Preparation of Aspirin-β-Cyclodextrin Inclusion Complex by Grinding Method

2015 ◽  
Vol 1120-1121 ◽  
pp. 882-885 ◽  
Author(s):  
Xiang Qun Xu ◽  
Nian Hong ◽  
Jing Wen Zheng ◽  
Bing Bing Guo ◽  
Lin Cheng
Keyword(s):  
Orthogonal Experiment ◽  
Process Condition ◽  
Molar Ratio ◽  
Process Conditions ◽  
Inclusion Process ◽  
Grinding Method ◽  
Cyclodextrin Inclusion ◽  
Main Factors ◽  
Cyclodextrin Inclusion Complex ◽  
Time Of Reaction

To study the process conditions for preparing aspirin β-cyclodextrin inclusion.Method: Choose the usage ration of aspirin with β-cyclodextrin and the time of reaction as the main factors, and use the inclusion yield as evaluated indicators and the process condition to conduct orthogonal experiment Optimization Pack aspirin.Outcome: The optimum inclusion process condition: molar ratio of the aspirin with β-cyclodextrin is 1:3, inclusion time is 60 minutes.Conclusion: The process condition of using β-cyclodextrin inclusion to inconcluse aspirin is feasible, effective, and of applicative value.

Study on Preparation Technology Optimization of Sultamicillin Tosilate-β-Cyclodextrin

2015 ◽  
Vol 1120-1121 ◽  
pp. 873-876
Author(s):  
Xiang Qun Xu ◽  
Nian Hong ◽  
Jie Yang ◽  
You Quan Zhong ◽  
Lin Cheng
Keyword(s):  
Orthogonal Experiment ◽  
Process Condition ◽  
Molar Ratio ◽  
Process Conditions ◽  
Preparation Technology ◽  
Inclusion Process ◽  
Cyclodextrin Inclusion ◽  
Main Factors ◽  
Time Of Reaction

To study the process conditions for preparing sultamicillin tosilate β-cyclodextrin inclusion.Method: Choose the usage ration of sultamicillin tosilate with β-cyclodextrin, the inclusion temperature and the time of reaction as the main factors, and use the inclusion yield as evaluated indicators and the process condition to conduct the L9 (34) orthogonal experiment Optimization Pack sultamicillin tosilate.Outcome: The optimum inclusion process condition: molar ratio of the sultamicillin tosilate with β-cyclodextrin is 1:8, inclusion temperature is 47°C, inclusion time is 40 minutes.Conclusion: The process condition of using β-cyclodextrin inclusion to inconcluse sultamicillin tosilate is feasible, effective, and of applicative value.

Using Fly Ash to Preparare Polysilicate Aluminum Ferric Flocculant and Treating Coal Slurry

2015 ◽  
Vol 1092-1093 ◽  
pp. 966-971
Author(s):  
Jian Li Yang ◽  
Mei Li Du ◽  
Gang Li
Keyword(s):  
Fly Ash ◽  
Orthogonal Experiment ◽  
Curing Temperature ◽  
Molar Ratio ◽  
Optimum Process ◽  
Process Conditions ◽  
Coal Slurry ◽  
Element Ratio ◽  
Silicon Iron ◽  
Aluminum Iron

Solid waste resource utilization is a important way for sustainable economic development, environmental and ecological protection. Using adsorption and flocculation characteristics of fly ash to preparare fly ash-based inorganic flocculant and use it for treating slime water, make waste fly ash into treasure, not only solve environmental problems, but also has very important theoretical significance and application value.In this study, we use Na2CO3 melt to improve acid-soluble activity of fly ash, extract ideally the aluminum and iron silicon as active ingredients in the fly ash. On the basis of the solubilization experiment, we design orthogonal experiment about larger impact several factors on the the flocculant preparation of process: silicon and aluminum element ratio, silicon iron element ratio and curing temperature, the orthogonal experiment results show that the best optimum process conditions is: Si: Al (mole ratio) is 1:0.5, Si: Fe (molar ratio) is 1:0.5, curing temperature is 60°C, curing time is 2 hours. Finally, we use poly silicate aluminum iron flocculants prepared to do flocculation test on slime water, determine the best flocculation conditions is: when we treat slime water which concentration is 8g/L and volume is 250mL, the optimum dosage of polysilicate aluminum iron is 1.3mL, the transmittance gets to 74.2%, the flocculation effect is the best.

Effects of Process Conditions on Properties of Nano-Magnetic Fluid

2011 ◽  
Vol 194-196 ◽  
pp. 700-703
Author(s):  
Bing Chen ◽  
Yu Guang Fan
Keyword(s):  
Saturation Magnetization ◽  
Sodium Oleate ◽  
Magnetic Fluid ◽  
Magnetic Particles ◽  
Ph Value ◽  
Orthogonal Experiment ◽  
Process Condition ◽  
Nano Particles ◽  
Process Conditions ◽  
Co Precipitation

In order to analyze the influences of process condition on kerosene-based Fe3O4, which are prepared in chemical co-precipitation, orthogonal experiment was used. How process condition influenced the size of nano-particles and saturation magnetization was studied, and the best process condition as 40ml•min-1 NaOH adding speed, 10ml•min-1 sodium oleate adding speed, 45°C reaction temperature, 15min holding time and pH value of 2 of coating sodium oleate was obtained. The performance of magnetic particles was characterized by transmission electron microscopy (TEM) and WSM vibration magnetometer. The diameter of Fe3O4 nano-particles was less than 10nm, saturation magnetization was 2.66×104A•m-1, viscosity of nano-magnetic fluid was 18mPa•s, and density was 1.13×103kg•m-3. This research enhanced the foundation of using nano-magnetic fluid.

Optimization of Preparation Process of Essential Oil of Baokening Granule-β-Cyclodextrin Inclusion by Orthogonal Test

2014 ◽  
Vol 937 ◽  
pp. 118-121
Author(s):  
Fang Luo ◽  
Shun Bin Qiao
Keyword(s):  
Essential Oil ◽  
Orthogonal Design ◽  
Process Condition ◽  
Phase Method ◽  
Optimum Process ◽  
Process Conditions ◽  
Inclusion Process ◽  
Preparation Conditions ◽  
Liquid Phase Method ◽  
Inclusion Rate

To study optimum inclusion process conditions for essential oil from perilla and Pericarpium Citri Reticulatae in Baokening granule,the utilization ratio of volatile and the inclusion rate were determined to evaluate process conditions, and the condition was optimized with orthogonal design by the liquid-phase method in aqueous solution. The experiment results showed that the optimum preparation conditions for inclusion were established as: oil: ß-CD was 1:8, and ratio of amount of water to ß –CD was 10. The inclusion temperature and time were at 40°C and for 180 min. The yield is high in such optimum process condition and the inclusion effect is good.

scholarly journals Optimization of process conditions for catalytic alkylation of isomeric cresols with cyclohexene

2012 ◽  
Vol 47 (2) ◽  
pp. 153-160
Author(s):  
Mohammad Kamruzzaman ◽  
Ashequl Alam Rana ◽  
Manoranjan Saha
Keyword(s):  
Perchloric Acid ◽  
Molar Ratio ◽  
High Yield ◽  
Process Conditions ◽  
Reaction Parameters ◽  
Reaction Conditions ◽  
Optimum Yield ◽  
Catalytic Alkylation ◽  
Time Of Reaction

Alkylation of isomeric cresols with cyclohexene in presence of perchloric acid as catalyst was studied and cyclohexyl cresols obtained in high yield. The effects of the variation of reaction parameters such as temperature, molar ratio of cresol to cyclohexene, amount of perchloric acid and time of reaction were investigated. The yield of the products increased with the increase of each of the above-mentioned parameters. Optimum yield (97.6% for cyclohexyl m-cresol; 95.4% for 2-cyclohexyl-4-methylphenol and 91.2% for cyclohexyl o-cresol) of the products were obtained under the reaction conditions of a temperature of 140ºC; an 8-6:1 molar ratio of cresol to cyclohexene, a 5% by weight perchloric acid of cresol, a 2 h time of addition of cyclohexene and a 2 h time of stirring of the reaction mixture. Considering the yields of cyclohexyl cresols and ease of purifications, the above mentioned conditions were accounted as optimum for the alkylation of isomeric cresols with cyclohexene in the presence of perchloric acid.   DOI: http://dx.doi.org/10.3329/bjsir.v47i2.11446   Bangladesh J. Sci. Ind. Res. 47(2), 153-160, 2012  

scholarly journals Comprehensive Characterisation of the Ketoprofen-β-Cyclodextrin Inclusion Complex Using X-ray Techniques and NMR Spectroscopy

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4089
Author(s):  
Katarzyna Betlejewska-Kielak ◽  
Elżbieta Bednarek ◽  
Armand Budzianowski ◽  
Katarzyna Michalska ◽  
Jan K. Maurin
Keyword(s):  
Nmr Spectroscopy ◽  
Inclusion Complex ◽  
Crystal And Molecular Structure ◽  
Binding Constants ◽  
Nmr Studies ◽  
X Ray ◽  
Cyclodextrin Inclusion ◽  
Powder Samples ◽  
Cyclodextrin Inclusion Complex ◽  
Co Precipitation

Racemic ketoprofen (KP) and β-cyclodextrin (β-CD) powder samples from co-precipitation (1), evaporation (2), and heating-under-reflux (3) were analysed using X-ray techniques and nuclear magnetic resonance (NMR) spectroscopy. On the basis of NMR studies carried out in an aqueous solution, it was found that in the samples obtained by methods 1 and 2, there were large excesses of β-CD in relation to KP, 10 and 75 times, respectively, while the sample obtained by method 3 contained equimolar amounts of β-CD and KP. NMR results indicated that KP/β-CD inclusion complexes were formed and the estimated binding constants were approximately 2400 M−1, showing that KP is quite strongly associated with β-CD. On the other hand, the X-ray single-crystal technique in the solid state revealed that the (S)-KP/β-CD inclusion complex with a stoichiometry of 2:2 was obtained as a result of heating-under-reflux, for which the crystal and molecular structure were examined. Among the methods used for the preparation of the KP/β-CD complex, only method 3 is suitable.

scholarly journals Continuous Integrated Process of Biodiesel Production and Purification—The End of the Conventional Two-Stage Batch Process?

Energies ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 403
Author(s):  
Matea Bačić ◽  
Anabela Ljubić ◽  
Martin Gojun ◽  
Anita Šalić ◽  
Ana Jurinjak Tušek ◽  
...  
Keyword(s):  
Extraction Efficiency ◽  
Deep Eutectic Solvent ◽  
International Standards ◽  
Biodiesel Production ◽  
Molar Ratio ◽  
Process Conditions ◽  
Integrated Process ◽  
Free Glycerol ◽  
Mass Ratio ◽  
Glycerol Content

In this research, optimization of the integrated biodiesel production process composed of transesterification of edible sunflower oil, catalyzed by commercial lipase, with simultaneous extraction of glycerol from the reaction mixture was performed. Deep eutectic solvents (DESs) were used in this integrated process as the reaction and extraction media. For two systems, choline chloride:glycerol (ChCl:Gly) and choline chloride:ethylene glycol (ChCl:EG), respectively, the optimal water content, mass ratio of the phase containing the mixture of reactants (oil and methanol) with an enzyme and a DES phase (mass ratio of phases), and the molar ratio of deep eutectic solvent constituents were determined using response surface methodology (RSM). Experiments performed with ChCl:Gly resulted in a higher biodiesel yield and higher glycerol extraction efficiency, namely, a mass ratio of phases of 1:1, a mass fraction of water of 6.6%, and a molar ratio of the ChCl:Gly of 1:3.5 were determined to be the optimal process conditions. When the reaction was performed in a batch reactor under the optimal conditions, the process resulted in a 43.54 ± 0.2% yield and 99.54 ± 0.19% glycerol extraction efficiency (t = 2 h). Unfortunately, the free glycerol content was higher than the one defined by international standards (wG > 0.02%); therefore, the process was performed in a microsystem to enhance the mass transfer. Gaining the same yield and free glycerol content below the standards (wG = 0.0019 ± 0.003%), the microsystem proved to be a good direction for future process optimization.

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