Guided Bone Regeneration, Platelet Rich Plasma and Low-Intensity Ultrasound Irradiation for Dental Implants

2006 ◽  
pp. 171-180
Author(s):  
Kuniteru Nagahara ◽  
Toshiichiro Tanabe ◽  
Noriaki Ito ◽  
Motohiko Nagayama ◽  
Kota Takagi ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Dental Implants ◽  
Platelet Rich Plasma ◽  
Ultrasound Irradiation ◽  
Guided Bone Regeneration ◽  
Low Intensity ◽  
Low Intensity Ultrasound

Platelet-rich plasma may not provide any additional effect when associated with guided bone regeneration around dental implants in dogs

2007 ◽  
Vol 18 (5) ◽  
pp. 649-654 ◽  
Author(s):  
Bruno César de Vasconcelos Gurgel ◽  
Patrícia Furtado Gonçalves ◽  
Suzana Peres Pimentel ◽  
Gláucia Maria Bovi Ambrosano ◽  
Francisco Humberto Nociti Júnior ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Dental Implants ◽  
Platelet Rich Plasma ◽  
Guided Bone Regeneration

Guided Bone Regeneration, Platelet Rich Plasma and Low-Intensity Ultrasound Irradiation for Dental Implants

2006 ◽  
Vol 49 ◽  
pp. 171-180 ◽  
Author(s):  
Kuniteru Nagahara ◽  
Toshiichiro Tanabe ◽  
Noriaki Ito ◽  
Motohiko Nagayama ◽  
Kota Takagi ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Dental Implant ◽  
Platelet Rich Plasma ◽  
Guided Bone Regeneration ◽  
Autogenous Bone ◽  
Bone Block ◽  
Bone Augmentation ◽  
Basic Study ◽  
Low Intensity

Because a concept of an osteointegrated dental implant system was established, prognosis of a dental implant at treatment improved and the treatment of restoration for missing teeth was changed. However, a dental implant treatment into atrophic jaw bone requires bone augmentation, obviously. At this time, we studied for the purpose of establishing the evidence of each method for clinical application of these bone augmentation method, such as guided bone regeneration (GBR), and autogenous bone block graft (BBG). In addition, we pursued the basic study of the evidence about the bone formation with platelet rich plasma (PRP) which recognized the availability in clinic. Furthermore, we present the results of basic studies which we tested for the purpose of applying a low-intensity pulse ultrasound (LIPU) irradiation applied to a fracture treatment in orthopedics area to intra-oral area, specially the condition after implant placement. In the results of comparison with GBR site and BBG, the differences of labeling bands were observed with a fluorescence microscopy. There was much labeling bands on GBR sections in comparison with BBG. This meaning that the bone remodeling around implants at GBR site was more active than BBG site. And the new bone formation by PRP was identified on soft X-ray graphically at first week after PRP applied mandible bone defect (experimental side). At same region of first week specimen, we confirmed positive reactions of platelet derived growth factor

Additive manufacturing to assist prosthetically guided bone regeneration of atrophic maxillary arches

2015 ◽  
Vol 21 (6) ◽  
pp. 705-715 ◽  
Author(s):  
M. Fantini ◽  
F. De Crescenzio ◽  
L. Ciocca ◽  
F. Persiani
Keyword(s):  
Additive Manufacturing ◽  
Bone Regeneration ◽  
Dental Implants ◽  
Surgical Intervention ◽  
Guided Bone Regeneration ◽  
Autogenous Bone ◽  
Bone Augmentation ◽  
Virtual Planning ◽  
Content Type ◽  
Fused Deposition

Purpose – The purpose of this paper is to describe two different approaches for manufacturing pre-formed titanium meshes to assist prosthetically guided bone regeneration of atrophic maxillary arches. Both methods are based on the use of additive manufacturing (AM) technologies and aim to limit at the minimal intervention the bone reconstructive surgery by virtual planning the surgical intervention for dental implants placement. Design/methodology/approach – Two patients with atrophic maxillary arches were scheduled for bone augmentation using pre-formed titanium mesh with particulate autogenous bone graft and alloplastic material. The complete workflow consists of four steps: three-dimensional (3D) acquisition of medical images and virtual planning, 3D modelling and design of the bone augmentation volume, manufacturing of biomodels and pre-formed meshes, clinical procedure and follow up. For what concerns the AM, fused deposition modelling (FDM) and direct metal laser sintering (DMLS) were used. Findings – For both patients, a post-operative control CT examination was scheduled to evaluate the progression of the regenerative process and verify the availability of an adequate amount of bone before the surgical intervention for dental implants placement. In both cases, the regenerated bone was sufficient to fix the implants in the planned position, improving the intervention quality and reducing the intervention time during surgery. Originality/value – A comparison between two novel methods, involving AM technologies are presented as viable and reproducible methods to assist the correct bone augmentation of atrophic patients, prior to implant placement for the final implant supported prosthetic rehabilitation.

Buccal bone thickness adjacent to virtual dental implants following guided bone regeneration

2019 ◽  
Vol 90 (6) ◽  
pp. 595-607 ◽  
Author(s):  
Daniel J. Phillips ◽  
Dane T. Swenson ◽  
Thomas M. Johnson
Keyword(s):  
Bone Regeneration ◽  
Dental Implants ◽  
Guided Bone Regeneration ◽  
Bone Thickness

scholarly journals Can the Macrogeometry of Dental Implants Influence Guided Bone Regeneration in Buccal Bone Defects? Histomorphometric and Biomechanical Analysis in Beagle Dogs

2019 ◽  
Vol 8 (5) ◽  
pp. 618 ◽  
Author(s):  
Manuel Fernández-Domínguez ◽  
Victor Ortega-Asensio ◽  
Elena Fuentes Numancia ◽  
Juan Aragoneses ◽  
Horia Barbu ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Dental Implants ◽  
Animal Study ◽  
Statistical Significance ◽  
Guided Bone Regeneration ◽  
Biomechanical Analysis ◽  
Implant Stability ◽  
Beagle Dogs ◽  
Implant Placement ◽  
Cervical Portion

The aim of this experimental animal study was to assess guided bone regeneration (GBR) and implant stability (ISQ) around two dental implants with different macrogeometries. Forty eight dental implants were placed within six Beagle dogs. The implants were divided into two groups (n = 24 per group): G1 group implants presented semi-conical macrogeometry, a low apical self-tapping portion, and an external hexagonal connection (whereby the cervical portion was bigger than the implant body). G2 group implants presented parallel walls macrogeometry, a strong apical self-tapping portion, and an external hexagonal connection (with the cervical portion parallel to the implant body). Buccal (mouth-related) defects of 2 mm (c2 condition) and 5 mm (c3 condition) were created. For the control condition with no defect (c1), implants were installed at crestal bone level. Eight implants in each group were installed under each condition. The implant stability quotient (ISQ) was measured immediately after implant placement, and on the day of sacrifice (3 months after the implant placement). Histological and histomorphometric procedures and analysis were performed to assess all samples, measuring crestal bone loss (CBL) and bone-to-implant contact (BIC). The data obtained were compared with statistical significance set at p < 0.05. The ISQ results showed a similar evolution between the groups at the two evaluation times, although higher values were found in the G1 group under all conditions. Within the limitations of this animal study, it may be concluded that implant macrogeometry is an important factor influencing guided bone regeneration in buccal defects. Group G1 showed better buccal bone regeneration (CBL) and BIC % at 3 months follow up, also parallel collar design can stimulate bone regeneration more than divergent collar design implants. The apical portion of the implant, with a stronger self-tapping feature, may provide better initial stability, even in the presence of a bone defect in the buccal area.

Vertical ridge augmentation with guided bone regeneration in association with dental implants: an experimental study in dogs

2007 ◽  
Vol 18 (1) ◽  
pp. 86-94 ◽  
Author(s):  
Massimo Simion ◽  
Christer Dahlin ◽  
Isabella Rocchietta ◽  
Andreas Stavropoulos ◽  
Raquel Sanchez ◽  
...  
Keyword(s):  
Experimental Study ◽  
Bone Regeneration ◽  
Dental Implants ◽  
Guided Bone Regeneration ◽  
Ridge Augmentation

scholarly journals A Synergistic Bactericidal Effect of Low-Frequency and Low-Intensity Ultrasound Combined with Levofloxacin-Loaded PLGA Nanoparticles on M. Smegmatis in Macrophages

2020 ◽  
Author(s):  
Shuang Xie ◽  
Gangjing Li ◽  
Yuru Hou ◽  
Min Yang ◽  
Fahui Li ◽  
...  
Keyword(s):  
Cell Structure ◽  
Low Frequency ◽  
Ultrasound Irradiation ◽  
Average Diameter ◽  
Bactericidal Effect ◽  
Plga Nanoparticles ◽  
Low Intensity ◽  
Low Intensity Ultrasound ◽  
Underlying Mechanisms

Abstract Purpose: Tuberculosis (TB) is a highly infectious disease caused by Mycobacterium tuberculosis (Mtb), which often parasites in macrophages. This study is performed to investigate the bactericidal effect and underlying mechanisms of low-frequency and low-intensity ultrasound (LFLIU) combined with levofloxacin-loaded PLGA nanoparticles (LEV-NPs) on M. smegmatis (a surrogate of Mtb) in macrophages.Methods and results: The LEV-NPs were prepared using a double emulsification method. The average diameter, zeta potential, polydispersity index, morphology, and drug release efficiency in vitro of the LEV-NPs were investigated. M. smegmatis in macrophages was treated using the LEV-NPs combined with 42 kHz ultrasound irradiation at an intensity of 0.13 W/cm2 for 10 min. The results showed that ultrasound significantly promoted the phagocytosis of nanoparticles by macrophages (p < 0.05). In addition, further ultrasound combined with the LEV-NPs promoted the production of reactive oxygen species (ROS) in macrophage , and the apoptosis rate of the macrophages was significantly higher than that of the control (p < 0.05). The transmission electronic microscope showed that the cell wall of M. smegmatis was ruptured, the cell structure was incomplete, and the bacteria received severe damage in the ultrasound combined with the LEV-NPs group. Activity assays showed that ultrasound combined with the LEV-NPs exhibited a 10-fold higher antibacterial activity against M. smegmatis residing inside macrophages compared with the free drug.Conclusion: These data demonstrated that ultrasound combined with LEV-NPs has great potential as a therapeutic agent for TB.

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