scholarly journals A Mouse Model of Airway Disease: Oncostatin M-Induced Pulmonary Eosinophilia, Goblet Cell Hyperplasia, and Airway Hyperresponsiveness Are STAT6 Dependent, and Interstitial Pulmonary Fibrosis Is STAT6 Independent

2010 ◽  
Vol 186 (2) ◽  
pp. 1107-1118 ◽  
Author(s):  
Dominik K. Fritz ◽  
Christine Kerr ◽  
Ramzi Fattouh ◽  
Alba Llop-Guevara ◽  
Waliul I. Khan ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Mouse Model ◽  
Goblet Cell ◽  
Airway Hyperresponsiveness ◽  
Airway Disease ◽  
Oncostatin M ◽  
Pulmonary Eosinophilia ◽  
Cell Hyperplasia ◽  
Goblet Cell Hyperplasia ◽  
Interstitial Pulmonary Fibrosis

scholarly journals TGF-β Signaling May Play a Role in the Development of Goblet Cell Hyperplasia in a Mouse Model of Allergic Rhinitis

2010 ◽  
Vol 59 (3) ◽  
pp. 313-319 ◽  
Author(s):  
Yuhui Ouyang ◽  
Masanori Miyata ◽  
Kyosuke Hatsushika ◽  
Yuko Ohnuma ◽  
Ryohei Katoh ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
Goblet Cell ◽  
Cell Hyperplasia ◽  
Goblet Cell Hyperplasia

scholarly journals Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?

2010 ◽  
Vol 156 (6) ◽  
pp. 335-349 ◽  
Author(s):  
Amir A. Zeki ◽  
Jennifer M. Bratt ◽  
Michelle Rabowsky ◽  
Jerold A. Last ◽  
Nicholas J. Kenyon
Keyword(s):  
Mouse Model ◽  
Allergic Asthma ◽  
Goblet Cell ◽  
Airway Remodeling ◽  
Cell Hyperplasia ◽  
Goblet Cell Hyperplasia ◽  
Novel Treatment

MicroRNA let-7a up-regulates OPN expression in a mouse model of allergic rhinitis

2017 ◽  
Vol 131 (11) ◽  
pp. 955-960 ◽  
Author(s):  
H Yu ◽  
H Sun ◽  
Z Wang ◽  
Y Liu
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
Nasal Mucosa ◽  
Goblet Cell ◽  
Lavage Fluid ◽  
Interferon Γ ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cell Hyperplasia ◽  
Goblet Cell Hyperplasia ◽  
Significant Difference

AbstractObjective:To investigate the effect of microRNA let-7a on OPN expression in a mouse model of allergic rhinitis.Methods:Thirty-two mature female C57BL/6 mice were randomly divided into four groups, with eight mice in each group: microRNA let-7a, microRNA control, OVA and phosphate-buffered saline groups. The microRNA let-7a, microRNA control and OVA groups were sensitised with OVA to establish a mouse model of allergic rhinitis. Nose-scratching events were counted. Nasal mucosa was used to evaluate histological changes of goblet cell hyperplasia. Interleukins 5 and 13 were detected. Interferon-γ levels in the nasal lavage fluid were assayed with enzyme-linked immunosorbent assay. OPN expression was estimated with polymerase chain reaction.Results:Compared with microRNA control mice, microRNA let-7a treated mice had a significantly increased number of nose-scratching events, nasal mucosal eosinophilia and goblet cell hyperplasia (p < 0.05), and significantly higher interleukins 5 and 13 in nasal mucosa (p < 0.05), but there was no significant difference in interferon-γ (p > 0.05). In addition, microRNA let-7a treated mice had significantly enhanced OPN expression in nasal mucosa (p < 0.05).Conclusion:MicroRNA let-7a can promote allergic rhinitis development partly by regulating OPN expression.

scholarly journals The development of an in vitro 3D model of goblet cell hyperplasia using MUC5AC expression and repeated whole aerosol exposures

2021 ◽  
Author(s):  
Linsey E. Haswell ◽  
David Smart ◽  
Tomasz Jaunky ◽  
Andrew Baxter ◽  
Simone Santopietro ◽  
...  
Keyword(s):  
Goblet Cell ◽  
3D Model ◽  
Cell Hyperplasia ◽  
Goblet Cell Hyperplasia
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