Examining the Effect of Mitochondrial Fission and Fusion Events on the Heart
Mitochondria constitute an integral structural and functional part of the cardiac muscle. The heart muscle relies on the mitochondrial production of fatty acids and ATP as sources of energy during different stages of human growth and development. New mitochondria are created from existing ones by a process called mitochondrial biogenesis which involves both fusion and fission events controlled by a bevy of proteins such as Drp1, OPA1, Mfn1, and Mfn2. In this chapter, we examine the role of these mitochondrial fission and fusion proteins in regulating various heart diseases, particularly, reperfusion injury, dilated cardiomyopathy, and heart failure. It is our intent to examine whether any of these proteins may serve as future candidates for cardiovascular therapy.