Improving quality assurance and providing effective healthcare are some of the most important aims of information and communication technologies (ICT). This chapter presents a novel solution to improve quality assurance in drugs delivery, i.e., reduce clinical errors caused by drug interaction and dose. For that purpose, we have proposed an innovative system based on Internet of things for the drugs identification. Internet of things (IoT) is one of the latest advances in ICT, providing a global connectivity and management of sensors, devices, users, and information. Our contribution is a solution to examine drug related problems based on IoT technologies, i.e. smart phones and Web, to support ubiquitous access, 6LoWPAN technology to support ubiquitous data collection of patients, sensors and hospitals, and RFID/NFC to support global identification. These technologies offer a wide range of applications in healthcare, which improves the quality of services, reduces mistakes, and even detects health anomalies from vital signs. This chapter presents how IoT technology is applied in a pharmaceutical system to examine drugs in order to detect Adverse Drug Reactions (ADRs), harmful effects of pharmaceutical excipients, allergies, complications and contraindications related with liver and renal defects, and harmful side effects during pregnancy or lactation. Thereby, the system provides an enhanced approach assisting physicians in clinical decisions and drug prescribing. The solution presented is based on NFC (Near Field Communication), RFID (Radio Frequency Identification), and barcode identification technologies, which have been integrated in common devices such as smart-phones, PDAs, and PCs. In addition, a remote knowledge-based system based ontologies and rules-engine, has been built to define an intelligent drugs checker, which we have defined as Pharmaceutical Intelligent Information System, where the drug identifies collected from the RFID/NFC tag or barcode is checked, in order to detect whether the identified drug is suitable with respect to the patient’s health record.