Synthesis of Symmetrical Dipurine-Nucleoside Diphosphates from the Corresponding Nucleoside Phosphoropiperidates
A general and efficient method for the preparation of symmetrical dinucleoside diphosphates with purine bases has been developed. Ap2A and Gp2G were synthesized from the in situ hydrolysis of corresponding nucleoside 5′-phosphoropiperidates with 4,5-dicyanoimidazole as the activator. This method features easily accessible starting materials, simple procedures, and good yield.
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2016 ◽
Vol 14
(2)
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pp. 556-563
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2014 ◽
Vol 662
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pp. 59-62
1975 ◽
Vol 64
(3)
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pp. 586-607
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2020 ◽