DESIGN OF PORTABLE EPLDALTERA MAX EPM719SQC160-7 AND DSPTMS320V5410PGE APPLICATION FOR NON-INVASIVE IN-EXTRA CRANIAL ARTERIES VASCULAR SYSTEM

2015 ◽  
Vol 27 (03) ◽  
pp. 1550025
Author(s):  
Whi-Young Kim ◽  
Jun-Hyoung Kim
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Death Rate ◽  
Vascular System ◽  
Motor Nerve ◽  
Brain Diseases ◽  
Brain Disorder ◽  
After Effects ◽  
Non Invasive ◽  
Cranial Arteries

The incidence of brain diseases, such as dementia, Parkinson's disease and motor nerve disorder, has increased since 1980s. According to a survey conducted on the incidence in England, US, Japan, Germany and Spain, the dementia death rate, including Alzheimer's disease, had increased by three times for men. The death rate from brain disease, such as Parkinson's disease and motor nerve disorder, has increased by 50% for both men and women. Although this increase can be assumed to be caused by changes in DNA when observing from a genetic perspective, it would take hundreds of years to confirm this. Therefore, environmental factors are regarded as the actual cause. In this situation of a rapidly increasing aging population, the prevention of senile and brain diseases is considered the most important measure because treatment is difficult and the after-effects are severe. A cerebrovascular ultrasonogram, which can frequently allow a self-inspection of the blood vessels for the early detection of the risk factors for disease, is actualized to model with a characteristic test and has shown performance. Supplementation of the system can facilitate an application in the measurement of brain disorder patients with other diseases in the future. This study examined the atypical characteristics through the production of a prototype.

scholarly journals Assessment of the Telomere Length and Its Effect on the Symptomatology of Parkinson’s Disease

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 137
Author(s):  
Tina Levstek ◽  
Sara Redenšek ◽  
Maja Trošt ◽  
Vita Dolžan ◽  
Katarina Trebušak Podkrajšek
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Telomere Length ◽  
Repetitive Sequences ◽  
Housekeeping Gene ◽  
Cellular Aging ◽  
Brain Diseases ◽  
Motor Complications ◽  
Telomere Attrition ◽  
Significant Difference

Telomeres, which are repetitive sequences that cap the end of the chromosomes, shorten with each cell division. Besides cellular aging, there are several other factors that influence telomere length (TL), in particular, oxidative stress and inflammation, which play an important role in the pathogenesis of neurodegenerative brain diseases including Parkinson’s disease (PD). So far, the majority of studies have not demonstrated a significant difference in TL between PD patients and healthy individuals. However, studies investigating the effect of TL on the symptomatology and disease progression of PD are scarce, and thus, warranted. We analyzed TL of peripheral blood cells in a sample of 204 PD patients without concomitant autoimmune diseases and analyzed its association with several PD related phenotypes. Monochrome multiplex quantitative PCR (mmqPCR) was used to determine relative TL given as a ratio of the amount of DNA between the telomere and albumin as the housekeeping gene. We found a significant difference in the relative TL between PD patients with and without dementia, where shorter TL presented higher risk for dementia (p = 0.024). However, the correlation was not significant after adjustment for clinical factors (p = 0.509). We found no correlations between TLs and the dose of dopaminergic therapy when the analysis was adjusted for genetic variability in inflammatory or oxidative factors. In addition, TL influenced time to onset of motor complications after levodopa treatment initiation (p = 0.0134), but the association did not remain significant after adjustment for age at inclusion and disease duration (p = 0.0781). Based on the results of our study we conclude that TL contributes to certain PD-related phenotypes, although it may not have a major role in directing the course of the disease. Nevertheless, this expends currently limited knowledge regarding the association of the telomere attrition and the disease severity or motor complications in Parkinson’s disease.

Beneficial effect of rice bran extract against rotenone-induced experimental Parkinson’s disease in rats

2021 ◽  
Vol 14 ◽  
Author(s):  
Sachin Kumar ◽  
Puneet Kumar
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rice Bran ◽  
Motor Coordination ◽  
Hexane Extract ◽  
Brain Disorder ◽  
Biochemical Alterations ◽  
Transport Chain ◽  
Behavioral Parameters ◽  
Per Oral

Background: Neurodegenerative diseases have become the rising cause of various disabilities worldwide, followed by aging, including Parkinson’s disease (PD). Parkinson’s disease is a degenerative brain disorder distinguished by growing motor & non-motor failure due to the degeneration of medium-sized spiked neurons in the striatum region. Rotenone is often employed to originate the animal model of PD. It is a powerful blocker of mitochondrial complex-I, mitochondrial electron transport chain that reliably produces Parkinsonism-like symptoms in rats. Rice bran (RB) is very rich in polyunsaturated fatty acids (PUFA) and nutritionally beneficial compounds such as γ-oryzanol, tocopherols, and tocotrienols and sterols are believed to have favorable outcomes on oxidative stress & mitochondrial function. Objective: The present study has been designed to explore RB extract’s effect against rotenone-induced neurotoxicity in rats. Method: In the present study, Rotenone (2 mg/kg, s.c) was administered systemically for 28 days. The hexane extract of RB was prepared using Soxhlation. Hexane extract (250 & 500 mg/kg) was administered per oral for 28 days in rotenone treated groups. Behavioral parameters (grip strength, motor coordination, locomotion, and catalepsy) were conducted on the 7th, 14th, 21st, and 28th day. Animals were sacrificed on the 29th day for biochemical estimation in the striatum and cortex. Result: This study demonstrates significant alteration in behavioral parameters, oxidative burden (increased lipid peroxidation, nitrite concentration, and decreased glutathione, catalase, SOD) in rotenone treated animals. Administration of hexane extract of RB prevented the behavioral, biochemical alterations induced by rotenone. The current research has been sketched to inspect RB extract’s effect against rotenone-developed neurotoxicity in rats. Conclusion: The findings support that PD is associated with impairments in motor activity. The results also suggest that the nutraceutical rice bran that contains γ-oryzanol, Vitamin-E, ferulic acid etc., may underlie the adjuvant susceptibility towards rotenone-induced PD in experimental rats.

10-Effects of non-invasive brain stimulation on motor speech disorder in Parkinson’s disease

2018 ◽  
Vol 129 (4) ◽  
pp. e9
Author(s):  
L. Brabenec ◽  
J. Mekyska ◽  
Z. Galáž ◽  
P. Klobušiakova ◽  
M. Koštálová ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Stimulation ◽  
Speech Disorder ◽  
Motor Speech ◽  
Non Invasive ◽  
Motor Speech Disorder

scholarly journals Eye movement evaluation in Multiple Sclerosis and Parkinson’s Disease using a Standardized Oculomotor and Neuro-ophthalmic Disorder Assessment (SONDA)

2020 ◽  
Author(s):  
Alessandro Grillini ◽  
Remco J. Renken ◽  
Anne C. L. Vrijling ◽  
Joost Heutink ◽  
Frans W. Cornelissen
Keyword(s):  
Multiple Sclerosis ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Standardized Tests ◽  
Eye Movement ◽  
Oculomotor System ◽  
Oculomotor Behavior ◽  
Non Invasive ◽  
Spatio Temporal ◽  
Pursuit Gain

AbstractEvaluating the state of the oculomotor system of a patient is one of the fundamental tests done in neuro-ophthalmology. However, up to date, very few quantitative standardized tests of eye movements quality exist, limiting this assessment to confrontational tests reliant on subjective interpretation. Furthermore, quantitative tests relying on eye movement properties such as pursuit gain and saccade dynamics are often insufficient to capture the complexity of the underlying disorders and are often (too) long and tiring. In this study, we present SONDA (Standardised Oculomotor and Neurological Disorder Assessment): this test is based on analyzing eye tracking recorded during a short and intuitive continuous tracking task. We tested patients affected by Multiple Sclerosis (MS) and Parkinson’s Disease (PD) and find that: (1) the saccadic dynamics of the main sequence alone are not sufficient to separate patients from healthy controls; (2) the combination of spatio-temporal and statistical properties of saccades and saccadic dynamics enables an identification of oculomotor abnormalities in both MS and PD patients. We conclude that SONDA constitutes a powerful screening tool that allows an in-depth evaluation of (deviant) oculomotor behavior in a few minutes of non-invasive testing.

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