2181 Retinal Blood Vessels Diameter in a Healthy Cohort as Measured by the Spectral Domain OCT (SD OCT)

Zusammenfassung Hintergrund Zur Erfassung von Metamorphopsien steht im klinischen Alltag der Amsler-Test zur Verfügung. Dieser erfasst qualitativ Metamorphopsien, zur Quantifizierung von Metamorphopsien und als Verlaufskontrolle wurde der computerbasierte Test „AMD – A Metamorphopsia Detector®“ entwickelt. Das Ziel dieser Studie ist zu untersuchen, ob eine Korrelation zwischen zentraler Netzhautdicke (CRT, gemessen mittels Spectral Domain OCT) und quantifizierter Metamorphopsiemessung bei Patienten mit exsudativer altersassoziierter Makuladegeneration (AMD) und diabetischem Makulaödem (DMÖ) besteht. Material und Methoden 66 Augen von 66 Patienten (DMÖ: 19 [11 Männer, 8 Frauen; Alter 42 – 76 Jahre]; AMD: 47 [13 Männer, 34 Frauen; Alter 56 – 93 Jahre]) wurden in dieser explorativen Pilotstudie untersucht und in Hinblick auf das Vorliegen eines Makulaödems (zentrale 500-µm-Zone, Cirrus HD-OCT) klassifiziert. Bestkorrigierter monokularer Fernvisus (BCVA), Amsler-Test, Metamorphopsiemessung (AMD – A Metamorphopsia Detector) mit Angabe des Metamorphopsie-Index (MI), binokulare Ophthalmoskopie, SD-OCT mit Messung der zentralen Netzhautdicke (CRT) und ggf. Fluoreszenzangiografie wurden durchgeführt. Die Korrelation von CRT und MI wurde mittels Spearman-Korrelation geprüft. Ergebnisse BCVA bei DMÖ bzw. AMD betrug (logMAR) 0,27 (SD 0,3) bzw. 0,29 (SD 0,2). Bei Augen mit DMÖ zeigte sich eine Korrelation von MI und CRT mit rho = 0,88 (p < 0,001) und bei Augen mit AMD betrug rho = 0,56 (p < 0,001). Schlussfolgerung Die Korrelation von CRT und MI war bei DMÖ hoch und bei AMD moderat. Künftige Studien sollen untersuchen, ob sich die Metamorphopsiemessung zur Detektion einer Konversion in eine exsudative AMD eignet und ob dies eine Messung zur Verlaufskontrolle, ggf. als Selbsttest ermöglicht.

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Assessment of Posterior Segment Using Spectral Domain OCT in Highly Myopic Eyes

The Open Ophthalmology Journal ◽

10.2174/1874364101711010334 ◽

2017 ◽

Vol 11 (1) ◽

pp. 334-345 ◽

Cited By ~ 1

Author(s):

Heba Radi AttaAllah ◽

Ismail Ahmed Nagib Omar ◽

Ahmed Shawkat Abdelhalim

Keyword(s):

Social Sciences ◽

Posterior Vitreous Detachment ◽

Spectral Domain ◽

Spherical Equivalent ◽

Spearman Correlation ◽

Spectral Domain Oct ◽

Full Thickness Macular Hole ◽

The Social ◽

Sd Oct

Purpose: Spectral Domain Optical Coherence Tomography (SD-OCT) was used to evaluate retinal and vitreo-retinal changes that occur in highly myopic patients. Methods: This prospective study included 472 eyes of 472 patients suffering from high myopia (> -6.00 D), between May 2012 and December 2015. All patients were examined, using Cirrus HD OCT (Zeiss Cirrus TM HD-OCT model 4000), to detect any retinal or vitreo-retinal interface abnormalities. All obtained data was analyzed using Statistical Package for the Social Sciences software version 17 (SPSS Inc, Chicago, IL, USA) and the paired two-sided t-test. Bivariate correlations were performed between different parameters using the Spearman correlation coefficient (r). Results: Mean spherical equivalent (MSE) was -13.11± 4.35D. Mean axial length (AL) was 28.5±1.62 mm. Posterior vitreous detachment (PVD) was the most frequent OCT finding; representing 33.4% of the cases, 13.7% of them were associated with macular traction. A statistically significant positive correlation was found between AL and MTM, full thickness macular hole, PVD with traction, and dome shaped macula (r = 0.49 and P = 0.001, r = 0.422 and P = 0.0001, r = 0.25 and P = 0.03, r=0.475, P=0.001 respectively) Conclusion: OCT is a valuable tool in detecting retinal and vitreo-retinal interface abnormalities in highly myopic eyes, and it can be used for follow up of those patients to avoid advanced retinal damage.

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Corneal and Epithelial Thickness Mapping: Comparison of Swept-Source- and Spectral-Domain-Optical Coherence Tomography

Journal of Ophthalmology ◽

10.1155/2021/3444083 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Cristina Georgeon ◽

Ilanite Marciano ◽

Roxane Cuyaubère ◽

Otman Sandali ◽

Nacim Bouheraoua ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Corneal Thickness ◽

Spectral Domain ◽

Lamellar Keratoplasty ◽

Optical Coherence ◽

Swept Source ◽

Epithelial Thickness ◽

Spectral Domain Oct ◽

Anterior Lamellar Keratoplasty ◽

Sd Oct

Objective. To compare the results and repeatability of the corneal thickness (CT) and epithelial thickness (ET) maps provided by Swept-Source-Optical Coherence Tomography with those of Spectral-Domain-OCT in normal eyes. Methods. 30 normal eyes of 30 patients were assessed by 3 trained operators with SS-OCT and SD-OCT. Results. The central and minimum ET obtained with both devices were correlated: central ET, r = 0.86, p < 0.05 ; minimum ET, r = 0.72, p < 0.05 . Compared with SD-OCT, SS-OCT tended to underestimate these figures by 1.4 and 1.9 μm on average. The central and minimum CT obtained with both devices were strongly correlated: central CT, r = 0.994, p < 0.05 ; minimum CT, r = 0.995, p < 0.05 . SS-OCT tended to overestimate these figures by 11 and 14 μm on average. Repeatability was good for both devices with a mean coefficient of variation of measurements <6% for ET and <2% for CT. Interoperator variability (standard deviation and COV) was significantly higher for SS-OCT than for SD-OCT for all local epithelial thicknesses and significantly lower for the central CT and several local corneal thicknesses, whereas no significant differences between both technologies were found for the central and minimum ET and the minimum CT. Conclusion. SS-OCT and SD-OCT provide reproducible measurements of CT and ET in normal corneas with a strong correlation between both technologies. However, both technologies are not interchangeable when the main thickness parameters (i.e., central and minimum CT and minimum ET) are used for diagnosing early keratoconus or calculating the expected residual stromal bed thickness before corneal refractive surgery or anterior lamellar keratoplasty.

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Excess Glutamate May Cause Dilation of Retinal Blood Vessels in Glutamate/Aspartate Transporter-Deficient Mice

BioMed Research International ◽

10.1155/2019/6512195 ◽

2019 ◽

Vol 2019 ◽

pp. 1-11 ◽

Cited By ~ 1

Author(s):

Takayuki Gonome ◽

Yuting Xie ◽

Saeko Arai ◽

Kodai Yamauchi ◽

Natsuki Maeda-Monai ◽

...

Keyword(s):

Blood Vessels ◽

Outer Nuclear Layer ◽

Mouse Retina ◽

Ganglion Cell Complex ◽

Wild Type ◽

Time Points ◽

Retinal Blood Vessels ◽

In The Wild ◽

First Time ◽

Sd Oct

Purpose. To investigate the longitudinal findings of fundus features and spectral-domain optical coherence tomography (SD-OCT) to characterize the morphologic features in a mouse model of defective glutamate/aspartate transporter (GLAST−/− mice). Materials and Methods. The fundus findings and SD-OCT images were longitudinally recorded at five time points from postnatal (P) 22 to P156 in GLAST−/− mice. As a control wild type, age-matched C57BL/6J mice were employed. The mouse retina was subdivided into five layers, and the thickness of each layer was longitudinally measured by InSight® using SD-OCT pictures. The SD-OCT findings were compared with the histologic appearances. The diameter of the retinal blood vessels was measured by the ImageJ® software program using SD-OCT images. The data were statistically compared between both age-matched mouse groups. Results. The retinal blood vessels appeared more dilated in GLAST−/− mice than in wild-type mice. This tendency was statistically significant at all time points after P44 by analyses using SD-OCT images. The ganglion cell complex (GCC) and outer nuclear layer (ONL) were significantly thinner in GLAST−/− mice at all time points after P80 than in the wild-type mice. This tendency was more clearly indicated by SD-OCT than histologic sections. Discussion. In the present study, we found for the first time the dilation of the retinal blood vessels and the thinning of the ONL in GLAST−/− mice, in addition to the thinning of the GCC.

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COMPARATIVE STUDY OF RNFL THICKNESS USING SPECTRAL DOMAIN OCT AND VISUAL FIELD ANALYSIS USING HUMPHREY FIELD ANALYSER IN CASES OF POAG

10.36106/ijar/2704711 ◽

2021 ◽

pp. 62-64

Author(s):

Samra Wahaj Fatima ◽

M M M Baig ◽

Superna Mahender ◽

M. Geetanjali ◽

Mohammed Ather

Keyword(s):

Comparative Study ◽

Field Analysis ◽

Spectral Domain ◽

Automated Perimetry ◽

Care Hospital ◽

Slit Lamp ◽

Spectral Domain Oct ◽

Rnfl Thickness ◽

Field Analyser ◽

Sd Oct

Purpose: To compare RNLF structural changes by Spectral Domain- OCT and functional visual eld defects by automated perimetry in Primary Open Angle Glaucoma cases Materials And Methods: A prospective and comparative study was conducted to quantitatively measure the peripapillary retinal nerve ber layer thickness using SD-OCT and compared it with eld changes plotted by Humphrey Field analyser 24-2. The study was conducted at the department of Glaucoma of a tertiary eye care hospital for a period of one year. 60 eyes of 30 patients who diagnosed to have POAG between the age group of 40-65 were included in the study. Patients having substantial media opacity, Retinal pathology and who underwent intra ocular surgeries were excluded from the study. Informed consent obtained from patients who were included in the study. All were examined using Slit lamp, Snellen's chart, Applanation tonometer, Gonioscope, 90 D slit lamp biomicroscope to study Fundus oculi. Fields were plotted using Humphrey eld analyser 24-2 , RNFL thickness measured using SD-OCT. Results: 60 eyes of 30 patients 19 were males 11 were females. 14(23.33%) eyes showed normal visual elds but there was thinning of RNFL was noted in SD-OCT. 41 eyes (68.3%) had visual eld defects which corresponded to thinning of RNFL in that quadrant. 5 eyes (8.3%) showed advanced eld changes and had corresponding thinning of RNFL in that quadrant. Discussion: Results of this study shows a signicant difference in RNFL thickness among all three grades of glaucoma. It was observed that the average RNFL thickness value in moderate glaucoma (66.34 microns) and all quadrant thickness values were similar to Sihota et al study (RNFL-66.07 microns). The mean RNFL thickness +/- Sd (58 +/-5.52) in advanced glaucoma of present study were closely similar with the ndings of Sihota et al study (53.65 +/-14.2). Conclusion: It is concluded that RNFL thickness changes corresponds to Field changes plotted on Humphrey eld analyser in moderate glaucoma. Even in mild cases changes RNFL thickness is noted even though the elds plotted on Humphrey eld analyser doesn't show any changes. So RNFL thickness can be taken as Pre perimetric changes as diagnostic criteria for the diagnosis of POAG.

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Impact of segmentation errors and retinal blood vessels on retinal nerve fibre layer measurements using spectral-domain optical coherence tomography

Acta Ophthalmologica ◽

10.1111/aos.12762 ◽

2015 ◽

Vol 94 (3) ◽

pp. e211-e219 ◽

Cited By ~ 14

Author(s):

Cong Ye ◽

Marco Yu ◽

Christopher Kai-shun Leung

Keyword(s):

Optical Coherence Tomography ◽

Blood Vessels ◽

Nerve Fibre ◽

Retinal Nerve Fibre Layer ◽

Spectral Domain ◽

Optical Coherence ◽

Fibre Layer ◽

Retinal Blood Vessels ◽

Nerve Fibre Layer

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INCIDENCE OF CME AS MEASURED BY SPECTRAL DOMAIN OCT (SD - OCT) FOLLOWING EXTRA CAPS ULAR CATARACT EXTRACTION (ECCE)

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2015/1140 ◽

2015 ◽

Vol 4 (45) ◽

pp. 7833-7838

Author(s):

Dhwani Garg ◽

Neelima Mehrotra ◽

Arvind Ram ◽

Sharma B D ◽

Akhil Agarwal ◽

...

Keyword(s):

Cataract Extraction ◽

Spectral Domain ◽

Spectral Domain Oct ◽

Sd Oct

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Comparison of phase-resolved Doppler optical coherence tomography and optical coherence tomography angiography for measuring retinal blood vessels size

Journal of Computational Vision and Imaging Systems ◽

10.15353/vsnl.v3i1.167 ◽

2017 ◽

Vol 3 (1) ◽

Cited By ~ 1

Author(s):

Zohreh Hosseinaee ◽

Bingyao Tan ◽

Kostadinka Bizheva

Keyword(s):

Optical Coherence Tomography ◽

Blood Vessels ◽

Optical Coherence ◽

Acquisition Rate ◽

Doppler Oct ◽

Retinal Blood Vessels ◽

Significant Difference ◽

Arteries And Veins ◽

System Operating ◽

Sd Oct

The goal of this study was to compare two OCT-based methods for measuring retinal blood vessels size: Phase-resolved Doppler OCT (DOCT) and OCT angiography (OCTA). The study was conducted in rats (n= 6) using a SD-OCT system operating at 1060 nm with 92 kHz image acquisition rate. Arteries and veins were separated by the phase polarity. Results from this study showed that the venal diameters are significantly larger than the arterial diameters, and there is no significant difference in the vessel diameters measured by both methods.

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