Effective Case Selection Based on Static and Dynamic Reservoir Uncertainty

Author(s):  
T.G. Grossmann
2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 244-244
Author(s):  
Sheeno P. Thyparambil ◽  
Jin You ◽  
Kang Liu ◽  
Hui Sun ◽  
Junjie Peng ◽  
...  

244 Background: Implementation of population screening for colorectal cancer (CRC) before colonoscopy can reduce the challenge of the overall capacity of bowel examination and improve survival. Blood based CRC assessment biomarkers, on a triage concept, can lead to improved selection to colonoscopy and cost-effective CRC care. Methods: Innovative multi-omics approaches, with global and targeted LCMS data production (metabolomics, lipidomics, and 2D proteomics) and integrative data analytics, were applied to discover serological biomarkers to assess nonadvanced adenoma and identify stage I/II colorectal bowel lesions. A cohort of 2396 normal, 660 adenoma, 953 stage I, and 101 stage II blood samples, was constructed to discover screening biomarkers to support case finding of patients at high risk for nonadvanced adenoma and stage I/II cancer for subsequent diagnostic colonoscopy. Results: A three-analyte mProbe panel was constructed which outperformed the commercial assays of plasma methylated septin 9 and fecal Cologuard tests. Sensitivity: (1) nonadvanced adenoma–Cologuard 17.2%, mProbe 76.0%; (2) stage I-III-Cologuard 93.3%, stage I-II Septin 9 (ARUP laboratories) 77%, stage I-II mProbe: 92.3%. Specificity–Cologuard 89.8%, Septin 9 (ARUP laboratories) 88%, mProbe 90.7%. Conclusions: mProbe triage concept of a blood-based protein biomarker panel promises the precision to allow future CRC screening, and reduce the low-risk utilization of unnecessary, unpleasant and risk-associated bowel examinations.


2010 ◽  
Vol 6 (2) ◽  
pp. 71 ◽  
Author(s):  
Lindsay A Smith ◽  
Amit Bhan ◽  
Mark J Monaghan ◽  
◽  
◽  
...  

Echocardiography provides excellent realtime imaging of the heart, making it the imaging modality of choice immediately before, during and after cardiac interventional procedures. It helps to guide case selection and execution of the intervention, evaluates the effects of the intervention and enables early detection of complications. Advances in the design and technology of medical devices and delivery systems, coupled with demand for alternative non-surgical therapies for common medical problems, have led to an increase in the volume, variety and complexity of non-coronary cardiac interventional procedures performed. Many of these procedures require a multidisciplinary team approach and demand optimal imaging to ensure successful outcomes. The aim of this article is to review the expanding role of echocardiography in non-coronary interventional cardiology in adults.


2020 ◽  
pp. 99-106

Many optometrists supplement office-based vision therapy with home-based vision therapy procedures. Others prescribe primarily home-based vision therapy activities with in-office instruction. With recent development of telehealth online platforms, it is possible to enhance home-based vision therapy with one-on-one doctor-guided and vision therapist-guided remote optometric vision therapy (ROVT). This may increase access for times when the patient is not able to present to the office. Procedures for implementing ROVT are discussed including patient selection, case management, and technical requirements. 35 patients received ROVT, with the vast majority responding positively. Three cases of ROVT are presented. While there are significant limitations to ROVT, this experience shows that it is possible to conduct ROVT when there is need. We found that case selection and parental support at home are important factors for success.


Author(s):  
Paul Chaisty ◽  
Nic Cheeseman ◽  
Timothy J. Power

This chapter introduces the three regions—sub-Saharan Africa, Latin America, and the Former Soviet Union—and the nine countries—Armenia, Benin, Brazil, Chile, Ecuador, Kenya, Malawi, Russia, and Ukraine—that provide the empirical material for the book. It introduces the two criteria used for case selection: 1) democratic competitiveness; 2) de jure and de facto constitutional provisions that empower presidents to be coalitional formateurs. It also introduces a variable that measures the salience of cross-party cooperation: the Index of Coalitional Necessity. Finally, it sketches the political landscape that has shaped the dynamics of coalitional presidentialism within each region, and it draws attention to important contextual differences between the nine country cases.


Author(s):  
Mor Hodaya Or ◽  
Izhak Berkovich

Despite the popularity of distributed leadership theory, the investigation of the micro-political aspects of such models have scarcely been explored, and insights on the cultural variety of distributed practices in schools are limited. The present study aimed to explore what micro-political aspects emerge in participative decision making in collectivist and individualist cultures. To this end, a multiple case study method was adopted, focusing on four Israeli public high schools. Schools were chosen to represent an ‘extreme’ case selection rationale: two non-religious urban schools representing individualist cases, and two communal schools in religious kibbutzim representing communal schools. The analysis shed light on three micro-political points of comparison between the prototypes of participative decision making in collectivist and individualist cultures related to control, actors, and stage crafting. The findings and implications are discussed.


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