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2021 ◽  
Vol 16 (22) ◽  
pp. 113-128
Sergii Sharov ◽  
Oksana Filatova ◽  
Valentyna Biliatska ◽  
Nadia Yankova

The article provides a quantitative analysis of the online courses which can be used for student training in the humanities. It is noted that the development of in-formation society influenced the ways of educational activities organization, the process of obtaining new knowledge and competency formation. Under the con-ditions when online education, blended and distance learning are considerably relevant, massive open online courses are an effective tool for learning and self-development. It was found that training in the humanities plays an important role in personal development of the future specialist. It involves the development of social competence, communication culture, leadership skills, as well as skills of conflict avoidance, teamwork, etc. The effectiveness of training in the humanities is influenced by active teaching methods, interactive technologies, and various means of information and communication technologies. The authors analyzed both the English-language (Coursera, Udemy, Edx) and Ukrainian-language (Prometheus, EdEra, OUM) online platforms. The article provides a quantitative analysis of online courses according to various directions in the humanities on each of the platforms. As of October 2021, we identified 4,769 free and fee-paying courses. The largest number of online courses for training in the humani-ties is presented on the Udemy platform (4,295 courses), the smallest number – on all Ukrainian-language platforms together (45 courses).

2021 ◽  
Vol 2021 ◽  
pp. 1-20
Xiang-Ming Wang ◽  
Shang-Wei Chen ◽  
Gang Chen ◽  
Hua-Fu Zhou ◽  
Ting-Qing Gan ◽  

This study is aimed at thoroughly exploring the expression status, clinical significance, and underlying molecular mechanism of miRNA-33a-5p in lung squamous cell carcinoma (LUSC). Here, we detected miRNA-33a-5p in 20 samples from patients with LUSCs and 20 matching non-LUSC specimens by in-house quantitative real-time PCR (RT-qPCR). Relationship between miRNA-33a-5p expression and clinicopathological traits was investigated from materials derived from miRNA sequencing and miRNA microarrays. A pool standard mean difference (SMD) and summary receiver operating characteristic curves (SROC) were calculated to evaluate the integrated expression value of miRNA-33a-5p in LUSC. Twelve online platforms were applied to select potential target genes of miRNA-33a-5p. The differentially expressed genes (DEGs) of LUSC and the candidate target genes of miRNA-33a-5p were overlapped to acquire a set of specific genes for further analyses of the Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), and protein–protein interaction (PPI) network. miRNA-33a-5p overexpressed in LUSC was supported by 706 LUSC and 261 non-LUSC samples gathering from RT-qPCR, miRNA-seq, and public miRNA microarrays. The pooled SMD was 0.56 (95% CI: -0.01-1.05), and the area under the curve (AUC) of the SROC was 0.78 (95% CI: 0.74-0.82). A total of 240 genes were identified as potential target genes of miRNA-33a-5p for functional enrichment analyses; the results suggested that these target genes may participate in several vital biological processes that promote the proliferation and progression of LUSC. miRNA-33a-5p may play an essential role in the occurrence and development of LUSC by targeting hub genes (ETS1, EDNRB, CYR61, and LRRK2) derived from the PPI network. In summary, our results indicated that miRNA-33a-5p may contribute as a prospective therapeutic target in LUSC.

2021 ◽  
Vol 3 (3) ◽  
pp. 11-21
Monique Cloete ◽  
Jessica Michele Ellington ◽  
Anke Jansen van Vuuren ◽  
Elisca Adele Marais ◽  
Poppy Masinga

Due to the COVID-19 pandemic, there was an accelerated migration from face-to-face to online learning. This article aims to explore and describe how psychology students experienced the migration from face-to-face to online learning during the COVID-19 pandemic. It entailed a qualitative research design with an exploratory and descriptive approach. The participants were 28 purposively sampled psychology students from a Private Higher Education Institution in Gauteng. An online survey method was employed to gather the needed information which was then subjected to a thematic analysis. It emerged that the challenges experienced by students were internet connectivity issues, insufficient computer literacy, reduced class time, anxiety, physical impact, and communication issues. Moreover, some benefits related to flexibility, the convenience of online studies and safety from infection with COVID-19 were identified. It was also noted that having certain attributes such as independence, time management skills, having support and being tech savvy improved the online learning process. Some opportunities for Higher Education Institutions to improve the experiences of students included creativity in module delivery as well as providing guidelines on how to use these online platforms.

Nathanstee Q. Anayan ◽  
Virgil L. Penuela

The new era of technologies around the globe continues transforming the process of innovation particularly in the province of Romblon where the community is being active and updated about the trends of technology, however, due to the limited bandwidth signal of internet connection, their telecommunications are affected especially during this new normal where the Business Transactions, Learning Management System, and other Essential Services are done through online. The purpose of this study is to propose an IT business project especially a technology hub that will cater to and satisfy the needs of the community on the Island. The impact of this study is simply for connecting and moving people into the fastest and easiest way of communication using social media and other online platforms. The proposed Technology hub is composed of four areas, the Internet Café, Printing Press, Research Learning Area, and Photo Studio. This is very beneficial to the people in the community especially to the students that needs IT services. This study aims to help the people, the Local Government Unit, and the University to make their goals put into reality. This study will truly change and innovate the lives of the people even for the progress of the economy, culture, and lifestyle of the place. This study is also recommended for the implementation of Techno hub within the island since this could give an opportunity to give new jobs, especially for the IT professions. This is very responsive to the needs of the society in terms of socialization, communication, and education.

2021 ◽  
Rebecca Raeside ◽  
Si Si Jia ◽  
Julie Redfern ◽  
Stephanie R Partridge

BACKGROUND Adolescence is a critical life stage characterised by an interplay of biological, social and environmental factors. Such factors influence lifestyle health related trajectories, including dietary behaviours, physical activity levels, body weight and sleep hygiene. Generation Z (born 1995-2015) are the most internet-dependent and technologically savvy generation in history with increasing rates of smartphone ownership in both developed and developing nations. Gaps exist in our understanding of what online platforms adolescents are using and the barriers and facilitators of these platforms to seek lifestyle health information. OBJECTIVE We evaluated adolescents’ perceptions on the use of contemporary digital platforms (websites, social media platforms and smartphone apps) to seek information or advice related to lifestyle heath. METHODS Virtual focus groups were held via Zoom teleconference between July to August 2021. Eligible participants were 13-18 years, living in Australia and had searched for online lifestyle health information in the previous three months. For this study, lifestyle health information referred to key behaviours and risk factors for chronic disease, namely, diet, physical activity, weight management and sleep. Participants were recruited through an existing database of research participants and networks of the research team. Focus groups were analysed using the Framework approach, where data is systematically searched to recognize patterns in the data and manage, analyse and identify themes. Focus group audio files were transcribed verbatim and independently coded by two researchers (RR, SJ). Through an iterative and reflexive process, a final coding matrix was agreed on by all researchers and used to thematically analyse the data. RESULTS Five focus groups were held (n=32, mean age 16.3(1.4), 18/32, 56% female, 13/32, 41% spoke language other than English at home). Thematic analysis revealed participants searched for information both actively (e.g., on Google or YouTube) and passively (e.g., scrolling social media and using existing apps preloaded to their smartphone such as Apple ‘Health’, Samsung ‘Health’ or ‘Google Fit’ apps). Participants identified that the most helpful information was well-organised in terms of aesthetic appeal and layout, came from a credible and reliable source (e.g. any sponsorships disclosed) and expressed the need for the information to be relatable. Mixed views were reported for the application of lifestyle health information found online. Some participants reported behaviour change, while others noted that certain advice was hard to maintain and incorporate into their lifestyle. CONCLUSIONS This study highlights the abundance and complexity of lifestyle health information online for adolescents. Adolescents in the digital age seek access to information that is appealing, credible, relevant and actionable for lifestyle health behaviours. To appeal to the needs of adolescents, future interventions for adolescents relating to lifestyle health must consider co-design methodological approaches. Furthermore, the regulation of lifestyle health information available online warrants further investigation.

2021 ◽  
Vol 12 ◽  
Zhe Zhang ◽  
Zilong Tan ◽  
Qiaoli Lv ◽  
Lichong Wang ◽  
Kai Yu ◽  

Background: Glioma is the most common primary tumor of the central nervous system and is associated with poor overall survival, creating an urgent need to identify survival-associated biomarkers. C1ORF112, an alpha-helical protein, is overexpressed in some cancers; however, its prognostic role has not yet been explored in gliomas. Thus, in this study, we attempted to address this by determining the prognostic value and potential function of C1ORF112 in low-grade gliomas (LGGs).Methods: The expression of C1ORF112 in normal and tumor tissues was analyzed using data from The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), Oncomine, and Rembrandt databases. The genetic changes of C1ORF112 in LGG were analyzed using cBioPortal. Survival analysis was used to evaluate the relationship between C1ORF112 expression and survival in patients with LGG. Correlation between immune infiltration and C1ORF112 expression was determined using Timer software. Additionally, data from three online platforms were integrated to identify the co-expressed genes of C1ORF112. The potential biological functions of C1ORF112 were investigated by enrichment analysis.Results: C1ORF112 mRNA was highly expressed in LGGs (p < 0.01). Area under the ROC curve (AUC) showed that the expression of C1ORF112 in LGG was 0.673 (95% confidence interval [CI] = 0.618–0.728). Kaplan-Meier survival analysis showed that patients with high C1ORF112 expression had lower OS than patients with low C1ORF112 expression (p < 0.05). Multivariate analysis showed that high expression of C1ORF112 was an independent prognostic factor for the overall survival in patients from TCGA and CGGA databases. C1ORF112 expression was positively correlated with six immunoinfiltrating cells (all p < 0.001). The enrichment analysis suggested the enrichment of C1ORF112 and co-expressed genes in cell cycle and DNA replication.Conclusion: This study suggested that C1ORF112 may be a prognostic biomarker and a potential immunotherapeutic target for LGG.

2021 ◽  
Vol 1 (1) ◽  
pp. 1-34
Li Tian

Consider that 26.3 million people live in Shanghai and 20 million live in Beijing as of 2019. Now consider that these 46.3 million people live within an area of approximately 23,000 km². By comparison, Canada’s population in 2019 was 37.6 million and the area of Canada is approximately 10 million km². China is on the leading edge of smart-city projects because population density gives it little choice. China must take bold steps in terms of both technology and regulation to cope with the demands for social management, which these megacities create. Accordingly, about half of the Smart City Projects globally are in China.  Many smart cities pilot projects are underway across China addressing many infrastructures and other organizational concerns. One such organizational concern is coping with the solid waste generated in cities. China produces more than 300 million tons of solid waste per year, and much of it comes from its cities.   This research project explores China's food and beverage delivery online platforms and the waste they cause. In 2019, this industry has developed rapidly, generating economic activity valued at ¥ 653.6 billion that year ($CAD 121 billion). Out of a total population of 1.4 billion, 460 million people are currently consumers of these online platforms. Most of these consumers live in China’s megacities. This consumption is not projected to decrease post-pandemic. The problem is that solid waste from this industry in 2019 weighed approximately 2.7 million tons.   This paper analyzes reasons why the online food take-out industry has caused a plastic waste surge from the perspective of China's environmental legislation, law enforcement efficiency, and recycling subsidies. At the same time, through the case study of the German Packaging Law, this paper suggested on the management and recycling of Chinese take-out packaging were put forward.   The Chinese government has issued national standards for the design and construction of smart cities. This paper explores how to use legal governance and supervision in smart city design and operation to assist in implementing environmental regulations to control the take-out waste. The take-out waste problem does not only exist in China. Almost all major cities in the world are facing this problem. China's experiences may provide a new path for the city's solid waste disposal and other environmental issues and lead the cities to explore more environmental protection possibilities.


The education field has undergone a new norm due to the pandemic of COVID-19 and it can be seen that new techniques and improvements can be applied among the educators and students. In a Malaysian context, it is revealed that a majority of universities have enhanced the quality of teaching via online platforms such as Cisco Webex, Google Meet, Zoom and many more that provide the medium for instructional delivery. However, it is also imperative to view the situation from the students’ perspectives in order to identify the issues that have occurred throughout the online learning process. The current study is conducted to identify the level of adaptability among students towards online learning and it consists of several components such as physical, spiritual, and emotional aspects. The respondents were selected through purposive sampling from selected local universities in Malaysia where about 316 students participated. This study was done quantitatively, and the results were analysed using Smart PLS 3.2.8. The findings showed that there were high values of Cronbach alpha and composite reliability which indicates that students agreed with the items in all the constructs in terms of physical (α=0.879, CR=0.906), spiritual (α =0.863, CR=0.901), emotional (α=0.953, CR=0.961) and adaptability (α=0.913, CR=0.931). The validity (AVE) of all the constructs were also in the acceptable range. It reveals that the physical, spiritual, and emotional components are imperative in order to ensure students could adapt with the new norm of online learning during the pandemic of COVID-19. Other than that, it shows that a balance well-being could hinder problems related to tough learning situation especially in online learning. Keywords: Online learning; Malaysian student, Well-being, Pandemic, Adaptability

2021 ◽  
Vol 15 (1) ◽  
Alex Odlum ◽  
Rosemary James ◽  
Audrey Mahieu ◽  
Karl Blanchet ◽  
Chiara Altare ◽  

Abstract Background For humanitarian organisations to respond effectively to complex crises, they require access to up-to-date evidence-based guidance. The COVID-19 crisis has highlighted the importance of updating global guidance to context-specific and evolving needs in humanitarian settings. Our study aimed to understand the use of evidence-based guidance in humanitarian responses during COVID-19. Primary data collected during the rapidly evolving pandemic sheds new light on evidence-use processes in humanitarian response. Methods We collected and analysed COVID-19 guidance documents, and conducted semi-structured interviews remotely with a variety of humanitarian organisations responding and adapting to the COVID-19 pandemic. We used the COVID-19 Humanitarian platform, a website established by three universities in March 2020, to solicit, collate and document these experiences and knowledge. Results We analysed 131 guidance documents and conducted 80 interviews with humanitarian organisations, generating 61 published field experiences. Although COVID-19 guidance was quickly developed and disseminated in the initial phases of the crisis (from January to May 2020), updates or ongoing revision of the guidance has been limited. Interviews conducted between April and September 2020 showed that humanitarian organisations have responded to COVID-19 in innovative and context-specific ways, but have often had to adapt existing guidance to inform their operations in complex humanitarian settings. Conclusions Experiences from the field indicate that humanitarian organisations consulted guidance to respond and adapt to COVID-19, but whether referring to available guidance indicates evidence use depends on its accessibility, coherence, contextual relevance and trustworthiness. Feedback loops through online platforms like the COVID-19 Humanitarian platform that relay details of these evidence-use processes to global guidance setters could improve future humanitarian response.

2021 ◽  
Can Küçükgül ◽  
Özalp Özer ◽  
Shouqiang Wang

Many online platforms offer time-locked sales campaigns, whereby products are sold at fixed prices for prespecified lengths of time. Platforms often display some information about previous customers’ purchase decisions during campaigns. Using a dynamic Bayesian persuasion framework, we study how a revenue-maximizing platform should optimize its information policy for such a setting. We reformulate the platform’s problem equivalently by reducing the dimensionality of its message space and proprietary history. Specifically, three messages suffice: a neutral recommendation that induces a customer to make her purchase decision according to her private signal about the product and a positive (respectively (resp.), negative) recommendation that induces her to purchase (resp., not purchase) by ignoring her signal. The platform’s proprietary history can be represented by the net purchase position, a single-dimensional summary statistic that computes the cumulative difference between purchases and nonpurchases made by customers having received the neutral recommendation. Subsequently, we establish structural properties of the optimal policy and uncover the platform’s fundamental trade-off: long-term information (and revenue) generation versus short-term revenue extraction. Further, we propose and optimize over a class of heuristic policies. The optimal heuristic policy provides only neutral recommendations up to a cutoff customer and provides only positive or negative recommendations afterward, with the recommendation being positive if and only if the net purchase position after the cutoff customer exceeds a threshold. This policy is easy to implement and numerically shown to perform well. Finally, we demonstrate the generality of our methodology and the robustness of our findings by relaxing some informational assumptions. This paper was accepted by Gabriel Weintraub, revenue management and market analytics.

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