Apatite-Forming Ability of Glass-Ceramics Containing Whitlockite and Diopside in a Simulated Body Fluid

2006 ◽  
Vol 309-311 ◽  
pp. 341-344
Author(s):  
Masanobu Kamitakahara ◽  
Chikara Ohtsuki ◽  
Yuko Kozaka ◽  
Masao Tanihara ◽  
Toshiki Miyazaki
Keyword(s):  
Simulated Body Fluid ◽  
Mechanical Strength ◽  
Direct Contact ◽  
Body Fluid ◽  
Glass Composition ◽  
Glass Ceramics ◽  
Biodegradable Material ◽  
High Mechanical Strength ◽  
Prepared Glass ◽  
Bone Repairing

Tricalcium phosphate (3CaO⋅P2O5, TCP) is known as a biodegradable material and already used clinically as important bone-repairing materials. However, the control of its bone-bonding ability, i.e. bioactivity, and biodegradability is not easy. On the other hand, diopside (CaO⋅MgO⋅2SiO2) ceramic shows a potential of direct contact with bone and high mechanical strength, but low biodegradability. We expected that a glass-ceramic containing TCP and diopside show high bioactivity and high mechanical strength, as well as biodegradability. Glasses with composition x(3CaO⋅P2O5)⋅(100-x) (CaO⋅MgO⋅2SiO2) (x = 0, 38, 50, 60 mass%) were prepared. They were pulverized and the compacts of the resultant powders were heated to obtain the glass-ceramics. Only diopside was precipitated at x = 0 in the glass composition, whitlockite (β-TCP) and diopside were at x = 38, 50 and 60, when the compacts were sintered at 1200 °C. The prepared glass-ceramics formed apatite on their surfaces in a simulated body fluid (SBF). This indicates that these glass-ceramics have a potential to show bioactivity.

Surface Modification of Bio-Active Ceramic (Artificial Bone) by Ion Implantation

1991 ◽  
Vol 252 ◽  
Author(s):  
G. H. Takaoka ◽  
R. Tanaka ◽  
H. Usui ◽  
S. K. Koh ◽  
M. I. Current ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Ion Implantation ◽  
Mechanical Strength ◽  
Body Fluid ◽  
Glass Ceramics ◽  
Chemical Bonds ◽  
Artificial Bone ◽  
High Mechanical Strength ◽  
Living Bone ◽  
Bio Compatibility

ABSTRACTGlass-ceramics (A-W) containing apatite and wollastonite phases have been developed that show good bio-compatibility and rapidly form chemical bonds with living bone. The glass-ceramic (A-W) was implanted with 200 keV Zr and Ar ions at doses of 1E15 to 1E17 ions/sq.cm. It was found that the Zr ion implantation was effective for obtaining high mechanical strength in simulated body fluid. The increase of the mechanical strength can be considered to be due to the formation of Zr and O bonds by ion implantation. The bioactivity of the implanted ceramics remained, and was improved after soaking in the simulated body fluid. In the case of Ar ion implantation, the fracture strength was not improved. However, the bioactivity was strong and improved with increase of the time soaked in the simulated body fluid.

scholarly journals In Vitro Evaluation of Some Types of Ferrimagnetic Glass Ceramics

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
S. A. M. Abdel-Hameed ◽  
M. A. Marzouk ◽  
R. L. Elwan
Keyword(s):  
Simulated Body Fluid ◽  
Metal Oxides ◽  
Body Fluid ◽  
Simulated Body Fluid Solution ◽  
Glass Ceramics ◽  
Ion Extraction ◽  
Prepared Glass ◽  
Different Types ◽  
Icp Analysis

The present study aimed at studying the acceleration of the bioactive layer on the surface of ferrimagnetic glass ceramic with a basic composition 40Fe2O3–15P2O5–20SiO2–5TiO2through the addition of 20% of different types of metal oxides like MgO or CaO or MnO or CuO or ZnO or CeO2. SEM, EDAX, and ICP were applied to present the results of the study. SEM and EDAX measurements indicated the presence of apatite layer formed on the surface of the prepared glass ceramics after immersion in SBF within 7 to 30 days. The investigation of the results clarified that the addition of CaO or ZnO accelerated the formation of apatite on the surfaces of the samples in the simulated body fluid faster than other metal oxides. Inductive coupled plasma (ICP) analysis shows the evolution of ion extraction by the simulated body fluid solution (SBF) with time in relation to the elemental composition.

Development of Novel Mesoporous Silica-Based Bioactive Glass Scaffolds with Drug Delivery Capabilities

2014 ◽  
Vol 96 ◽  
pp. 54-60 ◽  
Author(s):  
Anahí Philippart ◽  
Elena Boccardi ◽  
Lucia Pontiroli ◽  
Ana Maria Beltrán ◽  
Alexandra Inayat ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Simulated Body Fluid ◽  
Mesoporous Silica ◽  
Body Fluid ◽  
Glass Composition ◽  
Glass Structure ◽  
Sol Gel ◽  
Bioactive Glasses

Novel silica-based bioactive glasses were successfully prepared by the sol-gel method. The optimized glass composition for fabrication of the scaffolds was (in mol.%) 60% SiO2 – 30% CaO - 5% Na2O - 5% P2O5 (60S30C5N5P). This composition was confirmed to develop a thick hydroxycarbonate apatite (HCA) layer in Simulated Body Fluid (SBF) after 7 days, as revealed by Fourier Transform Infrared Spectroscopy (FTIR), indicating the bioactive character of the scaffolds. The mesoporous nature of the glass structure allows the load of tetracycline and a sustained release of the drug in PBS during 7 days was measured.

scholarly journals Bonding between Bioactive Glasses, Glass-Ceramics or Ceramics in a Simulated Body Fluid

1987 ◽  
Vol 95 (1104) ◽  
pp. 785-791 ◽  
Author(s):  
Takashi KOKUBO ◽  
Tetsuya HAYASHI ◽  
Sumio SAKKA ◽  
Toshiaki KITSUGI ◽  
Takashi YAMAMURO
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Glass Ceramics ◽  
Bioactive Glasses

Microstructural analysis and bioactive response of selectively engineered glass-ceramics in simulated body fluid

2020 ◽  
pp. 1-9
Author(s):  
Abhijit Vyas ◽  
Vijay Shankar Kumawat ◽  
Subrata Bandhu Ghosh ◽  
Sanchita Bandyopadhyay-Ghosh
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Microstructural Analysis ◽  
Glass Ceramics

Prediction of osteoconductive activity of modified potassium fluorrichterite glass-ceramics by immersion in simulated body fluid

2010 ◽  
Vol 21 (11) ◽  
pp. 2979-2988 ◽  
Author(s):  
Shashwat Bhakta ◽  
Deepak K. Pattanayak ◽  
Hiroaki Takadama ◽  
Tadashi Kokubo ◽  
Cheryl A. Miller ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Glass Ceramics

BIOACTIVITY OF APATITE–WOLLASTONITE GLASS-CERAMICS PRODUCED BY MELTING CASTING

2013 ◽  
Vol 20 (01) ◽  
pp. 1350010 ◽  
Author(s):  
JONGEE PARK ◽  
ABDULLAH OZTURK
Keyword(s):  
Free Surface ◽  
Simulated Body Fluid ◽  
Glass Ceramic ◽  
Body Fluid ◽  
Glass Ceramics ◽  
Casting Process ◽  
Apatite Layer ◽  
Glassy Matrix ◽  
Apatite Formation ◽  
Ceramic Process

Glass-ceramics containing only apatite and wollastonite crystals were produced in the system MgO-CaO-SiO2-P2O5-F by the melt casting process. The bioactivity of the glass-ceramics was determined by immersing the glass-ceramics in a simulated body fluid (SBF) and by assessing the resulting apatite formation on the free surface after various immersion durations. A 12-μm-thick apatite layer formed on the surface of the glass-ceramic containing only apatite crystals after 20 days immersion in SBF. However, the thickness of the apatite layer formed on the surface of the glass-ceramic containing apatite and wollastonite crystals was 1 μm. Results have shown that the bioactivity of glass-ceramic depends strongly on the type of crystal(s) developed during the glass-ceramic process and their proportion in the glassy matrix.

scholarly journals Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions

Materials ◽  
2021 ◽  
Vol 14 (17) ◽  
pp. 4834
Author(s):  
Laura Aalto-Setälä ◽  
Peter Uppstu ◽  
Polina Sinitsyna ◽  
Nina C. Lindfors ◽  
Leena Hupa
Keyword(s):  
Phase Composition ◽  
Simulated Body Fluid ◽  
Bioactive Glass ◽  
Surgical Procedures ◽  
Continuous Flow ◽  
Body Fluid ◽  
Glass Composition ◽  
Ion Release ◽  
High Tendency

The silicate-based bioactive glass S53P4 is clinically used in bone regenerative applications in granule form. However, utilization of the glass in scaffold form has been limited by the high tendency of the glass to crystallize during sintering. Here, careful optimization of sintering parameters enabled the manufacture of porous amorphous S53P4 scaffolds with a strength high enough for surgical procedures in bone applications (5 MPa). Sintering was conducted in a laboratory furnace for times ranging from 25 to 300 min at 630 °C, i.e., narrowly below the commencement of the crystallization. The phase composition of the scaffolds was verified with XRD, and the ion release was tested in vitro and compared with granules in continuous flow of Tris buffer and simulated body fluid (SBF). The amorphous, porous S53P4 scaffolds present the possibility of using the glass composition in a wider range of applications.

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