Polylactic Acid Scaffold Fabricated by Combination of Solvent Casting and Salt Leaching Techniques: Influence of β-Tricalcium Phosphate Contents

2017 ◽  
Vol 264 ◽  
pp. 42-45
Author(s):  
Rosaniza Md Isa ◽  
Mariatti Jaafar
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polylactic Acid ◽  
Tricalcium Phosphate ◽  
Three Dimensional ◽  
Combination Method ◽  
Solvent Casting ◽  
Salt Leaching

β-tricalcium phosphate (β-TCP) is a ceramic that commonly been used in bone tissue engineering. This material exhibits low mechanical properties such as low fracture toughness and brittleness. To overcome these problems, polylactic acid (PLA)/ β-TCP scaffolds for bone tissue engineering were prepared by using the combination method of solvent casting and salt leaching. These methods were used to produce three-dimensionally interconnected pores of the scaffold according to different ratio of β-TCP with porogen agent (sodium chloride (NaCl)). It is found that porosity and pore size of the scaffolds were independently controlled by the ratio and the particle size of the added porogen. The increases of pore interconnectivity were observed with increasing of PLA/ β-TCP/ NaCl ratios. Scaffolds with 80-90 wt% of total porogen content displayed acceptable mechanical properties for bone tissue engineering applications. Morphology observed by scanning electron microscopy (SEM) revealed that highly porous three-dimensional scaffold (>80 wt%) with well interconnected porous structure could be achieved by this combination process.

scholarly journals Microstructure design and degradation performance in vitro of three-dimensional printed bioscaffold for bone tissue engineering

2019 ◽  
Vol 11 (10) ◽  
pp. 168781401988378 ◽  
Author(s):  
Hongyu Jin ◽  
Yue Zhuo ◽  
Yang Sun ◽  
Hongya Fu ◽  
Zhenyu Han
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polylactic Acid ◽  
Tricalcium Phosphate ◽  
Three Dimensional ◽  
Spherical Pore ◽  
And Topology

In bone tissue engineering, three-dimensional printed biological scaffolds play an important role in the development of bone regeneration. The ideal scaffolds should have the ability to match the bone degradation rate and osteogenic ability. This article optimizes the unit cell model of the microstructure including spherical pore, gyroid, and topology to explore degradation performance of scaffolds. Boolean operation of array microstructure unit cells and selected part of a computer-aided design (CAD) femur model are adopted to create a reconstructed scaffold model. Polylactic acid/[Formula: see text]-tricalcium phosphate/hydroxyapatite scaffolds with spherical pore, gyroid, and topology-optimized structures are manufactured by three-dimensional printing utilizing the composition of bio-ink including polylactic acid, [Formula: see text]-tricalcium phosphate, and hydroxyapatite. After degradation of the scaffolds in vitro for several days, the mechanical properties are analyzed to study the effects of different microstructures on the degradation properties. The results show that the gyroid scaffolds with favorable degradability still maintain excellent mechanical properties after degradation. Mechanical properties of the scaffolds with topology-optimized structure and spherical pore microstructure scaffolds have a significant decrease after degradation.

scholarly journals In Vitro and In Vivo Characterization of N-Acetyl-L-Cysteine Loaded Beta-Tricalcium Phosphate Scaffolds

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Yong-Seok Jang ◽  
Phonelavanh Manivong ◽  
Yu-Kyoung Kim ◽  
Kyung-Seon Kim ◽  
Sook-Jeong Lee ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Water Soluble ◽  
Tetrazolium Salt ◽  
Porous Scaffolds ◽  
Tissue Engineering Application ◽  
Beta Tricalcium Phosphate

Beta-tricalcium phosphate bioceramics are widely used as bone replacement scaffolds in bone tissue engineering. The purpose of this study is to develop beta-tricalcium phosphate scaffold with the optimum mechanical properties and porosity and to identify the effect of N-acetyl-L-cysteine loaded to beta-tricalcium phosphate scaffold on the enhancement of biocompatibility. The various interconnected porous scaffolds were fabricated using slurries containing various concentrations of beta-tricalcium phosphate and different coating times by replica method using polyurethane foam as a passing material. It was confirmed that the scaffold of 40 w/v% beta-tricalcium phosphate with three coating times had optimum microstructure and mechanical properties for bone tissue engineering application. The various concentration of N-acetyl-L-cysteine was loaded on 40 w/v% beta-tricalcium phosphate scaffold. Scaffold group loaded 5 mM N-acetyl-L-cysteine showed the best viability of MC3T3-E1 preosteoblastic cells in the water-soluble tetrazolium salt assay test.

Poly(lactic-co-glycolic)/Nanostructured Merwinite Porous Composites for Bone Tissue Engineering. I. Preparation and Morphology

2011 ◽  
Vol 493-494 ◽  
pp. 718-722 ◽  
Author(s):  
Masoud Hafezi-Ardakani ◽  
Faranak Kavian ◽  
Fatollah Moztarzadeh ◽  
Mohamadreza Baghaban Eslaminejad ◽  
Ali Zamanian ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Weight Loss ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Solvent Casting ◽  
Salt Leaching ◽  
Uniform Microstructure ◽  
Porous Composites ◽  
Phosphate Buffered Saline ◽  
Interconnected Pores

A novel merwinite/ Poly(lactic-co-glycolic) nanocomposite was synthesized by a solvent casting/salt leaching technique with varying merwinite contents from 10 to 30% (w/w). Poly(lactic-co-glycolic) /merwinite foams with a co-continuous structure of interconnected pores were formed. The microstructure of the pores and the walls was controlled by varying the merwinite content. The pore structure becomes more and more irregular with increasing merwinite content. Pore sizes ranging from several microns to a few hundred microns were obtained. The degradation assessment of the scaffolds is performed in phosphate-buffered saline (PBS) solution at 37°C. Weight loss during storage at 37°C in PBS (pH 7.4) was determined for the scaffolds. Weight loss increased from pure to high content during incubation time. The prepared merwinite/ (Polylactic-co-glycolic) nanocomposite with uniform microstructure may be used in bone tissue engineering applications.

Fabrication of a chitosan/bioglass three-dimensional porous scaffold for bone tissue engineering applications

2014 ◽  
Vol 2 (38) ◽  
pp. 6611-6618 ◽  
Author(s):  
Jun Yang ◽  
Teng Long ◽  
Nan-Fei He ◽  
Ya-Ping Guo ◽  
Zhen-An Zhu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Porous Scaffold ◽  
Three Dimensional ◽  
Bone Defects ◽  
Engineering Applications

A chitosan/bioglass three-dimensional porous scaffold with excellent biocompatibility and mechanical properties has been developed for the treatment of bone defects.

Preparation and characterisation of a novel polylactic acid/hydroxyapatite/graphene oxide/aspirin drug-loaded biomimetic composite scaffold

2021 ◽  
Author(s):  
Shuqiong Liu ◽  
Wu Xiaoyan ◽  
Jiapeng Hu ◽  
Zhenzeng Wu ◽  
Yuying Zheng
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polylactic Acid ◽  
Composite Scaffold ◽  
Three Dimensional ◽  
Composite Scaffolds ◽  
Biomimetic Scaffolds

Biomimetic scaffolds loaded with drugs can be applied in bone tissue engineering. In this study, a series of three-dimensional polylactic acid/hydroxyapatite/graphene oxide (PLA/HA/GO) drug-loaded biomimetic composite scaffolds with different concentrations...

scholarly journals Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering

2010 ◽  
Vol 95A (3) ◽  
pp. 717-726 ◽  
Author(s):  
Laura Yanoso-Scholl ◽  
Justin A. Jacobson ◽  
Gino Bradica ◽  
Amy L. Lerner ◽  
Regis J. O'Keefe ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polylactic Acid ◽  
Tricalcium Phosphate ◽  
Beta Tricalcium Phosphate
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