Korrelation der quantitativen Metamorphopsiemessung und der zentralen Netzhautdicke bei diabetischem Makulaödem und altersassoziierter exsudativer Makuladegeneration

2018 ◽  
Vol 236 (07) ◽  
pp. 877-884 ◽  
Author(s):  
Daniela Claessens ◽  
Alexander K. Schuster
Keyword(s):  
Spectral Domain ◽  
Sich Eine ◽  
Spectral Domain Oct ◽  
Sd Oct

Zusammenfassung Hintergrund Zur Erfassung von Metamorphopsien steht im klinischen Alltag der Amsler-Test zur Verfügung. Dieser erfasst qualitativ Metamorphopsien, zur Quantifizierung von Metamorphopsien und als Verlaufskontrolle wurde der computerbasierte Test „AMD – A Metamorphopsia Detector®“ entwickelt. Das Ziel dieser Studie ist zu untersuchen, ob eine Korrelation zwischen zentraler Netzhautdicke (CRT, gemessen mittels Spectral Domain OCT) und quantifizierter Metamorphopsiemessung bei Patienten mit exsudativer altersassoziierter Makuladegeneration (AMD) und diabetischem Makulaödem (DMÖ) besteht. Material und Methoden 66 Augen von 66 Patienten (DMÖ: 19 [11 Männer, 8 Frauen; Alter 42 – 76 Jahre]; AMD: 47 [13 Männer, 34 Frauen; Alter 56 – 93 Jahre]) wurden in dieser explorativen Pilotstudie untersucht und in Hinblick auf das Vorliegen eines Makulaödems (zentrale 500-µm-Zone, Cirrus HD-OCT) klassifiziert. Bestkorrigierter monokularer Fernvisus (BCVA), Amsler-Test, Metamorphopsiemessung (AMD – A Metamorphopsia Detector) mit Angabe des Metamorphopsie-Index (MI), binokulare Ophthalmoskopie, SD-OCT mit Messung der zentralen Netzhautdicke (CRT) und ggf. Fluoreszenzangiografie wurden durchgeführt. Die Korrelation von CRT und MI wurde mittels Spearman-Korrelation geprüft. Ergebnisse BCVA bei DMÖ bzw. AMD betrug (logMAR) 0,27 (SD 0,3) bzw. 0,29 (SD 0,2). Bei Augen mit DMÖ zeigte sich eine Korrelation von MI und CRT mit rho = 0,88 (p < 0,001) und bei Augen mit AMD betrug rho = 0,56 (p < 0,001). Schlussfolgerung Die Korrelation von CRT und MI war bei DMÖ hoch und bei AMD moderat. Künftige Studien sollen untersuchen, ob sich die Metamorphopsiemessung zur Detektion einer Konversion in eine exsudative AMD eignet und ob dies eine Messung zur Verlaufskontrolle, ggf. als Selbsttest ermöglicht.

scholarly journals Assessment of Posterior Segment Using Spectral Domain OCT in Highly Myopic Eyes

2017 ◽  
Vol 11 (1) ◽  
pp. 334-345 ◽  
Author(s):  
Heba Radi AttaAllah ◽  
Ismail Ahmed Nagib Omar ◽  
Ahmed Shawkat Abdelhalim
Keyword(s):  
Social Sciences ◽  
Posterior Vitreous Detachment ◽  
Spectral Domain ◽  
Spherical Equivalent ◽  
Spearman Correlation ◽  
Spectral Domain Oct ◽  
Full Thickness Macular Hole ◽  
The Social ◽  
Sd Oct

Purpose: Spectral Domain Optical Coherence Tomography (SD-OCT) was used to evaluate retinal and vitreo-retinal changes that occur in highly myopic patients. Methods: This prospective study included 472 eyes of 472 patients suffering from high myopia (> -6.00 D), between May 2012 and December 2015. All patients were examined, using Cirrus HD OCT (Zeiss Cirrus TM HD-OCT model 4000), to detect any retinal or vitreo-retinal interface abnormalities. All obtained data was analyzed using Statistical Package for the Social Sciences software version 17 (SPSS Inc, Chicago, IL, USA) and the paired two-sided t-test. Bivariate correlations were performed between different parameters using the Spearman correlation coefficient (r). Results: Mean spherical equivalent (MSE) was -13.11± 4.35D. Mean axial length (AL) was 28.5±1.62 mm. Posterior vitreous detachment (PVD) was the most frequent OCT finding; representing 33.4% of the cases, 13.7% of them were associated with macular traction. A statistically significant positive correlation was found between AL and MTM, full thickness macular hole, PVD with traction, and dome shaped macula (r = 0.49 and P = 0.001, r = 0.422 and P = 0.0001, r = 0.25 and P = 0.03, r=0.475, P=0.001 respectively) Conclusion: OCT is a valuable tool in detecting retinal and vitreo-retinal interface abnormalities in highly myopic eyes, and it can be used for follow up of those patients to avoid advanced retinal damage.

scholarly journals Corneal and Epithelial Thickness Mapping: Comparison of Swept-Source- and Spectral-Domain-Optical Coherence Tomography

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Cristina Georgeon ◽  
Ilanite Marciano ◽  
Roxane Cuyaubère ◽  
Otman Sandali ◽  
Nacim Bouheraoua ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Thickness ◽  
Spectral Domain ◽  
Lamellar Keratoplasty ◽  
Optical Coherence ◽  
Swept Source ◽  
Epithelial Thickness ◽  
Spectral Domain Oct ◽  
Anterior Lamellar Keratoplasty ◽  
Sd Oct

Objective. To compare the results and repeatability of the corneal thickness (CT) and epithelial thickness (ET) maps provided by Swept-Source-Optical Coherence Tomography with those of Spectral-Domain-OCT in normal eyes. Methods. 30 normal eyes of 30 patients were assessed by 3 trained operators with SS-OCT and SD-OCT. Results. The central and minimum ET obtained with both devices were correlated: central ET, r = 0.86, p < 0.05 ; minimum ET, r = 0.72, p < 0.05 . Compared with SD-OCT, SS-OCT tended to underestimate these figures by 1.4 and 1.9 μm on average. The central and minimum CT obtained with both devices were strongly correlated: central CT, r = 0.994, p < 0.05 ; minimum CT, r = 0.995, p < 0.05 . SS-OCT tended to overestimate these figures by 11 and 14 μm on average. Repeatability was good for both devices with a mean coefficient of variation of measurements <6% for ET and <2% for CT. Interoperator variability (standard deviation and COV) was significantly higher for SS-OCT than for SD-OCT for all local epithelial thicknesses and significantly lower for the central CT and several local corneal thicknesses, whereas no significant differences between both technologies were found for the central and minimum ET and the minimum CT. Conclusion. SS-OCT and SD-OCT provide reproducible measurements of CT and ET in normal corneas with a strong correlation between both technologies. However, both technologies are not interchangeable when the main thickness parameters (i.e., central and minimum CT and minimum ET) are used for diagnosing early keratoconus or calculating the expected residual stromal bed thickness before corneal refractive surgery or anterior lamellar keratoplasty.

COMPARATIVE STUDY OF RNFL THICKNESS USING SPECTRAL DOMAIN OCT AND VISUAL FIELD ANALYSIS USING HUMPHREY FIELD ANALYSER IN CASES OF POAG

2021 ◽  
pp. 62-64
Author(s):  
Samra Wahaj Fatima ◽  
M M M Baig ◽  
Superna Mahender ◽  
M. Geetanjali ◽  
Mohammed Ather
Keyword(s):  
Comparative Study ◽  
Field Analysis ◽  
Spectral Domain ◽  
Automated Perimetry ◽  
Care Hospital ◽  
Slit Lamp ◽  
Spectral Domain Oct ◽  
Rnfl Thickness ◽  
Field Analyser ◽  
Sd Oct

Purpose: To compare RNLF structural changes by Spectral Domain- OCT and functional visual eld defects by automated perimetry in Primary Open Angle Glaucoma cases Materials And Methods: A prospective and comparative study was conducted to quantitatively measure the peripapillary retinal nerve ber layer thickness using SD-OCT and compared it with eld changes plotted by Humphrey Field analyser 24-2. The study was conducted at the department of Glaucoma of a tertiary eye care hospital for a period of one year. 60 eyes of 30 patients who diagnosed to have POAG between the age group of 40-65 were included in the study. Patients having substantial media opacity, Retinal pathology and who underwent intra ocular surgeries were excluded from the study. Informed consent obtained from patients who were included in the study. All were examined using Slit lamp, Snellen's chart, Applanation tonometer, Gonioscope, 90 D slit lamp biomicroscope to study Fundus oculi. Fields were plotted using Humphrey eld analyser 24-2 , RNFL thickness measured using SD-OCT. Results: 60 eyes of 30 patients 19 were males 11 were females. 14(23.33%) eyes showed normal visual elds but there was thinning of RNFL was noted in SD-OCT. 41 eyes (68.3%) had visual eld defects which corresponded to thinning of RNFL in that quadrant. 5 eyes (8.3%) showed advanced eld changes and had corresponding thinning of RNFL in that quadrant. Discussion: Results of this study shows a signicant difference in RNFL thickness among all three grades of glaucoma. It was observed that the average RNFL thickness value in moderate glaucoma (66.34 microns) and all quadrant thickness values were similar to Sihota et al study (RNFL-66.07 microns). The mean RNFL thickness +/- Sd (58 +/-5.52) in advanced glaucoma of present study were closely similar with the ndings of Sihota et al study (53.65 +/-14.2). Conclusion: It is concluded that RNFL thickness changes corresponds to Field changes plotted on Humphrey eld analyser in moderate glaucoma. Even in mild cases changes RNFL thickness is noted even though the elds plotted on Humphrey eld analyser doesn't show any changes. So RNFL thickness can be taken as Pre perimetric changes as diagnostic criteria for the diagnosis of POAG.

scholarly journals INCIDENCE OF CME AS MEASURED BY SPECTRAL DOMAIN OCT (SD - OCT) FOLLOWING EXTRA CAPS ULAR CATARACT EXTRACTION (ECCE)

2015 ◽  
Vol 4 (45) ◽  
pp. 7833-7838
Author(s):  
Dhwani Garg ◽  
Neelima Mehrotra ◽  
Arvind Ram ◽  
Sharma B D ◽  
Akhil Agarwal ◽  
...  
Keyword(s):  
Cataract Extraction ◽  
Spectral Domain ◽  
Spectral Domain Oct ◽  
Sd Oct

scholarly journals Spectral-Domain Optical Coherence Tomography for Glaucoma Diagnosis

2015 ◽  
Vol 9 (1) ◽  
pp. 68-77 ◽  
Author(s):  
Carolina P.B Gracitelli ◽  
Ricardo Y Abe ◽  
Felipe A Medeiros
Keyword(s):  
Structural Damage ◽  
Neural Tissue ◽  
Spectral Domain ◽  
Macular Area ◽  
Fiber Layer ◽  
Spectral Domain Oct ◽  
Glaucoma Diagnosis ◽  
Recent Attention ◽  
Objective Quantification ◽  
Sd Oct

Identification of structural damage to the optic nerve and retinal nerve fiber layer (RNFL) is an essential component of diagnosis and management of glaucoma. The introduction of spectral-domain OCT (SD-OCT) has allowed objective quantification of damage to these structures with unprecedented resolution. In addition, recent attention has been directed towards imaging the macular area for quantifying loss of neural tissue caused by the disease. Many studies have evaluated and compared the diagnostic accuracies of a variety of parameters that can be obtained from imaging these areas of the ocular fundus. In this article, we critically review the existing literature evaluating the diagnostic accuracy of SD-OCT in glaucoma and we discuss issues related to how SD-OCT results should be incorporated into clinical practice.

Diagnostic precision of a microscope-integrated intraoperative OCT device in patients with epiretinal membranes

2017 ◽  
Vol 28 (3) ◽  
pp. 329-332 ◽  
Author(s):  
Christoph Leisser ◽  
Nino Hirnschall ◽  
Christoph Hackl ◽  
Birgit Döller ◽  
Ralph Varsits ◽  
...  
Keyword(s):  
Intraoperative Imaging ◽  
Diagnostic Technique ◽  
Spectral Domain ◽  
Vitreomacular Traction ◽  
Interobserver Reproducibility ◽  
Epiretinal Membranes ◽  
Spectral Domain Oct ◽  
Macular Holes ◽  
Imaging Results ◽  
Sd Oct

Purpose: Preoperative and postoperative optical coherence tomography (OCT) of macular pathologies can be regarded as the gold standard diagnostic technique, providing detailed information on the microstructures of the macula for planning the surgical procedure and comparing improvements after surgery in the follow-up period. Intraoperative use of OCT is a novel application to support surgeons during macular surgery. The aim of this study was to examine the diagnostic precision of a microscope-integrated intraoperative spectral-domain OCT (i-OCT) device and compare imaging results to a stand-alone spectral-domain OCT (SD-OCT) device. Methods: This prospective study included 41 eyes of 41 patients scheduled for pars plana vitrectomy with membrane peeling due to an idiopathic epiretinal membrane (ERM). Intraoperative imaging with the i-OCT device was performed at the beginning of the surgery and compared to preoperative SD-OCT images. Results: Preoperative and intraoperative SD-OCT evaluations showed high intraobserver and interobserver reproducibility for the presence of ERM, lamellar macular hole, and vitreomacular traction. For intraretinal cystoid changes, intraobserver and interobserver reproducibility for both OCTs was rather poor, mainly due to microcystic changes. Conclusions: Intraoperative spectral-domain OCT offers high reproducibility regarding the visibility of ERM, lamellar macular holes, and vitreomacular traction. Microcystic changes cause discrepancies in interpretation, often simply diagnosed as retinal thickening.

scholarly journals Spectral Domain OCT Documented Resolution of Pseudophakic Cystoid Macular Edema after Intravitreal Triamcinolone

2010 ◽  
Vol 2 ◽  
pp. OED.S3671
Author(s):  
Ravi K Murthy ◽  
Kakarla V. Chalam
Keyword(s):  
Macular Edema ◽  
Cystoid Macular Edema ◽  
Spectral Domain ◽  
Vascular Endothelial ◽  
Intravitreal Triamcinolone ◽  
Cross Sectional ◽  
Spectral Domain Oct ◽  
Endothelial Growth Factor ◽  
Stratus Oct ◽  
Sd Oct

Cystoid macular edema (CME) is an important cause of visual loss after cataract surgery. Treatment is usually with topical anti-inflammatory agents, with anti-vascular endothelial growth factor agents and steroids used intravitreally in resistant cases. Even though time-domain Stratus OCT can quantify the macular thickness, it cannot prognosticate visual outcomes due to the poor resolution of images, especially the outer segment-inner segment junction. Spectral-domain OCT (SD-OCT) by its ability to acquire large number of images in a short span of time provides high resolution cross-sectional images of the retina, which not only highlights the underlying pathological changes, but in addition can prognosticate visual recovery. We describe pre and post SD-OCT features of a case of refractory CME who was treated with intravitreal triamcinolone actetonide.

scholarly journals Clinical and Spectral-Domain Optical Coherence Tomography Findings of Patients with Incomplete Visual Recovery after Anatomically Successful Retinal Detachment Surgery

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Miltiadis K. Tsilimbaris ◽  
Aikaterini Chalkia ◽  
Chrysanthi Tsika ◽  
Anastasios Anastasakis ◽  
Georgios A. Kontadakis
Keyword(s):  
Retinal Detachment ◽  
Spectral Domain ◽  
Strongly Correlated ◽  
Visual Recovery ◽  
Retinal Detachment Surgery ◽  
Spectral Domain Oct ◽  
Pars Plana ◽  
Oct Imaging ◽  
Sd Oct

Purpose. To identify causes of incomplete visual recovery in patients with anatomically successful retinal detachment surgery.Methods. This was a retrospective study of 61 eyes of 61 patients with at least 12-month follow-up and complete preoperative, intraoperative, and postoperative record. Postoperative visual acuity (VA) more than 0.18 logMAR was considered as incomplete visual recovery. Complete ophthalmic examination and Spectral-Domain OCT (SD-OCT) imaging were performed at last follow-up.Results. Twenty-nine eyes (47.5%) had a postoperative VA < 0.18 logMAR and 32 eyes (52.5%) had a postoperative VA ≥ 0.18 logMAR. Mean follow-up was 32.8 ± 17.3 months. Incomplete visual recovery was strongly correlated with presence of macular pathology (P= 0.002), a detached macula preoperatively (P= 0.02), retinotomy (P= 0.025), and pars plana vitrectomy and use of silicon oil as a tamponade agent (P= 0.009). Also, although there was a strong correlation between ellipsoid zone disruption and incomplete visual recovery, a distinct, more course pathology could be identified in all cases of poor visual recovery related to edema, thickening, or atrophy of the macula.Conclusion. The careful postoperative evaluation of the macula using biomicroscopy and SD-OCT can help in diagnosis of alterations that can be associated with incomplete visual recovery.

scholarly journals Hyperreflective Intraretinal Spots in Diabetics without and with Nonproliferative Diabetic Retinopathy: AnIn VivoStudy Using Spectral Domain OCT

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Stela Vujosevic ◽  
Silvia Bini ◽  
Giulia Midena ◽  
Marianna Berton ◽  
Elisabetta Pilotto ◽  
...  
Keyword(s):  
Normal Subjects ◽  
Spectral Domain ◽  
Diabetic Patients ◽  
Retinal Layer ◽  
Inner Retina ◽  
Spectral Domain Oct ◽  
Diabetic Retina ◽  
Inner Limiting Membrane ◽  
Ophthalmologic Examination ◽  
Sd Oct

Purpose. To evaluate the presence of hyperreflective spots (HRS) in diabetic patients without clinically detectable retinopathy (no DR) or with nonproliferative mild to moderate retinopathy (DR) without macular edema, and compare the results to controls.Methods. 36 subjects were enrolled: 12 with no DR, 12 with DR, and 12 normal subjects who served as controls. All studied subjects underwent full ophthalmologic examination and spectral domain optical coherence tomography (SD-OCT). SD-OCT images were analyzed to measure and localize HRS. Each image was analyzed by two independent, masked examiners.Results. The number of HRS was significantly higher in both diabetics without and with retinopathy versus controls (P<0.05) and in diabetics with retinopathy versus diabetics without retinopathy (P<0.05). The HRS were mainly located in the inner retina layers (inner limiting membrane, ganglion cell layer, and inner nuclear layer). The intraobserver and interobserver agreement was almost perfect (κ>0.9).Conclusions. SD-OCT hyperreflective spots are present in diabetic eyes even when clinical retinopathy is undetectable. Their number increases with progressing retinopathy. Initially, HRS are mainly located in the inner retina, where the resident microglia is present. With progressing retinopathy, HRS reach the outer retinal layer. HRS may represent a surrogate of microglial activation in diabetic retina.

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