Wintering is one of the most complicated biotechnical processes in pisciculture, and its success depends on a wide spectrum of biotic and abiotic factors, first of all on the fish physiological status before this period. Sturgeon fishes are believed to stop feeding under the water temperature below 4 °C that causes essential reorganization of their metabolism because of transition to endogenous feeding. Physiological status of fingerlings of kaluga and reciprocal hybrid sterlet x kaluga is compared in the beginning, middle and end of wintering, with comparative characteristic of their peripheral blood reaction and understanding of starvation influence on their digestive and hemopoietic systems. The fingerlings of both species were kept in cages of warm-water farm and fed with fodder. The fingerlings of kaluga started the wintering with improper physiological status, with evident pathological processes expressed as eosinophilia, macrocytic hyperchromic anaemia, increase of immature erythrocytes, and pathomorphological changes of erythrocytes (poikilocytosis, anisocytosis, karyorhexis, hemolysis). These symptoms could be caused by either herpesvirus infection or cumulative polytoxicosis, but results of hematological and histological analysis in the middle and end of the wintering confirmed the viral nature. Thus, mass disease and mortality of fish is possible in conditions of the temperature increase in spring. Therefore, prophylactic measures are recommended for overwintered kaluga fingerlings to enhance their immune and physiological status, such as addition of vitamins C and E, probiotics and prebiotics to fodder. On the contrary, the fingerlings of reciprocal hybrid sterlet x kaluga had a high physiological status before and during wintering, in spite of a rather high portion of eosinophiles in their leukogram.