Examining the Effect of Mitochondrial Fission and Fusion Events on the Heart

Author(s):  
Ashim Malhotra ◽  
Shivani Soni

Mitochondria constitute an integral structural and functional part of the cardiac muscle. The heart muscle relies on the mitochondrial production of fatty acids and ATP as sources of energy during different stages of human growth and development. New mitochondria are created from existing ones by a process called mitochondrial biogenesis which involves both fusion and fission events controlled by a bevy of proteins such as Drp1, OPA1, Mfn1, and Mfn2. In this chapter, we examine the role of these mitochondrial fission and fusion proteins in regulating various heart diseases, particularly, reperfusion injury, dilated cardiomyopathy, and heart failure. It is our intent to examine whether any of these proteins may serve as future candidates for cardiovascular therapy.

2016 ◽  
pp. 999-1025
Author(s):  
E. William Ebomoyi

This chapter focused on the impact of phenomenology, epigenome, and epigenetic factors in the growth and development of school-age children. The biological and social determinants of human development were explored. Inevitably, the inherited gene–chromosomes play a significant role in human growth and development. The academic institutions are set up to facilitate the process of nurturing school-age children, not only in their physical growth and development, but also in their social adjustment to enable them to become fully functioning adults. By far most important, we explored the role of epigenetics in human aging process, since numerous existential events as weathering, stress, nutrition inclement weather, and chemical/pesticides in our environment contribute to aging.


This chapter focused on the impact of phenomenology, epigenome, and epigenetic factors in the growth and development of school-age children. The biological and social determinants of human development were explored. Inevitably, the inherited gene–chromosomes play a significant role in human growth and development. The academic institutions are set up to facilitate the process of nurturing school-age children, not only in their physical growth and development, but also in their social adjustment to enable them to become fully functioning adults. By far most important, we explored the role of epigenetics in human aging process, since numerous existential events as weathering, stress, nutrition inclement weather, and chemical/pesticides in our environment contribute to aging.


2021 ◽  
pp. 106648072110239
Author(s):  
Robyn T. Simmons ◽  
Kelly Coker ◽  
Brooks B. Hanks ◽  
Donna S. Sheperis ◽  
Lynn Bohecker

Aspects of human growth and development have been studied since the inception of psychology as a field of science. The impact of the quality of mothering on children has been highly researched. However, little attention has been paid in the professional literature to the experiences of mothers as their children move through developmental stages. The focus of this hermeneutic phenomenology study was to investigate how mothers’ experiences of their child's growth and development changed her perceptions of her identity and herself. Participants were eight women who had launched the oldest child from the home within the last 2 years. Extensive data analysis and triangulation procedures were conducted to develop themes. Universal themes experienced by all participants were categorized as internal (questioning, comparison, being purposeful, and feeling supported) and external (experiencing joy). Some participant experiences were influenced by incidental themes such as subsequent children, expectations versus reality, and spirituality. Participants’ experience of their mothering role was also impacted by the process of letting go through the developmental progression of their children. Clinical implications are discussed.


2017 ◽  
Vol 27 (2) ◽  
pp. 128 ◽  
Author(s):  
Luiz Antônio Tavares Neves

  Brazil has made a wide development and contribution in the field of Public Health. These contributions have maximized public health decision-making, which is a factor of great importance for the maintenance of health of a given population, either in the prevention of disease, as is the case of immunizations or with actions in Health Promotion, improving the quality of life of the affected population. Thus, the Journal of Human Growth and Development has contributed enormously to the dissemination of knowledge, not only in Brazil but also in the world making a major effort with its publications in English which is the preferred language of the modern scientific world. It was evidenced the importance of research in the investigation of better ways to obtain the public health of a given community, bringing discussion of themes that involve aspects of human growth and development such as nutritional aspects, sexuality, motor development, covering situations and diseases as obesity, cerebral palsy, dyslexia and violence. The Journal of Human Growth and Development has maintained the tradition of approaching the different aspects that involve clinical practice for people and for Public Health. 


1999 ◽  
Vol 21 (3) ◽  
pp. 9-11
Author(s):  
Estrella Posada ◽  
Antonio Berdasco

In 1969 the Ministry of Public Health (MINSAP) of Cuba initiated a program to reduce infant mortality, one measure of the quality of life, in 1969. The program developed during the 1970s and while infant mortality was reduced, it became desirable to add other measures directly related to the health of the population to the program. Sampled periodically, characteristics of growth and the development, were selected as additional indicators of the health of the population.


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