scholarly journals Perspectives on the History of Bovine TB and the Role of Tuberculin in Bovine TB Eradication

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Margaret Good ◽  
Anthony Duignan
Keyword(s):  
Test Performance ◽  
Bovine Tuberculosis ◽  
Accurate Determination ◽  
Tuberculin Test ◽  
Eradication Programme ◽  
History Of ◽  
Epidemiological Profile ◽  
Significant Disease

Tuberculosis remains a significant disease of animals and humans worldwide. Bovine tuberculosis is caused by Mycobacteria with an extremely wide host range and serious, although currently probably underdiagnosed, zoonotic potential. Where bovine tuberculosis controls are effective, human zoonotic TB, due toMycobacterium bovisorM. caprae, is uncommon and clinical cases are infrequent in cattle. Therefore, the control and ultimate eradication of bovine tuberculosis is desirable. Tuberculin tests are the primary screening tool used in bovine eradication. The choice of tuberculin test is dependent on the environment in which it is to be used. Tuberculin potency is critical to test performance, and the accurate determination of potency is therefore particularly important. The design of a control or eradication programme should take into consideration the fundamental scientific knowledge, the epidemiological profile of disease, the experience of other eradication programmes, and the presence, in the same ecosystem, of maintenance hosts, in which infection is self-sustaining and which are capable of transmitting infection. A control or eradication programme will necessarily require modification as it progresses and must be under constant review to identify the optimal desirable goals, the efficacy of policy, and constraints to progress.

scholarly journals The Significance of Death-Scene Investigation in Determining Cause and Circumstances of Medico-Legal Death

2019 ◽  
Vol 24 (38) ◽  
pp. 53-62
Author(s):  
Corina Crișan
Keyword(s):  
Accurate Determination ◽  
Massive Hemoptysis ◽  
Death Scene ◽  
First Case ◽  
Death Scene Investigation ◽  
Traumatic Lesions ◽  
Scene Investigation ◽  
Mechanical Asphyxia

Abstract The article presents two cases of the Arad Medico-Legal Department illustrating just a part of the role of the forensic pathologist at the death scene but there are sufficient to fully justify the importance of this investigation as no example can comprise the complexity of problems and the particularity of each case, nor a statistic can be made. Both cases were found dead at home and forensically autopsied, but the two of them were distinct in terms of forensic pathologist's request death scene participation. In the first case, the autopsy did not find traumatic lesions, but revealed that the death was due to massive hemoptysis caused by cavernous tuberculosis with subsequent exsanguination, microscopically confirmed. The death was nonviolent. In the second case, the autopsy revealed findings of mechanical asphyxia due to neck compression, both macroscopically and microscopically. The death was violent. In both cases the forensic expert participation is required at the death-scene. In the first case it allowed the correct interpretation of the traces of blood found on site, and in the second case, an onsite research would have properly helped for restoring the death‟s occurrence. The scene investigation and autopsy provide, together, the basis for an accurate determination of cause and circumstances of death.

Brain Death

2017 ◽  
Author(s):  
Anupamaa Seshadri ◽  
Ali Salim
Keyword(s):  
Brain Death ◽  
Apnea Test ◽  
Brainstem Reflex ◽  
Practice Parameters ◽  
Confirmatory Tests ◽  
History Of ◽  
Pediatric Populations ◽  
Definition Of

The concept of “brain death” is one that has been controversial over time, requiring the development of clear guidelines to diagnose and give prognoses for patients after devastating neurologic injury. This review discusses the history of the definition of brain death, as well as the most recent guidelines and practice parameters on the determination of brain death in both the adult and pediatric populations. We provide specific and detailed instructions on the various clinical tests required, including the brain death neurologic examination and the apnea test, and discuss pitfalls in the diagnosis of brain death. This review also considers the most recent literature and guidelines as to the role of confirmatory tests making this diagnosis.  Key Words: apnea test, brain death, brainstem reflex, death examination

scholarly journals Impact of Sleep Apnea on Cardioembolic Risk in Patients With Atrial Fibrillation

Stroke ◽  
2020 ◽  
Author(s):  
Martino F. Pengo ◽  
Andrea Faini ◽  
Ludger Grote ◽  
Ondrej Ludka ◽  
Pavol Joppa ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sleep Apnea ◽  
Accurate Determination ◽  
Oxygen Desaturation ◽  
Desaturation Index ◽  
Oxygen Desaturation Index ◽  
Obstructive Sleep ◽  
Initial Cohort

Background and Purpose: An accurate determination of the cardioembolic risk in patients with atrial fibrillation (AF) is crucial to prevent consequences like stroke. Obstructive sleep apnea (OSA) is a known risk factor for both AF and stroke. We aim to explore a possible association between OSA and an increased cardioembolic risk in patients with AF. Methods: We assessed data from the ESADA (European Sleep Apnea Database) cohort where patients with known AF and OSA were included. Parameters of OSA severity and related hypoxia like lowest Sp o 2 and 4% oxygen desaturation index were analyzed. Patients were stratified according to their cardioembolic risk estimated with the CHA 2 DS 2 -VASc score. Results: From the initial cohort of 14 646 patients, a final set of 363 patients were included in the analysis. Indices of hypoxia during sleep were associated with increased CHA 2 DS 2 -VASc score (4% oxygen desaturation index 17.9 versus 29.6 versus 30.5 events/hour and the lowest Sp o 2 81.2 versus 77.8 versus 77.5% for low, moderate, and high cardioembolic risk, respectively, P <0.05). Conclusions: These results support the potential role of OSA-related hypoxia in the risk for cardioembolic complications such as stroke in patients with AF.

scholarly journals 84. Over-Utilization of Prehospital Rapid Blood Glucose Measurements

1996 ◽  
Vol 11 (S2) ◽  
pp. S48-S48
Author(s):  
Edward A. Michelson ◽  
Kenneth S. Pearlman
Keyword(s):  
Abdominal Pain ◽  
Blood Glucose ◽  
Test Performance ◽  
Urban Population ◽  
Altered Mental Status ◽  
Level Of Consciousness ◽  
History Of ◽  
One Year ◽  
Not At Risk

Purpose: Determination of rapid blood glucose (RGB) by colorimetric stick test aids in the prehospital identification and treatment of hypoglycemia. The test may be applied unnecessarily to patients not at risk for, and in clinical situations not associated with hypoglycemia. We attempted to estimate the rate of over-utilization of RGB in a large urban EMS setting.Methods: All run sheets during a one week period from 7 sites providing radio command to both city and private EMS units serving a large urban population were screened. Those runs including RGB determination were further classified for presence or absence of a test indication. RGB was considered indicated with history or finding of: altered mental status, decreased level of consciousness, seizure, syncope and near syncope, generalized weakness or dizziness, with or without a history of diabetes.Results: 613 RGB determinations were identified during one week (annual rate = 31,876). 371 (61%) met indication criteria for test performance, and 242 (39%) failed to meet criteria. The patient complaint in cases not meeting criteria included; cardiac - 80, respiratory distress - 66, trauma - 38, abdominal pain -15, burns - 12, OB - 8, CVA - 6. Moreover, among these patients fewer than half had a history of diabetes. If this rate of over-utilization were maintained for one year, in excess of 12,500 extra tests would be performed in this system.

A history of bovine tuberculosis eradication policy in Northern Ireland

2015 ◽  
Vol 143 (15) ◽  
pp. 3182-3195 ◽  
Author(s):  
P. A. ROBINSON
Keyword(s):  
Northern Ireland ◽  
Bovine Tuberculosis ◽  
Animal Health ◽  
Historical Analysis ◽  
Eradication Programme ◽  
Agricultural Industry ◽  
The Public ◽  
History Of ◽  
The Uk ◽  
Public Archives

SUMMARYDespite many years of state-sponsored efforts to eradicate the disease from cattle through testing and slaughter, bovine tuberculosis (bTB) is still regarded as the most important and complex of animal health challenges facing the British livestock agricultural industry. This paper provides a historical analysis of the ongoing bTB statutory eradication programme in one part of the UK – Northern Ireland (NI) – which began in 1949 as a voluntary scheme, but between 1959 and 1960 became compulsory for all cattle herd-owners. Tracing bTB back through time sets the eradication efforts of the present day within a deeper context, and provides signposts for what developed in subsequent decades. The findings are based primarily on empirical research using historical published reports of the Ministry of Agriculture and state documents held in the public archives in NI, and they emphasize the need to consider the economic, social and political contexts of disease eradication efforts and their influences on both the past and the present.

Effect-Size Measures and Meta-Analytic Thinking in Counseling Psychology Research

2006 ◽  
Vol 34 (5) ◽  
pp. 601-629 ◽  
Author(s):  
Robin K. Henson
Keyword(s):  
Confidence Intervals ◽  
Statistical Significance ◽  
Effect Sizes ◽  
Analytic Thinking ◽  
Statistical Significance Testing ◽  
History Of ◽  
The Difference ◽  
Result Interpretation

Effect sizes are critical to result interpretation and synthesis across studies. Although statistical significance testing has historically dominated the determination of result importance, modern views emphasize the role of effect sizes and confidence intervals. This article accessibly discusses how to calculate and interpret the effect sizes that counseling psychologists use most frequently. To provide context, the author presents a brief history of statistical significance tests. Second, the author discusses the difference between statistical, practical, and clinical significance. Third, the author reviews and graphically demonstrates two common types of effect sizes, commenting on multivariate and corrected effect sizes. Fourth, the author emphasizes meta-analytic thinking and the potential role of confidence intervals around effect sizes. Finally, the author gives a hypothetical example of how to report and potentially interpret some effect sizes.

scholarly journals Fear of Death: A Systemic Description

2015 ◽  
Vol 11 (1) ◽  
pp. 13-23 ◽  
Author(s):  
A.A. Bakanova
Keyword(s):  
Content Analysis ◽  
Human Development ◽  
Theoretical Research ◽  
Fear Of Death ◽  
Defence Mechanisms ◽  
Ways Of Coping ◽  
History Of ◽  
Ontological Aspect

The paper presents a systemic description of the fear of death incorporating the following five basic aspects of its study in psychology: anthropologic, gnoseological, axiological, praxeological and ontological. Content analysis of each aspect is built upon theoretical research. Thus, the anthropological aspect is reviewed through the prism of various studies on the differences in experiencing the fear of dying throughout the history of mankind and throughout an individual's life. The gnoseological aspect is revealed through the issues of bio¬logical and social determination of the fear of death realized in explorations of its conscious and subconscious components explored in psychology. The axiological aspect is considered through its orientation (internal and external) and content components reflecting the basic values of an individual that are either destroyed or created by the idea of death. The praxeological aspect represents ways of coping with the fear of death, including various defence mechanisms. The ontological aspect is regarded as the integral one depicting the role of the fear of death in human development and its contributions to the formation of personality.

Determination of Leptin Adiponectin, LDL/HDL ratio with substantial role of Adiponectin and its Receptor

2021 ◽  
Vol 15 (10) ◽  
pp. 2550-2553
Author(s):  
Muhammad Ali Talat ◽  
Muhammad Shoaib ◽  
Sana Sabir ◽  
Uzair Mumtaz ◽  
Ambreen Tauseef ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Elisa Method ◽  
Metabolic Disturbances ◽  
Cross Sectional ◽  
Lipid Status ◽  
History Of ◽  
Obese Subjects ◽  
Suitable Marker

Aim: To determine Leptin/Adiponectin ratio, LDL/HDL ratio and AdipoR1 in obese and healthy subjects along with their respective lipid status. Methods: This cross-sectional comparative study was conducted in Sialkot city. One hundred and thirty-two participants took part in this research. Participants were equally divided into two groups containing non-obese and obese subjects. Mean age was 39.6±0.97 years. Mean BMI for obese subjects was 31.55±0.6 while non-obese group BMI was 20.5±0.2. Individuals with conditions and history of drugs were excluded. Informed and written consent was obtained prior to fasting blood sampling. Serum extraction and proper storage for later testing was carried out. ELISA method used for Adiponectin, AdiopR1 and leptin estimations while lipid profile was determined by Randox Diagnostics kits, using micro lab. SPSS v. 26. was used for comparison between by Mann-Whitney U tes. Results: Higher levels of Leptin/Adiponectin ratio(0.85±0.1) and LDL/HDL ratio (3.39 ± 0.1), serum Adiponectin (545± 73.3 ug/L), leptin (320.7±50.3 pg/mL) and AdipoR1 (28.9± 2.8 ng/mL) in obese when compared with healthy individuals, Leptin/Adiponectin ratio (0.44 ± 0.07 ) and LDL/HDL ratio (2.56 ± 0.08) Adiponectin (834± 70.6 ug/L), AdiopoR1 (17.8± 1.97 ng/mL), leptin (224.4±168.7 pg/mL). Correlation of adiponectin found positive for AdipoR1(r=0.336,p<0.05) and Leptin(r=0263,p<0.05) in obese subjects. L/A ratio correlated positive with leptin (r=0.644,p<0.05) in obese while in healthy subjects (leptin r=0.409,p<0.05,adiponectin r=-0.408,p<0.05 and HDL r=0.266,p<0.05).. Conclusion: The Leptin/Adiponectin ratio was found higher in obese subjects 0.85 as compared to healthy ones 0.44. Also the LDL/HDL ratio was found higher (3.39) when compared to non-obese (2.56), suggesting these ratios as a suitable marker to estimate metabolic disturbances and underlying dyslipidemia in the obese subjects. Key Words: Adiponectin, LDL/HDL ratio, Leptin, Leptin/Adiponectin ratio, Obesity

Role of fractionation correction in accurate determination of 142Nd/144Nd by TIMS: A case study of 1.48 Ga alkaline rocks from Khariar, India

2017 ◽  
Vol 466 ◽  
pp. 479-490 ◽  
Author(s):  
Ikshu Gautam ◽  
Jyotiranjan S. Ray ◽  
Rajneesh Bhutani ◽  
S. Balakrishnan ◽  
J.K. Dash
Keyword(s):  
Accurate Determination ◽  
Alkaline Rocks

scholarly journals Advances in the investigation of shock-induced reflectivity of porous carbon

2013 ◽  
Vol 31 (3) ◽  
pp. 457-464 ◽  
Author(s):  
Dimitri Batani ◽  
Stefano Paleari ◽  
Tommaso Vinci ◽  
Roberto Benocci ◽  
Keisuke Shigemori ◽  
...  
Keyword(s):  
Shock Waves ◽  
Numerical Simulations ◽  
Porous Carbon ◽  
Simultaneous Measurement ◽  
Accurate Determination ◽  
Sample Temperature ◽  
Optical Pyrometry ◽  
Shock Dynamics

AbstractWe studied the behavior of porous carbon compressed by laser-generated shock waves. In particular, we developed a new design for targets, optimized for the investigation of carbon reflectivity at hundred-GPa pressures and eV/k temperatures. Specially designed “two-layer-two materials” targets, comprising porous carbon on transparent substrates, allowed the probing of carbon reflectivity and a quite accurate determination of the position in the P, T plane. This was achieved by the simultaneous measurement of shock breakout times, sample temperature (by optical pyrometry) and uid velocity. The experiments proved the new scheme is reliable and appropriate for reflectivity measurements of thermodynamical states lying out of the standard graphite or diamond hugoniot. An increase of reflectivity in carbon has been observed at 260 GPa and 14,000 K while no increase in reflectivity is found at 200 GPa and 20,000 K. We also discuss the role of numerical simulations in the optimization of target parameters and in clarifying shock dynamics.

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