The Effect of Flux Dysconnectivity Functions on Concentration Gradients Changes in a Multicomponent Model of Convectional Reaction-Diffusion by the Example of a Neurovascular Unit

2021 ◽  
Vol 413 ◽  
pp. 19-28
Author(s):  
Yaroslav R. Nartsissov
Keyword(s):  
Blood Flow ◽  
Fluid Flow ◽  
Blood Vessels ◽  
High Speed ◽  
Neurovascular Unit ◽  
Reaction Diffusion ◽  
Navier Stokes ◽  
Concentration Gradients ◽  
Navier Stokes Equation ◽  
Specific Trait

A convectional diffusion of nutrients around the blood vessels in brain occurs in well-structured neurovascular units (NVU) including neurons, glia and micro vessels. A common feature of the process is a combination of a relatively high-speed delivery solution stream inside the blood vessel and a low-speed convectional flow in parenchyma. The specific trait of NVU is the existence of a tight cover layer around the vessels which is formed by shoots (end-feet) of astrocytes. This layer forms so called blood-brain barrier (BBB). Under different pathological states the permeability of BBB is changed. The concentration gradient of a chemical compound in NVU has been modelled using a combination of mathematical description of a cerebral blood flow (CBF) and further 3D diffusion away from the blood vessels borders. The governing equation for the blood flow is the non-steady-state Navier–Stokes equation for an incompressible non-Newtonian fluid flow without buoyancy effects. BBB is modeled by the flux dysconnectivity functions. The velocity of fluid flow in the paravascular space was estimated using Darcy's law. Finally, the diffusion of the nutrient is considered as a convectional reaction-diffusion in a porous media. By the example of glucose, it was shown that increased permeability of BBB yields an increased level of the nutrient even under essential (on 70%) decrease of CBF. Contrarily, a low BBB permeability breeds a decreased concentration level under increased (on 50%) CBF. Such a phenomenon is explained by a smooth enlarge of the direct diffusion area for a blood-to-brain border glucose transport having three-level organization.

scholarly journals COMPUTER MODELING OF STENT DEPLOYMENT AND PLAQUE PROGRESSION IN THE CORONARY ARTERIES

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Nenad Filipović ◽  
Velibor Isailović ◽  
Žarko Milosević ◽  
Dalibor Nikolić ◽  
Igor Saveljić ◽  
...  
Keyword(s):  
Blood Flow ◽  
Coronary Arteries ◽  
Mixed Finite Element ◽  
Flow Simulation ◽  
Reaction Diffusion ◽  
Navier Stokes ◽  
Stent Deployment ◽  
Specific Patient ◽  
Nonlinear Viscoelastic ◽  
Solute Dynamics

In this study stent deployment modeling with plaque formation and pro- gression for specific patient in the coronary arteries are described. State of the art method for the reported investigations of blood flow in the stented arteries is described. In the met- hod section, image segmentation method for arteries with stent is shortly described. Blood flow simulation is described with Navier-Stokes and continuity equation. Blood vessel tis- sue is modeled with nonlinear viscoelastic material properties. The coupling of fluid dynamics and solute dynamics at the endothelium was achieved by the Kedem-Katchalsky equations. The inflammatory process is modeled using three additional reaction-diffusion partial differential equations. Coupled method with mixed finite element and DPD (Dissi- pative Particle Dynamics) method is presented. In the results section, the examples with rigid and deformable arterial wall with stented and unstented arteries are presented. Effecti- ve stress analysis results for stent deployment have been shown. It can be seen that stent reduces wall shear stress significantly after deployment which is caused by opening the artery and reducing the narrowing. Some results for stent deployment model obtained with solver developed under PAK software package. These computer models can make better understanding and preparation of the surgeons for stent deployment in everyday clinical practice.

scholarly journals Physiologic blood flow is turbulent

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Khalid M. Saqr ◽  
Simon Tupin ◽  
Sherif Rashad ◽  
Toshiki Endo ◽  
Kuniyasu Niizuma ◽  
...  
Keyword(s):  
Blood Flow ◽  
Stokes Equation ◽  
Initial Conditions ◽  
Hydrodynamic Instability ◽  
Transition To Turbulence ◽  
Navier Stokes ◽  
Navier Stokes Equation ◽  
Frequency Spectra ◽  
Hydrodynamic Stability Theory

Abstract Contemporary paradigm of peripheral and intracranial vascular hemodynamics considers physiologic blood flow to be laminar. Transition to turbulence is considered as a driving factor for numerous diseases such as atherosclerosis, stenosis and aneurysm. Recently, turbulent flow patterns were detected in intracranial aneurysm at Reynolds number below 400 both in vitro and in silico. Blood flow is multiharmonic with considerable frequency spectra and its transition to turbulence cannot be characterized by the current transition theory of monoharmonic pulsatile flow. Thus, we decided to explore the origins of such long-standing assumption of physiologic blood flow laminarity. Here, we hypothesize that the inherited dynamics of blood flow in main arteries dictate the existence of turbulence in physiologic conditions. To illustrate our hypothesis, we have used methods and tools from chaos theory, hydrodynamic stability theory and fluid dynamics to explore the existence of turbulence in physiologic blood flow. Our investigation shows that blood flow, both as described by the Navier–Stokes equation and in vivo, exhibits three major characteristics of turbulence. Womersley’s exact solution of the Navier–Stokes equation has been used with the flow waveforms from HaeMod database, to offer reproducible evidence for our findings, as well as evidence from Doppler ultrasound measurements from healthy volunteers who are some of the authors. We evidently show that physiologic blood flow is: (1) sensitive to initial conditions, (2) in global hydrodynamic instability and (3) undergoes kinetic energy cascade of non-Kolmogorov type. We propose a novel modification of the theory of vascular hemodynamics that calls for rethinking the hemodynamic–biologic links that govern physiologic and pathologic processes.

Toward a Global Model for FSI in Tube Bundles

2008 ◽  
Author(s):  
Daniel Broc ◽  
Marion Duclercq
Keyword(s):  
Fluid Flow ◽  
Euler Equations ◽  
Dynamic Behaviour ◽  
Navier Stokes ◽  
Inertial Effects ◽  
Navier Stokes Equation ◽  
Dissipative Effects ◽  
Tube Bundles ◽  
Homogenization Methods ◽  
Physical Phenomena

It is well known that a fluid may strongly influence the dynamic behaviour of a structure. Many different physical phenomena may take place, depending on the conditions: fluid at rest, fluid flow, little or high displacements of the structure. Inertial effects can take place, with lower vibration frequencies, dissipative effects also, with damping, instabilities due to the fluid flow (Fluid Induced Vibration). In this last case the structure is excited by the fluid. The paper deals with the vibration of tube bundles in a fluid, under a seismic excitation or an impact. In this case the structure moves under an external excitation, and the movement is influenced by the fluid. The main point in such system is that the geometry is complex, and could lead to very huge sizes for a numerical analysis. Many works has been made in the last years to develop homogenization methods for the dynamic behaviour of tube bundles (/2/ and /3/). The size of the problem is reduced, and it is possible to make numerical simulations on wide tubes bundles with reasonable computer times. These homogenization methods are valid for “little displacements” of the structure (the tubes), in a fluid at rest. The fluid movement is governed by the Euler equations. In this case, only “inertial effects” will take place, with globally lower frequencies. It is well known that dissipative effects due to the fluid may take place, even if the displacements of the tube are no so high, or if the fluid is not still (/4/, /5/, /6/ and /8/). Such effects may be described in the homogenized models by using a Rayleigh damping, but the basic assumption of the model remains the “perfect fluid” hypothesis. It seem necessary, in order to get a best description of the physical phenomena, to build a more general model, based on the general Navier Stokes equation for the fluid. The homogenization of such system will be much more complex than for the Euler equations. The paper doesn’t pretend to give a general solution of the problem, but only points out the most important key points to build such homogenized model for the dynamic behaviour of tubes bundles in a fluid.

Human Aorta Buckling Related to Dissection

2010 ◽  
Author(s):  
Kostas Karagiozis ◽  
Marco Amabili ◽  
Rosaire Mongrain ◽  
Raymond Cartier ◽  
Michael P. Pai¨doussis
Keyword(s):  
Blood Flow ◽  
Nonlinear Stability ◽  
Shell Theory ◽  
Inviscid Flow ◽  
Mechanical Stresses ◽  
Surrounding Tissue ◽  
Navier Stokes ◽  
Human Aorta ◽  
Navier Stokes Equation ◽  
Viscous Stresses

Human aortas are subjected to large mechanical stresses and loads due to blood flow pressurization and through contact with the surrounding tissue and muscle. It is essential that the aorta does not lose stability for proper functioning. The present work investigates the buckling of human aorta relating it to dissection by means of an analytical model. A full bifurcation analysis is used employing a nonlinear model to investigate the nonlinear stability of the aorta conveying blood flow. The artery is modeled as a shell by means of Donnell’s nonlinear shell theory retaining in-plane inertia, while the fluid is modelled by a Newtonian inviscid flow theory but taking into account viscous stresses via the time-averaged Navier-Stokes equation. The three shell displacements are expanded using trigonometric series that satisfy the boundary conditions exactly. A parametric study is undertaken to determine the effect of aorta length, thickness, Young’s modulus, and transmural pressure on the nonlinear stability of the aorta. As a first attempt to study dissection, a quasi-steady approach is taken, in which the flow is not pulsatile but steady. The effect of increasing flow velocity is studied, particularly where the system loses stability, exhibiting static collapse. Regions of large mechanical stresses on the artery surface are identified for collapsed arteries indicating possible ways for dissection to be initiated.

scholarly journals A laboratory exercise using a physical model for demonstrating countercurrent heat exchange

2012 ◽  
Vol 36 (1) ◽  
pp. 58-62
Author(s):  
Catherine Loudon ◽  
Elizabeth C. Davis-Berg ◽  
Jason T. Botz
Keyword(s):  
Blood Flow ◽  
Heat Exchange ◽  
Blood Vessels ◽  
Physical Model ◽  
Circulatory System ◽  
Concentration Gradients ◽  
Laboratory Exercise ◽  
Permeable Barrier ◽  
Countercurrent Exchange ◽  
Physical Principles

A physical model was used in a laboratory exercise to teach students about countercurrent exchange mechanisms. Countercurrent exchange is the transport of heat or chemicals between fluids moving in opposite directions separated by a permeable barrier (such as blood within adjacent blood vessels flowing in opposite directions). Greater exchange of heat or chemicals between the fluids occurs when the flows are in opposite directions (countercurrent) than in the same direction (concurrent). When a vessel loops back on itself, countercurrent exchange can occur between the two arms of the loop, minimizing loss or uptake at the bend of the loop. Comprehension of the physical principles underlying countercurrent exchange helps students to understand how kidneys work and how modifications of a circulatory system can influence the movement of heat or chemicals to promote or minimize exchange and reinforces the concept that heat and chemicals move down their temperature or concentration gradients, respectively. One example of a well-documented countercurrent exchanger is the close arrangement of veins and arteries inside bird legs; therefore, the setup was arranged to mimic blood vessels inside a bird leg, using water flowing inside tubing as a physical proxy for blood flow within blood vessels.

scholarly journals Effects of Stenting on Blood Flow in a Coronary Artery Network Model

2006 ◽  
Vol 3 (2) ◽  
pp. 77-86
Author(s):  
R. Raghu ◽  
A. Pullan ◽  
N. Smith
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Finite Difference Method ◽  
Vessel Wall ◽  
Flow Patterns ◽  
Navier Stokes ◽  
Pressure Gradients ◽  
Computationally Efficient ◽  
Navier Stokes Equation ◽  
Local Flow

The effect of stenting on blood flow is investigated using a model of the coronary artery network. The parameters in a generic non-linear pressure–radius relationship are varied in the stented region to model the increase in stiffness of the vessel due to the presence of the stent. A computationally efficient form of the Navier–Stokes equation is solved using a Lax–Wendroff finite difference method. Pressure, vessel radius and flow velocity are computed along the vessel segments. Results show negative pressure gradients at the ends of the stent and increased velocity through the middle of the stented region. Changes in local flow patterns and vessel wall stresses due to the presence of the stent have been shown to be important in restenosis of vessels. Local and global pressure gradients affect local flow patterns and vessel wall stresses, and therefore may be an important factor associated with restenosis. The model presented in this study can be easily extended to solve flows for stented vessels in a full, anatomically realistic coronary network. The framework to allow for the effects of the deformation of the myocardium on the coronary network is also in place.

scholarly journals Mathematical modelling of fluid flow in electromagnetically stirred weld pool

2021 ◽  
Vol 1201 (1) ◽  
pp. 012025
Author(s):  
K Enger ◽  
M G Mousavi ◽  
A Safari
Keyword(s):  
Fluid Flow ◽  
Grain Refinement ◽  
Weld Pool ◽  
Fluid Velocity ◽  
Navier Stokes ◽  
Navier Stokes Equation ◽  
Turbulent Fluid Flow ◽  
Flow Modelling ◽  
Weld Parameters ◽  
The Relationship

Abstract In this paper, a mathematical model has been proposed to study the relationship between electromagnetic stirring (EMS) weld parameters and the mode of fluid flow on grain refinement of AA 6060 weldments. For this purpose, fluid flow modelling using Navier-Stokes equation is described first, and then, the proposed mathematical approach has been discussed in detail. For demonstration, calculations to determine the fluid velocity in the weld pool of thin plate AA6060 were performed. The application of the model on the experimental results indicates that the best grain refinement is achieved at a transition mode from laminar to turbulent fluid flow.

scholarly journals Thermo-Elastohydrodynamic Study on Textured Journal Bearing with High-Speed and High-Specific-Pressure

2019 ◽  
Vol 37 (4) ◽  
pp. 751-756 ◽  
Author(s):  
Lin Wang ◽  
Yu Zhang ◽  
Guoding Chen
Keyword(s):  
Elastic Deformation ◽  
High Speed ◽  
Journal Bearing ◽  
Hydrodynamic Performance ◽  
Navier Stokes ◽  
Specific Pressure ◽  
Analysis Model ◽  
Navier Stokes Equation ◽  
Gear Transmission System ◽  
Load Carrying

The performance of supporting journal bearing of the star gear transmission system in the geared turbo fan engine (GTF) is analyzed. A thermal-elastohydrodynamic analysis model was developed for textured journal bearing used in high-speed and high-specific-pressure conditions. The Navier-Stokes equation, energy equation, and viscosity-temperature equation were calculated by the computational fluid dynamics method. The influence of elastic deformation on bearing thermal hydrodynamic performance was studied in detail. The results indicate that the elastic deformation has an influence on the distribution of oil temperature and oil pressure. Besides, a comparative thermo-elastohydrodynamic analysis was conducted between the textured bearing and the un-textured bearing, and the discrepancies of maximum oil pressure, load carrying capacity and the maximum oil temperature are few. However, the textured bearing has a lower elastic deformation than the un-textured bearing.

scholarly journals SIMULATION OF HYDRO-MECHANICAL PROCESSES IN CENTRIFUGAL PUMPS

2016 ◽  
Vol 2016 (1) ◽  
pp. 100-105
Author(s):  
Ризван Шахбанов ◽  
Rizvan Shakhbanov ◽  
Леонид Савин ◽  
Leonid Savin
Keyword(s):  
Fluid Flow ◽  
Continuity Equation ◽  
Equation Of Motion ◽  
Theoretical Description ◽  
Navier Stokes ◽  
Centrifugal Pumps ◽  
Navier Stokes Equation ◽  
Rotary Pumps ◽  
Rotating Coordinates ◽  
Graphical Presentation

The peculiarities in current and kinematics of hydromechanical processes in centrifugal (rotary) pumps are considered. The theoretical description and graphical presentation of velocity profiles in an impeller are shown. A complex current in an impeller is described with the aid of a continuity equation and Navier-Stokes equation for rotating coordinates. A nonviscous character of fluid flow in the setting of an im-peller is taken into account by means of averaging of the equation of motion for that purpose the equation of a turbulence model is introduced in addition. The scheme of the digitization of a modeling area with the aid of a volumetric endelement grid is presented. As an example a computer model as a part of an impeller is shown.

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