scholarly journals Effects of Combination of G-CSF and SCF One Week Prior to Liver Injury In Acute liver Damage Model Induced by Thioacetamide Administration

2014 ◽  
Vol 2 (1) ◽  
pp. 21-25
Author(s):  
Ali Asghar Yoonesi ◽  
Durdi Qujeq ◽  
Mohsen Esmaili ◽  
Farideh Feizi ◽  
◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Damage ◽  
Damage Model ◽  
Acute Liver Damage

scholarly journals BML-257, a small molecule that protects against drug induced liver injury in zebrafish

2022 ◽  
Author(s):  
Urmila Jagtap ◽  
Sandeep Basu ◽  
Lavanya Lokhande ◽  
Nikhil Bharti ◽  
Chetana Sachidanandan
Keyword(s):  
Liver Injury ◽  
Small Molecule ◽  
Liver Damage ◽  
Protective Action ◽  
Damage Model ◽  
Akt Inhibitor ◽  
Drug Induced ◽  
Specific Expression ◽  
Drug Induced Liver Injury ◽  
Chemical Screen

The use of many essential drugs is restricted due to their deleterious effects on the liver. Molecules that can prevent or protect the liver from drug induced liver injury (DILI) would be valuable in such situations. We used hepatocyte-specific expression of bacterial nitroreductase in zebrafish to cause temporally controlled liver damage. This transgenic line was used to run a whole organism based chemical screen in zebrafish larvae. In this screen we identified BML-257, a potent small molecule AKT inhibitor, that protected the liver against metronidazole-induced liver injury. BML-257 also showed potent prophylactic and pro-regenerative activity in this liver damage model. BML-257 also showed remarkable protective action in two independent toxicological models of liver injury caused by acetaminophen and Isoniazid. This suggests that BML-257 may have the potential to protect against multiple kinds of drug induced liver injury.

scholarly journals Suppressive effects of mead acid supplementation on acute liver damage model in rats

2020 ◽  
Vol 29 (2) ◽  
pp. 114
Author(s):  
Akiko Takenouchi ◽  
Yuichi Kinoshita ◽  
Yukari Hirayama ◽  
Yumiko Shinke ◽  
Kei Hamazaki ◽  
...  
Keyword(s):  
Liver Damage ◽  
Damage Model ◽  
Acute Liver Damage ◽  
Mead Acid ◽  
Acid Supplementation

scholarly journals Acute liver injury following acetaminophen administration does not activate atrophic pathways in the mouse diaphragm

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
C. S. Bruells ◽  
P. Duschner ◽  
G. Marx ◽  
G. Gayan-Ramirez ◽  
N. Frank ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Liver Injury ◽  
Liver Damage ◽  
Acute Liver Injury ◽  
Serum Levels ◽  
Acute Liver Damage ◽  
Markers Of Inflammation ◽  
Amino Phenol ◽  
And Oxidative Stress

AbstractN-acetyl-para-amino phenol (APAP, usually named paracetamol), which is commonly used for its analgesic and antipyretic properties may lead to hepatotoxicity and acute liver damage in case of overdoses. Released cytokines and oxidative stress following acute liver damage may affect other organs’ function notably the diaphragm, which is particularly sensitive to oxidative stress and circulating cytokines. We addressed this issue in a mouse model of acute liver injury induced by administration of APAP. C57BL/6J mice (each n = 8) were treated with N-acetyl-para-amino phenol (APAP) to induce acute drug caused liver injury and sacrificed 12 or 24 h afterwards. An untreated group served as controls. Key markers of inflammation, proteolysis, autophagy and oxidative stress were measured in diaphragm samples. In APAP treated animals, liver damage was proven by the enhanced serum levels of alanine aminotransferase and aspartate aminotransferase. In the diaphragm, besides a significant increase in IL 6 and lipid peroxidation, no changes were observed in key markers of the proteolytic, and autophagy signaling pathways, other inflammatory markers and fiber dimensions. The first 24 h of acute liver damage did not impair diaphragm atrophic pathways although it slightly enhanced IL-6 and lipid peroxidation. Whether longer exposure might affect the diaphragm needs to be addressed in future experiments.

scholarly journals Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Luciano Rezende Vilela ◽  
Lindisley Ferreira Gomides ◽  
Bruna Araújo David ◽  
Maísa Mota Antunes ◽  
Ariane Barros Diniz ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Damage ◽  
Acute Liver Injury ◽  
Endocannabinoid System ◽  
Protective Role ◽  
Acute Liver Damage ◽  
Protective Actions ◽  
Cocaine Toxicity ◽  
Hepatotoxic Drug

Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Here, we demonstrated that acute cocaine intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate. Considering the protective role of the endocannabinoid system against cell toxicity, we hypothesized that treatment with an anandamide hydrolysis inhibitor, URB597, or with a phytocannabinoid, cannabidiol (CBD), protects against cocaine toxicity. URB597 (1.0 mg/kg) abolished cocaine-induced seizure, yet it did not protect against acute liver injury. Using confocal liver intravital microscopy, we observed that CBD (30 mg/kg) reduced acute liver inflammation and damage induced by cocaine and prevented associated seizure. Additionally, we showed that previous liver damage induced by another hepatotoxic drug (acetaminophen) increased seizure and lethality induced by cocaine intoxication, linking hepatotoxicity to seizure dynamics. These findings suggest that activation of cannabinoid system may have protective actions on both liver and brain induced by cocaine, minimizing inflammatory injury promoted by cocaine, supporting its further clinical application in the treatment of cocaine abuse.

Effect of preliminary fasting on development of acute liver damage by D-galactosamine in rats

1989 ◽  
Vol 107 (1) ◽  
pp. 38-41
Author(s):  
D. Adzharov ◽  
N. Donchev ◽  
M. Kerimova ◽  
E. Naidenova ◽  
B. Borov ◽  
...  
Keyword(s):  
Liver Damage ◽  
Acute Liver Damage

Morin protects acute liver damage by carbon tetrachloride (CCl4) in rat

2008 ◽  
Vol 31 (9) ◽  
pp. 1160-1165 ◽  
Author(s):  
Hee Seung Lee ◽  
Kyung-Hee Jung ◽  
Sang-Won Hong ◽  
In-Suh Park ◽  
Chongmu Lee ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Acute Liver Damage
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