortisol ◽  
Treated Group ◽  
Control Group ◽  
Albino Rats ◽  
Narcotic Drug ◽  
Biochemical Genetic ◽  
Withdrawal Effects

Tramadol is a synthetic, centrally acting analgesic. It is the most consumed narcotic drug that is prescribed in the world. Tramadol abuse has dramatically increased in Egypt. Long term use of tramadol can induce endocrinopathy. So, the aim of this study was to analyze the adrenal insufficiency induced by long term use of tramadol in experimental animals and also to assess its withdrawal effects through histopathological and biochemical genetic study. Forty male albino rats were used in this study. The rats were divided into 4 groups (control group, tramadol-treated group, and withdrawal groups). Tramadol was given to albino rats at a dose of 80 mg/kg body weight for 3 months and after withdrawal periods (7–15 days) rats were sacrificed. Long term use of tramadol induced severe histopathological changes in adrenal glands. Tramadol decreased the levels of serum cortisol and DHEAS hormones. In addition, it increased the level of adrenal MDA and decreased the genetic expression of glutathione peroxidase and thioredoxin reductase in adrenal gland tissues. All these changes started to return to normal after withdrawal of tramadol. Thus, it was confirmed that long term use of tramadol can induce severe adrenal insufficiency.

A long-term high-fat, high-sucrose diet in Bama minipigs promotes lipid deposition and amyotrophy by up-regulating the myostatin pathway

2016 ◽  
Vol 425 ◽  
pp. 123-132 ◽  
Author(s):  
Jinxue Ruan ◽  
Yuanyuan Zhang ◽  
Jing Yuan ◽  
Leilei Xin ◽  
Jihan Xia ◽  
...  
Keyword(s):  
Lipid Deposition ◽  
High Fat ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

scholarly journals Long-term oral administration of osteocalcin induces insulin resistance in male mice fed a high-fat, high-sucrose diet

2016 ◽  
Vol 310 (8) ◽  
pp. E662-E675 ◽  
Author(s):  
Yu Yasutake ◽  
Akiko Mizokami ◽  
Tomoyo Kawakubo-Yasukochi ◽  
Sakura Chishaki ◽  
Ichiro Takahashi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Oral Administration ◽  
Pancreatic Β Cell ◽  
Male Mice ◽  
High Fat ◽  
Β Cell ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

Uncarboxylated osteocalcin (GluOC), a bone-derived hormone, regulates energy metabolism by stimulating insulin secretion, pancreatic β-cell proliferation, and adiponectin expression in adipocytes. Previously, we showed that long-term intermittent or daily oral administration of GluOC reduced the fasting blood glucose level, improved glucose tolerance, and increased the fasting serum insulin concentration as well as pancreatic β-cell area in female mice fed a normal or high-fat, high-sucrose diet. We have now performed similar experiments with male mice and found that such GluOC administration induced glucose intolerance, insulin resistance, and adipocyte hypertrophy in those fed a high-fat, high-sucrose diet. In addition, GluOC increased the circulating concentration of testosterone and reduced that of adiponectin in such mice. These phenotypes were not observed in male mice fed a high-fat, high-sucrose diet after orchidectomy, but they were apparent in orchidectomized male mice or intact female mice that were fed such a diet and subjected to continuous testosterone supplementation. Our results thus reveal a sex difference in the effects of GluOC on glucose homeostasis. Given that oral administration of GluOC has been considered a potentially safe and convenient option for the treatment or prevention of metabolic disorders, this sex difference will need to be taken into account in further investigations.

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