Essential Factors to Make Excellent Biocompatibility of Phospholipid Polymer Materials

2010 ◽  
Vol 76 ◽  
pp. 1-9 ◽  
Author(s):  
Kazuhiko Ishihara ◽  
Yuuki Inoue
Keyword(s):  
Radical Polymerization ◽  
Blood Compatibility ◽  
Membrane Surface ◽  
Polymer Brush ◽  
Living Radical Polymerization ◽  
Polymer Chains ◽  
Polymer Materials ◽  
Biomaterial Surface ◽  
Phospholipid Polymer ◽  
Living Organisms

Recently, much attention has been attracted to bio/blood compatible materials to suppress undesirable biological reactions that determine the fate of living organisms and materials. A phospholipid polymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) unit, which is designed by inspiration of cell membrane surface structure, is the most promising polymer biomaterial with excellent bio/blood compatibility. Progress in living radical polymerization method initiated from the surface enables preparation of a dense polymer chains on the surface, which is called as a polymer brush. The polymer brush structure has narrow molecular weight distribution and controlled chain length. So, it is ideal surface to clarify the interactions between the biomolecules and biomaterial surface that has never done. In these regards, the poly(MPC) brush surfaces are expected to be a novel class of biomaterials, and have been extensively studied its unusual properties. In this review, surface-initiated living radical polymerization of MPC and the characteristics of the poly(MPC) brush surfaces are summarized from a viewpoint of biomaterials science.

scholarly journals Oil Deposition on Polymer Brush-Coated NF Membranes

Membranes ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 168 ◽  
Author(s):  
Anh Vu ◽  
Naama Segev Mark ◽  
Guy Z. Ramon ◽  
Xianghong Qian ◽  
Arijit Sengupta ◽  
...  
Keyword(s):  
Membrane Fouling ◽  
Membrane Surface ◽  
Polymer Brush ◽  
Operating Mode ◽  
Feed Solution ◽  
Polymer Chains ◽  
Membrane Properties ◽  
Solution Temperature ◽  
Oil Droplets ◽  
Grafted Polymer

Membrane-based processes are attractive for treating oily wastewaters. However, membrane fouling due to the deposition of oil droplets on the membrane surface compromises performance. Here, real-time observation of the deposition of oil droplets by direct confocal microscopy was conducted. Experiments were conducted in dead-end and crossflow modes. Base NF 270 nanofiltration membranes as well as membranes modified by grafting poly(N-isopropylacrylamide) chains from the membrane surface using atom transfer radical polymerization were investigated. By using feed streams containing low and high NaCl concentrations, the grafted polymer chains could be induced to switch conformation from a hydrated to a dehydrated state, as the lower critical solution temperature for the grafted polymer chains moved above and below the room temperature, respectively. For the modified membrane, it was shown that switching conformation of the grafted polymer chains led to the partial release of adsorbed oil. The results also indicate that, unlike particles such as polystyrene beads, adsorption of oil droplets can lead to coalescence of the adsorbed oil droplets on the membrane surface. The results provide further evidence of the importance of membrane properties, feed solution characteristics, and operating mode and conditions on membrane fouling.

Blood Clearance and Biodistribution of Polymer Brush-Afforded Silica Particles Prepared by Surface-Initiated Living Radical Polymerization

2012 ◽  
Vol 13 (3) ◽  
pp. 927-936 ◽  
Author(s):  
Kohji Ohno ◽  
Tatsuki Akashi ◽  
Yoshinobu Tsujii ◽  
Masaya Yamamoto ◽  
Yasuhiko Tabata
Keyword(s):  
Radical Polymerization ◽  
Polymer Brush ◽  
Silica Particles ◽  
Living Radical Polymerization ◽  
Blood Clearance

Fabrication of Complex Three-Dimensional Polymer Brush Nanostructures through Light-Mediated Living Radical Polymerization

2013 ◽  
Vol 52 (27) ◽  
pp. 6844-6848 ◽  
Author(s):  
Justin E. Poelma ◽  
Brett P. Fors ◽  
Gregory F. Meyers ◽  
John W. Kramer ◽  
Craig J. Hawker
Keyword(s):  
Radical Polymerization ◽  
Polymer Brush ◽  
Three Dimensional ◽  
Living Radical Polymerization

Fabrication of Complex Three-Dimensional Polymer Brush Nanostructures through Light-Mediated Living Radical Polymerization

2013 ◽  
Vol 125 (27) ◽  
pp. 6982-6986 ◽  
Author(s):  
Justin E. Poelma ◽  
Brett P. Fors ◽  
Gregory F. Meyers ◽  
John W. Kramer ◽  
Craig J. Hawker
Keyword(s):  
Radical Polymerization ◽  
Polymer Brush ◽  
Three Dimensional ◽  
Living Radical Polymerization

scholarly journals Constructing Functional Ionic Membrane Surface by Electrochemically Mediated Atom Transfer Radical Polymerization

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Fen Ran ◽  
Dan Li ◽  
Jiayu Wu
Keyword(s):  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Electric Potential ◽  
Active Sites ◽  
Blood Compatibility ◽  
Membrane Surface ◽  
Monomer Concentration ◽  
Sodium Acrylate ◽  
Atom Transfer ◽  
Polymerization Time

The sodium polyacrylate (PAANa) contained polyethersulfone membrane that was fabricated by preparation of PES-NH2via nonsolvent phase separation method, the introduction of bromine groups as active sites by graftingα-Bromoisobutyryl bromide, and surface-initiated electrochemically atom transfer radical polymerization (SI-eATRP) of sodium acrylate (AANa) on the surface of PES membrane. The polymerization could be controlled by reaction condition, such as monomer concentration, electric potential, polymerization time, and modifier concentration. The membrane surface was uniform when the monomer concentration was 0.9 mol/L, the electric potential was −0.12 V, the polymerization time was 8 h, and the modifier concentration was 2 wt.%. The membrane showed excellent hydrophilicity and blood compatibility. The water contact angle decreased from 84° to 68° and activated partial thromboplastin increased from 51 s to 84 s after modification of the membranes.

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