scholarly journals Lipid-Based Nutrient Supplements Do Not Affect the Risk of Malaria or Respiratory Morbidity in 6- to 18-Month-Old Malawian Children in a Randomized Controlled Trial

2014 ◽  
Vol 144 (11) ◽  
pp. 1835-1842 ◽  
Author(s):  
Charles Mangani ◽  
Per Ashorn ◽  
Kenneth Maleta ◽  
John Phuka ◽  
Chrissie Thakwalakwa ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Respiratory Morbidity ◽  
Randomized Controlled ◽  
Nutrient Supplements

scholarly journals Lipid-based Nutrient Supplements Prenatal sebagai Tindakan Preventif Terjadinya Berat Badan Lahir Rendah dan Penurunan Fungsi Kognitif pada Bayi

2021 ◽  
Vol 8 (3) ◽  
pp. 128-136
Author(s):  
Muhammad Thifan Satyagraha ◽  
Rafi Annisa Ulum ◽  
Farhan Syafiq Fadhilah
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trial ◽  
Arachidonic Acid ◽  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Literature Review ◽  
Controlled Trial ◽  
Specific Fatty Acid ◽  
Randomized Controlled ◽  
Nutrient Supplements

Pendahuluan: Stunting di Indonesia masih tergolong tinggi. Salah satu faktor risikonya adalah kejadian berat badan lahir rendah pada bayi. Jika tidak diatasi, kualitas sumber daya manusia di  Indonesia menjadi rendah. Maka, pemberian Lipid-based Nutrient Supplements (LNS), yang telah dilakukan oleh beberapa negara tetangga dalam rangka mengoptimalkan berat badan lahir rendah dan daya kognitif bayi, perlu dilakukan penelitian. Penelitian ini bertujuan untuk mengumpulkan dan menganalisis artikel yang berhubungan dengan pengaruh pemberian LNS pada ibu hamil terhadap berat badan lahir dan daya kognitif pada bayi. Metode: Desain yang digunakan adalah literature review, artikel dikumpulkan dengan menggunakan mesin pencari Google melalui beberapa sumber data seperti Pubmed, Science Direct, Proquest, Kemenkes, dan BPS RI. Kriteria artikel yang digunakan adalah jurnal penelitian dengan metode Randomized Controlled Trial dan Systematic Review yang diterbitkan pada tahun 2015 – 2020. Pembahasan: Berdasarkan artikel yang dikumpulkan, hasilnya menunjukan bahwa LNS yang diberikan pada ibu hamil dapat meningkatkan massa tubuh dan meningkatkan volume otak pada bayi. Hal ini disebabkan oleh Brain Specific Fatty Acid yang meliputi docosahexaenoic acid (DHA) and arachidonic acid (ARA) yang menunjang pembentukan jaringan, imunitas, dan perkembangan saraf. Simpulan: Pemberian LNS pada di daerah yang prevalensi stunting masih tinggi dapat menjadi solusi atas permasalahan stunting di daerah tersebut. Saran dari penelitian ini adalah untuk dibuat suatu program LNS, khususnya di daerah yang prevalensi stunting masih tinggi.

A randomized controlled trial of restricted versus standard fluid management in late preterm and term infants with transient tachypnea of the newborn

2020 ◽  
Vol 13 (4) ◽  
pp. 477-487
Author(s):  
S. Sardar ◽  
S. Pal ◽  
R. Mishra
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Initial Period ◽  
Fluid Management ◽  
Late Preterm ◽  
Respiratory Morbidity ◽  
Term Infants ◽  
Randomized Controlled ◽  
Antenatal Steroid ◽  
Preterm Babies

BACKGROUND: Transient tachypnea of the newborn(TTNB) is the most common respiratory morbidity in late preterm and term babies and is pathophysiologically related to delayed lung fluid clearance after birth. Mimicking low physiological fluid intake in the initial period of life may accelerate the recovery from TTNB. In a randomized controlled trial, we compared the roles of restricted versus standard fluid management in babies with TTNB requiring respiratory support. METHODS: This parallel group,non-blinded, stratified randomized controlled trial was conducted in a level III neonatal unit of eastern India. Late preterm and term babies with TTNB requiring continuous positive airway pressure (CPAP) were randomly allocated to standard and restricted fluid arms for the first 72 hours (hrs). Primary outcome was CPAP duration. RESULTS: In total, 100 babies were enrolled in this study with 50 babies in each arm. CPAP duration was significantly less in the restricted arm (48[42, 54] hrs vs 54[48,72] hrs, p = 0.002). However, no difference was observed in the incidence of CPAP failure between the two arms. In the subgroup analysis, the benefit of reduced CPAP duration persisted in late preterm but not in term infants. However, the effect was not significant in the late preterm babies exposed to antenatal steroid. CONCLUSION: This trial demonstrated the safety and effectiveness of restrictive fluid strategy in reducing CPAP duration in late preterm and term babies with TTNB. Late preterm babies, especially those not exposed to antenatal steroid were the most benefitted by this strategy.

scholarly journals Evaluating the Efficacy of Seattle-PAP for the Respiratory Support of Premature Neonates: Study Protocol for a Randomized Controlled Trial

2018 ◽  
Author(s):  
Carl H. Backes ◽  
Apurwa Naik ◽  
Thomas N. Hansen ◽  
Larissa I. Stanberry ◽  
John A. F. Zupancic ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
The United States ◽  
Respiratory Support ◽  
Respiratory Morbidity ◽  
Large Trial ◽  
Premature Neonates ◽  
Randomized Controlled ◽  
Respiratory Management

Abstract Background: At birth, the majority of neonates born at <30 weeks of gestation require respiratory support to facilitate transition and ensure adequate gas exchange. Although the optimal approach to the initial respiratory management is uncertain, the American Academy of Pediatrics endorses noninvasive respiratory support with nasal continuous positive airway pressure (nCPAP) for premature neonates with respiratory insufficiency. Despite evidence for its use, nCPAP failure, requiring intubation and mechanical ventilation is common. Recently, investigators have described a novel method to deliver bubble nCPAP, termed Seattle-PAP. While preclinical and pilot studies are encouraging with regard to the potential value of Seattle-PAP, a large trial is needed to compare Seattle-PAP directly with the current standard of care for bubble nCPAP (Fisher Paykel-CPAP; FP-CPAP). Methods: We designed a multicenter, non-blinded, randomized controlled trial that will enroll 230 premature infants (220/7 to 296/7 weeks of gestation). Infants will be randomized to receive Seattle-PAP or FP-CPAP. The primary outcome is respiratory failure requiring intubation and mechanical ventilation. Secondary outcomes include measures of short and long-term respiratory morbidity and cost effectiveness. Discussion: This trial will assess whether Seattle-PAP is more efficacious and cost effective than FP-CPAP in real-world practice among premature neonates. Trial Registration: This trial has been registered with the United States National Library of Medicine (www.clinicaltrials.gov, Trial Identifier #NCT03085329). Registered on 21 March 2017.

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