Bifurcation Analysis of a Model Accounting for the 14-3-3s Signalling Compartmentalisation

Quality Assurance in Healthcare Service Delivery, Nursing and Personalized Medicine ◽

10.4018/978-1-61350-120-7.ch004 ◽

2012 ◽

pp. 61-70

Author(s):

S. Nikolov ◽

J. Vera ◽

O. Wolkenhauer

Keyword(s):

Mathematical Model ◽

Phase Portrait ◽

Bifurcation Analysis ◽

Subcellular Localisation ◽

Loss Of Stability ◽

Cycle Arrest ◽

Reversible Loss ◽

Analytical Tools

Bifurcation theory studies the qualitative changes in the phase portrait when we vary the parameters of the system. In this book chapter we adapt and extend a mathematical model accounting for the subcellular localisation of 14-3-3s, a protein involved in cell cycle arrest and the regulation of apoptosis. The model is analysed with analytical tools coming from Lyapunov-Andronov theory, and our analytical calculations predict that soft (reversible) loss of stability takes place.

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Bifurcation Analysis of a Model Accounting for the 14-3-3s Signalling Compartmentalisation

Bioinformatics ◽

10.4018/978-1-4666-3604-0.ch046 ◽

2013 ◽

pp. 851-859

Author(s):

S. Nikolov ◽

J. Vera ◽

O. Wolkenhauer

Keyword(s):

Mathematical Model ◽

Phase Portrait ◽

Bifurcation Analysis ◽

Subcellular Localisation ◽

Loss Of Stability ◽

Cycle Arrest ◽

Reversible Loss ◽

Analytical Tools

Bifurcation theory studies the qualitative changes in the phase portrait when we vary the parameters of the system. In this book chapter we adapt and extend a mathematical model accounting for the subcellular localisation of 14-3-3s, a protein involved in cell cycle arrest and the regulation of apoptosis. The model is analysed with analytical tools coming from Lyapunov-Andronov theory, and our analytical calculations predict that soft (reversible) loss of stability takes place.

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PPAR-γ ligands induce G1 cell cycle arrest and reduce ornithine decarboxylase activity of human Barrett's adenocarcinoma cells

Gastroenterology ◽

10.1016/s0016-5085(01)82062-x ◽

2001 ◽

Vol 120 (5) ◽

pp. A415-A415

Author(s):

T TAKASHIMA ◽

Y FUJIWARA ◽

K HIGUCHI ◽

T ARAKAWA ◽

Y YANO ◽

...

Keyword(s):

Cell Cycle Arrest ◽

Ornithine Decarboxylase ◽

Decarboxylase Activity ◽

Ornithine Decarboxylase Activity ◽

Ppar Γ ◽

Cycle Arrest ◽

Adenocarcinoma Cells ◽

Barrett’S Adenocarcinoma ◽

G1 Cell Cycle Arrest

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Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl–2 inhibitor HA14–1

Zeitschrift für Gastroenterologie ◽

10.1055/s-2004-831695 ◽

2004 ◽

Vol 42 (08) ◽

Author(s):

A Sutter ◽

K Maaser ◽

P Grabowski ◽

M Höpfner ◽

A Krahn ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Cycle Arrest ◽

Benzodiazepine Receptor ◽

Carcinoma Cells ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Cycle Arrest ◽

Human Hepatocellular Carcinoma Cells

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Helicobacter pylori induces cell cycle arrest of T-lymphocytes

Zeitschrift für Gastroenterologie ◽

10.1055/s-2005-919822 ◽

2005 ◽

Vol 43 (05) ◽

Author(s):

M Gerhard ◽

C Schmees ◽

R Rad ◽

P Voland ◽

T Treptau ◽

...

Keyword(s):

Helicobacter Pylori ◽

T Lymphocytes ◽

Cell Cycle Arrest ◽

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Cell cycle arrest and apoptosis induction in human prostate cancer cell lines (PC-346C, LNCaP and PC-3) by the green tea ingredient EGCG (Epigallocatechingallate)

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2006-932978 ◽

2006 ◽

Vol 114 (S 1) ◽

Author(s):

T Nishino ◽

T Schulz ◽

M Schoenfelder ◽

H Michna ◽

M Tenniswood

Keyword(s):

Prostate Cancer ◽

Cell Cycle Arrest ◽

Green Tea ◽

Prostate Cancer Cell ◽

Human Prostate Cancer ◽

Apoptosis Induction ◽

Human Prostate Cancer Cell ◽

Prostate Cancer Cell Lines ◽

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Involvement of G2/M Cell Cycle Arrest and the Mitochondrial Pathway in Boletopsis leucomelaena (Pers.) Fayod (Agaricomycetideae) Lectin-Induced Apoptosis of Human Leukemia U937 Cells

International Journal of Medicinal Mushrooms ◽

10.1615/intjmedmushr.v7.i12.190 ◽

2005 ◽

Vol 7 (1-2) ◽

pp. 201-212 ◽

Author(s):

Yu Koyama ◽

Takuji Suzuki ◽

Akane Kajiya ◽

Mamoru Isemura

Keyword(s):

Cell Cycle Arrest ◽

Mitochondrial Pathway ◽

Human Leukemia ◽

M Cell ◽

Cycle Arrest ◽

Induced Apoptosis

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Mechanisms of interferon-induced cell cycle arrest

Frontiers in Bioscience ◽

10.2741/a527 ◽

2000 ◽

Vol 5 (3) ◽

pp. d479-487 ◽

Author(s):

Dan Grandér

Keyword(s):

Cell Cycle Arrest ◽

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Faculty Opinions recommendation of Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1009998.141066 ◽

2002 ◽

Author(s):

Guy Laurent

Keyword(s):

Protein Kinase ◽

Cell Cycle Arrest ◽

Mitogen Activated Protein Kinase ◽

Kinase Activation ◽

Cycle Arrest ◽

Protein Kinase Activation ◽

Mitogen Activated Protein ◽

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Faculty Opinions recommendation of Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1066778.524718 ◽

2007 ◽

Author(s):

Anindya Dutta

Keyword(s):

Cell Cycle Arrest ◽

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Faculty Opinions recommendation of Pause-and-stop: the effects of osmotic stress on cell proliferation during early leaf development in Arabidopsis and a role for ethylene signaling in cell cycle arrest.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11049958.12003056 ◽

2011 ◽

Author(s):

Tomomichi Fujita

Keyword(s):

Cell Proliferation ◽

Osmotic Stress ◽

Cell Cycle Arrest ◽

Leaf Development ◽

Ethylene Signaling ◽

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