scholarly journals A dose-response study of consuming high-fructose corn syrup–sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults

2015 ◽  
Vol 101 (6) ◽  
pp. 1144-1154 ◽  
Author(s):  
Kimber L Stanhope ◽  
Valentina Medici ◽  
Andrew A Bremer ◽  
Vivien Lee ◽  
Hazel D Lam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Young Adults ◽  
Dose Response ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
Sweetened Beverages ◽  
High Fructose ◽  
Dose Response Study

scholarly journals Consumption of Fructose and High Fructose Corn Syrup Increase Postprandial Triglycerides, LDL-Cholesterol, and Apolipoprotein-B in Young Men and Women

2011 ◽  
Vol 96 (10) ◽  
pp. E1596-E1605 ◽  
Author(s):  
Kimber L. Stanhope ◽  
Andrew A. Bremer ◽  
Valentina Medici ◽  
Katsuyuki Nakajima ◽  
Yasuki Ito ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Apolipoprotein B ◽  
Area Under The Curve ◽  
High Fructose Corn Syrup ◽  
Complex Carbohydrate ◽  
Added Sugar ◽  
Corn Syrup ◽  
Sweetened Beverages ◽  
High Fructose

Abstract Context: The American Heart Association Nutrition Committee recommends women and men consume no more than 100 and 150 kcal of added sugar per day, respectively, whereas the Dietary Guidelines for Americans, 2010, suggests a maximal added sugar intake of 25% or less of total energy. Objective: To address this discrepancy, we compared the effects of consuming glucose, fructose, or high-fructose corn syrup (HFCS) at 25% of energy requirements (E) on risk factors for cardiovascular disease. Participants, Design and Setting, and Intervention: Forty-eight adults (aged 18–40 yr; body mass index 18–35 kg/m2) resided at the Clinical Research Center for 3.5 d of baseline testing while consuming energy-balanced diets containing 55% E complex carbohydrate. For 12 outpatient days, they consumed usual ad libitum diets along with three servings per day of glucose, fructose, or HFCS-sweetened beverages (n = 16/group), which provided 25% E requirements. Subjects then consumed energy-balanced diets containing 25% E sugar-sweetened beverages/30% E complex carbohydrate during 3.5 d of inpatient intervention testing. Main Outcome Measures: Twenty-four-hour triglyceride area under the curve, fasting plasma low-density lipoprotein (LDL), and apolipoprotein B (apoB) concentrations were measured. Results: Twenty-four-hour triglyceride area under the curve was increased compared with baseline during consumption of fructose (+4.7 ± 1.2 mmol/liter × 24 h, P = 0.0032) and HFCS (+1.8 ± 1.4 mmol/liter × 24 h, P = 0.035) but not glucose (−1.9 ± 0.9 mmol/liter × 24 h, P = 0.14). Fasting LDL and apoB concentrations were increased during consumption of fructose (LDL: +0.29 ± 0.082 mmol/liter, P = 0.0023; apoB: +0.093 ± 0.022 g/liter, P = 0.0005) and HFCS (LDL: +0.42 ± 0.11 mmol/liter, P < 0.0001; apoB: +0.12 ± 0.031 g/liter, P < 0.0001) but not glucose (LDL: +0.012 ± 0.071 mmol/liter, P = 0.86; apoB: +0.0097 ± 0.019 g/liter, P = 0.90). Conclusions: Consumption of HFCS-sweetened beverages for 2 wk at 25% E increased risk factors for cardiovascular disease comparably with fructose and more than glucose in young adults.

5-LB: Consuming High-Fructose Corn Syrup or Sucrose-Sweetened Beverages Increases Hepatic Lipid Content and Decreases Insulin Sensitivity in Young Adults

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 5-LB
Author(s):  
DESIREE SIGALA ◽  
BETTINA HIERONIMUS ◽  
CANDICE PRICE ◽  
VIVIEN LEE ◽  
MARINELLE NUNEZ ◽  
...  
Keyword(s):  
Young Adults ◽  
Insulin Sensitivity ◽  
Lipid Content ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
Hepatic Lipid ◽  
Sweetened Beverages ◽  
High Fructose ◽  
Hepatic Lipid Content

scholarly journals Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII, and ApoE in humans consuming a high-fructose corn syrup-sweetened beverage

2018 ◽  
Vol 315 (2) ◽  
pp. E141-E149 ◽  
Author(s):  
Candice (Allister) Price ◽  
Donovan A. Argueta ◽  
Valentina Medici ◽  
Andrew A. Bremer ◽  
Vivien Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
High Fructose Corn Syrup ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Corn Syrup ◽  
Testing Period ◽  
Sweetened Beverages ◽  
High Fructose

Epidemiological and clinical research studies have provided ample evidence demonstrating that consumption of sugar-sweetened beverages increases risk factors involved in the development of obesity, Type 2 diabetes, and cardiovascular disease (CVD). Our previous study demonstrated that when compared with aspartame (Asp), 2 wk of high-fructose corn syrup (HFCS)-sweetened beverages provided at 25% of daily energy requirement was associated with increased body weight, postprandial (pp) triglycerides (TG), and fasting and pp CVD risk factors in young adults. The fatty acid ethanolamide, anandamide (AEA), and the monoacylglycerol, 2-arachidonoyl- sn-glycerol (2-AG), are two primary endocannabinoids (ECs) that play a role in regulating food intake, increasing adipose storage, and regulating lipid metabolism. Therefore, we measured plasma concentrations of ECs and their analogs, oleoylethanolamide (OEA), docosahexaenoyl ethanolamide (DHEA), and docosahexaenoyl glycerol (DHG), in participants from our previous study who consumed HFCS- or Asp-sweetened beverages to determine associations with weight gain and CVD risk factors. Two-week exposure to either HFCS- or Asp-sweetened beverages resulted in significant differences in the changes in fasting levels of OEA and DHEA between groups after the testing period. Subjects who consumed Asp, but not HFCS, displayed a reduction in AEA, OEA, and DHEA after the testing period. In contrast, there were significant positive relationships between AEA, OEA, and DHEA vs. ppTG, ppApoCIII, and ppApoE in those consuming HFCS, but not in those consuming Asp. Our findings reveal previously unknown associations between circulating ECs and EC-related molecules with markers of lipid metabolism and CVD risk after HFCS consumption.

scholarly journals Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals

2008 ◽  
Vol 87 (5) ◽  
pp. 1194-1203 ◽  
Author(s):  
Kimber L Stanhope ◽  
Steven C Griffen ◽  
Brandi R Bair ◽  
Michael M Swarbrick ◽  
Nancy L Keim ◽  
...  
Keyword(s):  
Metabolic Profiles ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
Sweetened Beverages ◽  
High Fructose

scholarly journals High fructose corn syrup‐sweetened cola and the hypothalamus: a dose‐response fMRI study

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Samantha Hudgins ◽  
Alexei Smaliy ◽  
Wang Zhan ◽  
Jayme L Leger ◽  
Sarah Gebauer ◽  
...  
Keyword(s):  
Dose Response ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
Fmri Study ◽  
High Fructose

Perceived Healthiness of Sweeteners among Young Adults in Canada

2020 ◽  
pp. 1-5
Author(s):  
Samantha Goodman ◽  
Lana Vanderlee ◽  
Amanda Jones ◽  
Christine White ◽  
David Hammond
Keyword(s):  
Young Adults ◽  
Online Survey ◽  
Consumer Preferences ◽  
Energy Content ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
Low Calorie ◽  
High Fructose ◽  
Raw Sugar ◽  
Youth And Young Adults

Purpose: To compare the perceived healthiness of different sweeteners relative to table sugar and examine efforts to consume less sugars and sweeteners. Methods: As part of the 2017 Canada Food Study online survey, 1000 youth and young adults were randomized to rate the healthiness of 1 of 6 sweeteners (aspartame, sucralose, stevia, agave, high-fructose corn syrup, “raw” sugar) or 1 sweetener brand name (Splenda) compared with “table sugar”. Results: Perceptions of sweeteners varied widely. For example, the majority of respondents perceived high-fructose corn syrup (63.9%) and aspartame (52.4%) as less healthy than table sugar, whereas almost half (47.8%) perceived raw sugar as being healthier than table sugar. No assessed socio-demographic variables were significantly associated with perceived healthiness of sweeteners compared with table sugar (P ≥ 0.05). More consumers had attempted to consume less sugar (65.4%) compared with less “artificial” (31.2%) or “natural” (24.0%) low-calorie sweeteners. Conclusions: Perceptions of sweetener healthiness may be related to sweeteners’ perceived level of “naturalness” rather than energy content. This has important implications for understanding consumer preferences, particularly given greater use of low-calorie sweeteners in the food supply and policy developments such as sugar taxes and enhanced sugar labelling.

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