Development of Novel Mesoporous Silica-Based Bioactive Glass Scaffolds with Drug Delivery Capabilities
2014 ◽
Vol 96
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pp. 54-60
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Keyword(s):
Sol Gel
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Novel silica-based bioactive glasses were successfully prepared by the sol-gel method. The optimized glass composition for fabrication of the scaffolds was (in mol.%) 60% SiO2 – 30% CaO - 5% Na2O - 5% P2O5 (60S30C5N5P). This composition was confirmed to develop a thick hydroxycarbonate apatite (HCA) layer in Simulated Body Fluid (SBF) after 7 days, as revealed by Fourier Transform Infrared Spectroscopy (FTIR), indicating the bioactive character of the scaffolds. The mesoporous nature of the glass structure allows the load of tetracycline and a sustained release of the drug in PBS during 7 days was measured.
Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system
2019 ◽
Vol 10
(2)
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pp. 455-470
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2012 ◽
Vol 476-478
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pp. 2059-2062
2017 ◽
Vol 160
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pp. 406-415
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