scholarly journals Comparing the effects of sucrose and high-fructose corn syrup on lipid metabolism and the risk of cardiovascular disease in male rats

2017 ◽  
Vol 16 (2) ◽  
pp. 231-240
Author(s):  
Joanna Sadowska ◽  
◽  
Magda Bruszkowska
Keyword(s):  
Cardiovascular Disease ◽  
Lipid Metabolism ◽  
Male Rats ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
High Fructose

scholarly journals Assessing the effect of sugar type and form of its intake on selected parameters of carbohydrate-lipid metabolism and plasma atherogenic indices in rats

2019 ◽  
pp. 59-67
Author(s):  
Joanna Sadowska ◽  
Magda Bruszkowska
Keyword(s):  
Lipid Metabolism ◽  
Water Solution ◽  
Blood Parameters ◽  
Male Rats ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
Carbohydrate And Lipid Metabolism ◽  
Group I ◽  
High Fructose ◽  
Weight Gains

ABSTRACT Background. Over the past 50 years, the average consumption of sugar worldwide has tripled, also the type of consumed sugar has changed. Due to high price of sucrose and its technological disadvantages, high fructose corn syrup (HFCS) has become one of the most commonly used substitutes. Objective. The aim of the study was to compare, on the animal model, the effect of sugar type (sucrose vs high fructose corn syrup 55% of fructose) and the sugar form (solid vs fluid and solid) on the chosen parameters of carbohydrate-lipid metabolism. Material and methods. The experiment was carried out on 40 Wistar male rats aged 5 months, fed four isocaloric diets, containing: group I (SUC 15%) fodder with 15% sucrose, group II (HFCS 15%) fodder with 15% HFCS-55%, group III (SUC 7.5%+7.5%) – 7.5% sucrose in solid fodder and 7.5% sucrose water solution, group IV (HFCS 7.5%+7.5%) – 7.5% HFCS-55% in solid fodder and 7.5% HFCS water solution. Results. The effect of HFCS-55 on the parameters of carbohydrate and lipid metabolism was not equivalent of the effect of sucrose. Dietary use of HFCS-55 instead of sucrose causes adverse changes in blood parameters of carbohydrate and lipid metabolism, particularly when provided in beverages, as at comparable weight gains to that of sucrose. More intense changes, manifesting in increased blood levels of glucose, triglycerides and uric acid, as well as increased liver fat content, were observed at simultaneous intake of sweeteners in solid foods and fluids, even with less sugar consumption, compared to solid food only. Conclusions. Dietary use of HFCS-55 causes adverse changes in blood parameters of carbohydrate and lipid metabolism, as at comparable weight gains to that of sucrose. But liquid form of sugar intake is more important insulin resistance and cardiovascular disease risk factor than the sugar type.

Melatonin protects the heart and endothelium against high fructose corn syrup consumption–induced cardiovascular toxicity via SIRT-1 signaling

2019 ◽  
Vol 38 (10) ◽  
pp. 1212-1223 ◽  
Author(s):  
M Savran ◽  
H Asci ◽  
O Ozmen ◽  
Y Erzurumlu ◽  
HB Savas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Damage ◽  
Sirtuin 1 ◽  
Male Rats ◽  
Stress Index ◽  
High Fructose Corn Syrup ◽  
Cardiovascular Toxicity ◽  
Corn Syrup ◽  
High Fructose ◽  
Creatine Kinase Mb

High fructose corn syrup (HFCS) has been shown to cause cardiovascular toxicity via oxidative stress and inflammation. The aim of this study is to demonstrate the protective effects of melatonin (MLT) against HFCS-induced endothelial and cardiac dysfunction via oxidative stress and inflammation. Thirty-two Sprague Dawley male rats were distributed into three groups as control, HFCS, and HFCS + MLT. HFCS form F55 was prepared as 20% fructose syrup solution and given to the rats through drinking water for 10 weeks, and MLT administrated 10 mg/kg/day orally for last 6 weeks in addition to F55. After decapitation, blood and half of the heart samples were collected for biochemical analysis and other half of the tissues for histopathological and immunohistochemical analysis. Aspartate transaminase, creatine kinase MB, lactate dehydrogenase, total oxidant status and oxidative stress index, and caspase-3 levels increased and total antioxidant status levels decreased significantly in HFCS group. MLT treatment reversed all these parameters. Histopathologically, hyperemia, endothelial cell damage and increased levels of angiogenin, C-reactive protein, inducible nitric oxide synthase, myeloperoxidase and decreased sirtuin-1 (SIRT-1) expressions were observed in HFCS group. MLT ameliorated all these changes. MLT has an anti-inflammatory, antioxidant, antiapoptotic effects on HFCS-induced cardiovascular toxicity through enhancing the expression of SIRT-1.

scholarly journals Consumption of Fructose and High Fructose Corn Syrup Increase Postprandial Triglycerides, LDL-Cholesterol, and Apolipoprotein-B in Young Men and Women

2011 ◽  
Vol 96 (10) ◽  
pp. E1596-E1605 ◽  
Author(s):  
Kimber L. Stanhope ◽  
Andrew A. Bremer ◽  
Valentina Medici ◽  
Katsuyuki Nakajima ◽  
Yasuki Ito ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Apolipoprotein B ◽  
Area Under The Curve ◽  
High Fructose Corn Syrup ◽  
Complex Carbohydrate ◽  
Added Sugar ◽  
Corn Syrup ◽  
Sweetened Beverages ◽  
High Fructose

Abstract Context: The American Heart Association Nutrition Committee recommends women and men consume no more than 100 and 150 kcal of added sugar per day, respectively, whereas the Dietary Guidelines for Americans, 2010, suggests a maximal added sugar intake of 25% or less of total energy. Objective: To address this discrepancy, we compared the effects of consuming glucose, fructose, or high-fructose corn syrup (HFCS) at 25% of energy requirements (E) on risk factors for cardiovascular disease. Participants, Design and Setting, and Intervention: Forty-eight adults (aged 18–40 yr; body mass index 18–35 kg/m2) resided at the Clinical Research Center for 3.5 d of baseline testing while consuming energy-balanced diets containing 55% E complex carbohydrate. For 12 outpatient days, they consumed usual ad libitum diets along with three servings per day of glucose, fructose, or HFCS-sweetened beverages (n = 16/group), which provided 25% E requirements. Subjects then consumed energy-balanced diets containing 25% E sugar-sweetened beverages/30% E complex carbohydrate during 3.5 d of inpatient intervention testing. Main Outcome Measures: Twenty-four-hour triglyceride area under the curve, fasting plasma low-density lipoprotein (LDL), and apolipoprotein B (apoB) concentrations were measured. Results: Twenty-four-hour triglyceride area under the curve was increased compared with baseline during consumption of fructose (+4.7 ± 1.2 mmol/liter × 24 h, P = 0.0032) and HFCS (+1.8 ± 1.4 mmol/liter × 24 h, P = 0.035) but not glucose (−1.9 ± 0.9 mmol/liter × 24 h, P = 0.14). Fasting LDL and apoB concentrations were increased during consumption of fructose (LDL: +0.29 ± 0.082 mmol/liter, P = 0.0023; apoB: +0.093 ± 0.022 g/liter, P = 0.0005) and HFCS (LDL: +0.42 ± 0.11 mmol/liter, P < 0.0001; apoB: +0.12 ± 0.031 g/liter, P < 0.0001) but not glucose (LDL: +0.012 ± 0.071 mmol/liter, P = 0.86; apoB: +0.0097 ± 0.019 g/liter, P = 0.90). Conclusions: Consumption of HFCS-sweetened beverages for 2 wk at 25% E increased risk factors for cardiovascular disease comparably with fructose and more than glucose in young adults.

scholarly journals Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII, and ApoE in humans consuming a high-fructose corn syrup-sweetened beverage

2018 ◽  
Vol 315 (2) ◽  
pp. E141-E149 ◽  
Author(s):  
Candice (Allister) Price ◽  
Donovan A. Argueta ◽  
Valentina Medici ◽  
Andrew A. Bremer ◽  
Vivien Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
High Fructose Corn Syrup ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Corn Syrup ◽  
Testing Period ◽  
Sweetened Beverages ◽  
High Fructose

Epidemiological and clinical research studies have provided ample evidence demonstrating that consumption of sugar-sweetened beverages increases risk factors involved in the development of obesity, Type 2 diabetes, and cardiovascular disease (CVD). Our previous study demonstrated that when compared with aspartame (Asp), 2 wk of high-fructose corn syrup (HFCS)-sweetened beverages provided at 25% of daily energy requirement was associated with increased body weight, postprandial (pp) triglycerides (TG), and fasting and pp CVD risk factors in young adults. The fatty acid ethanolamide, anandamide (AEA), and the monoacylglycerol, 2-arachidonoyl- sn-glycerol (2-AG), are two primary endocannabinoids (ECs) that play a role in regulating food intake, increasing adipose storage, and regulating lipid metabolism. Therefore, we measured plasma concentrations of ECs and their analogs, oleoylethanolamide (OEA), docosahexaenoyl ethanolamide (DHEA), and docosahexaenoyl glycerol (DHG), in participants from our previous study who consumed HFCS- or Asp-sweetened beverages to determine associations with weight gain and CVD risk factors. Two-week exposure to either HFCS- or Asp-sweetened beverages resulted in significant differences in the changes in fasting levels of OEA and DHEA between groups after the testing period. Subjects who consumed Asp, but not HFCS, displayed a reduction in AEA, OEA, and DHEA after the testing period. In contrast, there were significant positive relationships between AEA, OEA, and DHEA vs. ppTG, ppApoCIII, and ppApoE in those consuming HFCS, but not in those consuming Asp. Our findings reveal previously unknown associations between circulating ECs and EC-related molecules with markers of lipid metabolism and CVD risk after HFCS consumption.

Fructose and high fructose corn syrup: are they a two-edged sword?

2021 ◽  
pp. 1-23
Author(s):  
Nasim Khorshidian ◽  
Mahdi Shadnoush ◽  
Maryam Zabihzadeh Khajavi ◽  
Sara Sohrabvandi ◽  
Mojtaba Yousefi ◽  
...  
Keyword(s):  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
High Fructose
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