Grid Architecture and Components in Diagnostic Pathology

2010 ◽  
pp. 105-116
Author(s):  
Gloria Bueno García ◽  
Marcial García Rojo ◽  
Roberto González Morales ◽  
Oscar Déniz Suárez ◽  
Jesús García González
Keyword(s):  
Large Scale ◽  
Automated Image Analysis ◽  
Image Analysis System ◽  
Web Based ◽  
Diagnostic Pathology ◽  
Data Intensive ◽  
Power Resources ◽  
Data Application ◽  
Health Related ◽  
Analysis System

The Grid vision has been described as a world in which computational power (resources, services, data) is as readily available as different utilities. They are available to users by means of computational, data, application, information and knowledge services at different levels and areas. These services can interact to perform specified tasks in an efficient and secure way. Their main applications include large-scale computational and data intensive problems in science and engineering. Therefore, Grids are likely to have a deep impact on health related applications. Moreover, they seem to be suitable for tissue-based diagnosis. This chapter analyzes the general structures and functions of a Grid environment implemented for tissue-based diagnosis on digital images. Moreover, it describes the web-based automated image analysis system developed by the authors for diagnostic pathology.

Automated image analysis of Euglena gracilis Klebs (Euglenophyta) for measuring sublethal effects of three model contaminants

2012 ◽  
Vol 66 (8) ◽  
pp. 1708-1715 ◽  
Author(s):  
I. Netto ◽  
V. Bostan ◽  
L. McCarthy ◽  
A. Laursen ◽  
K. Gilbride ◽  
...  
Keyword(s):  
Image Analysis ◽  
Euglena Gracilis ◽  
Cell Shape ◽  
Early Warning Systems ◽  
Visual Observation ◽  
Automated Image Analysis ◽  
Swimming Velocity ◽  
Image Analysis System ◽  
Behavioural Changes ◽  
Analysis System

The short-term impacts of atrazine (herbicide), tributyltin (organometal) and copper on the behaviour of Euglena gracilis Klebs (Euglenophyta) were assessed. First, the ECOTOX automated image analysis system was used, which measured swimming velocity, cell shape, percentage of cells swimming upwards, and randomness of swimming. Next, visual observation by microscopy was used to measure percentage of cell motility and cell shape. Behavioural changes can be used as an indicator of stress in less than 24 h, potentially making them suitable for inclusion in early-warning systems for water quality. Findings indicate that E. gracilis is a very sensitive organism to copper, showing inhibition of motility with visual observation at 0.8 μmol/L within 1 h. The image analysis system was in general less sensitive than visual observation for detecting behavioural changes after incubation in copper. In contrast, after exposure to organic contaminants atrazine and tributyltin, the ECOTOX system detected small changes in the number of cells swimming upwards (antigravitactic behaviour) at higher concentrations.

An automated image analysis system for major maceral group analysis in coals

Fuel ◽  
1994 ◽  
Vol 73 (11) ◽  
pp. 1729-1734 ◽  
Author(s):  
Edward Lester ◽  
Martin Allen ◽  
Michael Cloke ◽  
Nick J. Miles
Keyword(s):  
Image Analysis ◽  
Group Analysis ◽  
Automated Image Analysis ◽  
Image Analysis System ◽  
Analysis System

Primary Cutaneous Small/Medium CD4+ T-Cell Lymphomas: A Heterogeneous Group of Tumors With Different Clinicopathologic Features and Outcome

2008 ◽  
Vol 26 (20) ◽  
pp. 3364-3371 ◽  
Author(s):  
Adriana Garcia-Herrera ◽  
Luis Colomo ◽  
Mireia Camós ◽  
Joaquín Carreras ◽  
Olga Balague ◽  
...  
Keyword(s):  
T Cell ◽  
Prognostic Significance ◽  
Heterogeneous Group ◽  
Automated Image Analysis ◽  
Proliferation Index ◽  
Image Analysis System ◽  
Ki 67 ◽  
Cutaneous Lymphomas ◽  
Analysis System

Purpose To define the clinical and pathologic characteristics of primary cutaneous small/medium CD4+ T-cell lymphoma (PCSM-TCL) and identify parameters of prognostic significance. Patients and Methods We have investigated 24 patients with primary cutaneous lymphomas composed of small/medium mature T-cells with a βF1, CD3, CD4+ and/or noncytotoxic, CD8– and CD30– phenotype. The proliferation index and CD8+ infiltrating cells were quantified with an automated image analysis system. Results Sixteen patients presenting with solitary or localized plaques or small nodules (< 3 cm) had an indolent course. Only three patients experienced repeated cutaneous relapses, and none of them died as a result of the disease after 1 to 168 months (median, 17 months) of follow-up. The tumors had a low proliferation (median Ki-67, 9% ± 5%) and an intense infiltrate of reactive CD8+ (median, 20% ± 11.7%). Five patients presenting with rapidly evolving large tumors or nodules (≥ 5 cm) had an aggressive disease and died with extracutaneous dissemination 18 to 36 months after diagnosis (median, 23 months). These tumors had a significantly higher proliferation (median Ki-67, 22% ± 11.3%; P < .05) and lower number of infiltrating CD8+ (median, 1% ± 3%; P < .05) than the previous group. A third group of three patients had a peculiar clinical presentation with multifocal relapsing lesions without extracutaneous dissemination after a long period of follow-up ranging from 41 to 92 months. Histologically, these cases had an intense infiltrate of eosinophils. Conclusion PCSM-TCL is a heterogeneous group of tumors with differentiated clinical and pathological characteristics with impact in the outcome of the patients.

scholarly journals Quantitative Automated Image Analysis System with Automated Debris Filtering for the Detection of Breast Carcinoma Cells

2011 ◽  
Vol 55 (3) ◽  
pp. 271-280 ◽  
Author(s):  
David T. Martin ◽  
Sergio Sandoval ◽  
Casey N. Ta ◽  
Manuel E. Ruidiaz ◽  
Maria Jose Cortes-Mateos ◽  
...  
Keyword(s):  
Image Analysis ◽  
Breast Carcinoma ◽  
Carcinoma Cells ◽  
Automated Image Analysis ◽  
Image Analysis System ◽  
Breast Carcinoma Cells ◽  
Analysis System
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