The Role of the Mitochondrial Genome in Ageing and Carcinogenesis

Mitochondrial DNA mutations and polymorphisms have been the focus of intensive investigations for well over a decade in an attempt to understand how they affect fundamental processes such as cancer and aging. Initial interest in mutations occurring in mitochondrial DNA of cancer cells diminished when most were found to be the same mutations which occurred during the evolution of human mitochondrial haplogroups. However, increasingly correlations are being found between various mitochondrial haplogroups and susceptibility to cancer or diseases in some cases and successful aging in others.

Evolving insight into the role of mitochondrial DNA mutations in aging

Experimental Gerontology ◽

10.1016/j.exger.2007.09.010 ◽

2008 ◽

Vol 43 (1) ◽

pp. 20-23 ◽

Cited By ~ 6

Author(s):

G KUJOTH

Keyword(s):

Mitochondrial Dna ◽

Dna Mutations ◽

Insight Into

The role of control region mitochondrial DNA mutations in cardiovascular disease: stroke and myocardial infarction

Scientific Reports ◽

10.1038/s41598-020-59631-x ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 2

Author(s):

Miriam Umbria ◽

Amanda Ramos ◽

Maria Pilar Aluja ◽

Cristina Santos

Keyword(s):

Myocardial Infarction ◽

Cardiovascular Disease ◽

Mitochondrial Dna ◽

Control Region ◽

From sideroblastic anemia to the role of mitochondrial DNA mutations in myelodysplastic syndromes

Leukemia Research ◽

10.1016/s0145-2126(99)00160-5 ◽

2000 ◽

Vol 24 (2) ◽

pp. 141-151 ◽

Cited By ~ 80

Author(s):

Norbert Gattermann

Keyword(s):

Mitochondrial Dna ◽

Myelodysplastic Syndromes ◽

Sideroblastic Anemia ◽

The Role of Mitochondrial DNA Mutations in Hearing Loss

Biochemical Genetics ◽

10.1007/s10528-013-9589-6 ◽

2013 ◽

Vol 51 (7-8) ◽

pp. 588-602 ◽

Cited By ~ 35

Author(s):

Yu Ding ◽

Jianhang Leng ◽

Fan Fan ◽

Bohou Xia ◽

Pan Xu

Keyword(s):

Hearing Loss ◽

Mitochondrial Dna ◽

234 Role of mitochondrial DNA mutations in childhood MDS

Leukemia Research ◽

10.1016/s0145-2126(11)70236-3 ◽

2011 ◽

Vol 35 ◽

pp. S92

Author(s):

A. de Vries ◽

M. Zwaan ◽

B. Beverloo ◽

I. de Coo ◽

G. Schoonderwoerd ◽

...

Keyword(s):

Mitochondrial Dna ◽

S12. 10 Role of mitochondrial DNA mutations in periodontitis

Biochimica et Biophysica Acta (BBA) - Bioenergetics ◽

10.1016/j.bbabio.2008.05.305 ◽

2008 ◽

Vol 1777 ◽

pp. S77-S78 ◽

Cited By ~ 1

Author(s):

Praturi Gopalakrishna ◽

Periyasamy Govindaraj ◽

Ayyasamy Vanniarajan ◽

Rampalli Viswa Chandra ◽

Aileni Amarendra Reddy ◽

...

Keyword(s):

Mitochondrial Dna ◽

Role of Reactive Oxygen Species-elicited Apoptosis in the Pathophysiology of Mitochondrial and Neurodegenerative Diseases Associated With Mitochondrial DNA Mutations

Journal of the Formosan Medical Association ◽

10.1016/s0929-6646(09)60380-6 ◽

2009 ◽

Vol 108 (8) ◽

pp. 599-611 ◽

Cited By ~ 36

Author(s):

Chun-Yi Liu ◽

Cheng-Feng Lee ◽

Yau-Huei Wei

Keyword(s):

Reactive Oxygen Species ◽

Mitochondrial Dna ◽

Neurodegenerative Diseases ◽

Reactive Oxygen ◽

Oxygen Species ◽

Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss

Hearing Research ◽

10.1016/j.heares.2006.06.004 ◽

2007 ◽

Vol 226 (1-2) ◽

pp. 185-193 ◽

Cited By ~ 81

Author(s):

Tatsuya Yamasoba ◽

Shinichi Someya ◽

Chikako Yamada ◽

Richard Weindruch ◽

Tomas A. Prolla ◽

...

Keyword(s):

Hearing Loss ◽

Mitochondrial Dna ◽

Mitochondrial Dysfunction ◽

Dna Mutations ◽

Age Related ◽

Age Related Hearing Loss

Possible Role of Mitochondrial DNA Mutations in Chronification of Inflammation: Focus on Atherosclerosis

Journal of Clinical Medicine ◽

10.3390/jcm9040978 ◽

2020 ◽

Vol 9 (4) ◽

pp. 978 ◽

Cited By ~ 7

Author(s):

Alexander N. Orekhov ◽

Nikita N. Nikiforov ◽

Ekaterina A. Ivanova ◽

Igor A. Sobenin

Keyword(s):

Immune Response ◽

Innate Immunity ◽

Mitochondrial Dna ◽

Atherosclerotic Lesion ◽

Density Lipoprotein ◽

Health Impact ◽

Special Focus ◽

Chronification of inflammation is the process that lies at the basis of several human diseases that make up to 80% of morbidity and mortality worldwide. It can also explain a great deal of processes related to aging. Atherosclerosis is an example of the most important chronic inflammatory pathology in terms of public health impact. Atherogenesis is based on the inflammatory response of the innate immunity arising locally or focally. The main trigger for this response appears to be modified low-density lipoprotein (LDL), although other factors may also play a role. With the quick resolution of inflammation, atherosclerotic changes in the arterial wall do not occur. However, a violation of the innate immunity response can lead to chronification of local inflammation and, as a result, to atherosclerotic lesion formation. In this review, we discuss possible mechanisms of the impaired immune response with a special focus on mitochondrial dysfunction. Some mitochondrial dysfunctions may be due to mutations in mitochondrial DNA. Several mitochondrial DNA mutations leading to defective mitophagy have been identified. The regulatory role of mitophagy in the immune response has been shown in recent studies. We suggest that defective mitophagy promoted by mutations in mitochondrial DNA can cause innate immunity disorders leading to chronification of inflammation.