scholarly journals Case of generalized morphea complicated with systemic sclerosis

2021 ◽  
Author(s):  
Soichiro Sawamura ◽  
Katsunari Makino ◽  
Hitomi Nakashima ◽  
Takamitsu Makino ◽  
Satoshi Fukushima
Keyword(s):  
Systemic Sclerosis ◽  
Rare Case ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Clinical Presentations

Dear Editor, Localized scleroderma (LSc; morphea) is a rare fibrosing disease of the skin and underlying tissues, which is different from systemic sclerosis (SSc). 1 LSc is classified based on clinical presentations: circumscribed, linear, generalized, pansclerotic, and mixed morphea. 1 Generalized morphea (GM) , which is characterized by widespread skin lesions with multiple indurated plaques or hyperpigmentation, is a relatively rare subtype occurring in 7-9% of patients with LSc. 1 Previous studies have shown that SSc can be complicated by GM, separately from GM-like SSc. Here, we present a rare case of coexistence of LSc and SSc in which LSc skin lesions appeared before SSc became apparent [...].

Clinical Manifestations of Scleroderma

1995 ◽  
Vol 16 (2) ◽  
pp. 49-49
Author(s):  
Patricia L. Haber
Keyword(s):  
Systemic Sclerosis ◽  
Connective Tissue ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Unknown Etiology ◽  
Collagen Deposition ◽  
Muscle Fibrosis ◽  
Favorable Prognosis ◽  
Organ Systems

Scleroderma is a connective tissue disease of unknown etiology. Its most characteristic feature is thickening of the skin due to increased collagen deposition. However, the disease may involve multiple other organ systems. Two broad categories of scleroderma have been defined: localized and systemic. Although all forms of scleroderma are rare, localized scleroderma occurs more frequently than systemic sclerosis and has a more favorable prognosis. Several types of localized scleroderma exist. Morphea is characterized by the presence of one or more patches of hard, ivory-colored skin lesions. They begin with erythema and progress to nonpitting edema before becoming sclerotic. The margins of active lesions often have a violaceous hue. Underlying muscle fibrosis and atrophy may occur.

scholarly journals Localized Scleroderma, Systemic Sclerosis and Cardiovascular Risk: A Danish Nationwide Cohort Study

2018 ◽  
Vol 98 (3) ◽  
pp. 361-365 ◽  
Author(s):  
J Hesselvig ◽  
K Kofoed ◽  
J Wu ◽  
L Dreyer ◽  
G Gislason ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cardiovascular Risk ◽  
Systemic Sclerosis ◽  
Localized Scleroderma

Unique digital skin lesions associated with systemic sclerosis

1997 ◽  
Vol 136 (4) ◽  
pp. 598-600 ◽  
Author(s):  
A.V. MARZANO ◽  
E. BERTI ◽  
G. GASPARINI ◽  
A. VESPASIANL ◽  
R. SCORZA ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Skin Lesions

scholarly journals Invasive aspergillosis with disseminated skin ınvolvement in a patient with acute myeloid leukemia: a rare case

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Duygu Mert ◽  
Gülşen Iskender ◽  
Fazilet Duygu ◽  
Alparslan Merdin ◽  
Mehmet Sinan Dal ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Invasive Aspergillosis ◽  
Myeloid Leukemia ◽  
Rare Case ◽  
Invasive Pulmonary Aspergillosis ◽  
Skin Lesions ◽  
Immunocompromised Patients ◽  
Skin Involvement ◽  
Pulmonary Aspergillosis ◽  
Acute Myeloid

Invasive pulmonary aspergillosis is most commonly seen in immunocompromised patients. Besides, skin lesions may also develop due to invasive aspergillosis in those patients. A 49-year-old male patient was diagnosed with acute myeloid leukemia. The patient developed bullous and zosteriform lesions on the skin after the 21st day of hospitalization. The skin biopsy showed hyphae. Disseminated skin aspergillosis was diagnosed to the patient. Voricanazole treatment was initiated. The patient was discharged once the lesions started to disappear.

scholarly journals A Case of Rupioid Syphilis Masquerading as Aggressive Cutaneous Lymphoma

2015 ◽  
Vol 7 ◽  
pp. e2015026 ◽  
Author(s):  
Jonathan Braue ◽  
Thomas Hagele ◽  
Abraham Tareq Yacoub ◽  
Suganya Mannivanan ◽  
Frank Glass ◽  
...  
Keyword(s):  
19Th Century ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Rare Case ◽  
Skin Lesions ◽  
Secondary Syphilis ◽  
Cutaneous Lymphoma ◽  
Hiv Positive ◽  
Late 19Th Century ◽  
Inflammatory Syndrome

Secondary syphilis has been known since the late 19th century as the great imitator; however, some experts now regard cutaneous lymphoma as the great imitator of skin disease. Either disease, at times an equally fastidious diagnosis, has reported to even mimic each other. It is thus vital to consider these possibilities when presented with a patient demonstrating peculiar skin lesions. No other manifestation of secondary syphilis may pose such quandary as a rare case of rupioid syphilis impersonating cutaneous lymphoma. We present such a case, of a 36-year-old HIV positive male, misdiagnosed with aggressive cutaneous lymphoma, actually exhibiting rupioid syphilis thought secondary to immune reconstitution inflammatory syndrome (IRIS).

scholarly journals A very rare case of FLT3-D835 positive blastic plasmacytoid dendritic cell neoplasm

2020 ◽  
Vol 7 (4) ◽  
pp. 57-62
Author(s):  
Vlad Andrei Cianga ◽  
Cătălin Doru Dănăilă ◽  
Ion Antohe
Keyword(s):  
Dendritic Cell ◽  
Rare Case ◽  
Elderly Population ◽  
Hematological Malignancies ◽  
Plasmacytoid Dendritic Cell ◽  
The Elderly ◽  
Skin Lesions ◽  
Response To Treatment ◽  
Cell Neoplasm ◽  
Immuno Histochemistry

Blastic plasmacytoid dendritic cell neoplasms (BPDCNs) are extremely rare and aggressive hematological malignancies that derive from precursors of plasmacytoid dendritic cells (pDC) and frequently involve skin lesions and bone marrow infiltration. They mostly affect the elderly population and the prognosis is poor with the therapeutic choices currently available. Diagnosis is made with the help of tools such as immuno-histochemistry and flow cytometry. Here, we present a particular case of BPDCN with a positive FLT3-D835 mutation and we discuss the possible impact this may have on the evolution of the disease and response to treatment.

scholarly journals Inflammatory Pseudotumour of Stomach in an old lady: a rare case report

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Azhar AH ◽  
Pasha MA ◽  
Hassan S ◽  
Zainal M ◽  
Rashidi A
Keyword(s):  
Case Report ◽  
Solid Tumor ◽  
Rare Case ◽  
Clinical Presentation ◽  
Inflammatory Pseudotumour ◽  
Secondary Neoplasms ◽  
Laboratory Techniques ◽  
Clinical Presentations ◽  
Rare Case Report ◽  
Adults And Children

Inflammatory pseudotumour (IPT) is a rare benign solid tumor in adults and children. The prevalence, etiology and pathogenesis of this condition are still uncertain. Despite the use of modern laboratory techniques and imaging, it is often difficult to make the diagnosis of IPT. Besides, occasionally the nonspecific morphological appearance and clinical presentation of the mass may mimic other more common primary or secondary neoplasms. IPT is commonly encountered in the lung and mediastinum. Other sites include abdomen (liver, pancreas, stomach, omentum), retroperitoneum, pelvis (bladder) and extremities in children. We report a rare case of gastric inflammatory pseudotumour in a 65-year-old female patient. Clinical presentations and its management along with review of literatures are presented.

scholarly journals Gender, clinical and topographic features of the localized scleroderma lesions in anogenital area

2020 ◽  
Vol 23 (3) ◽  
pp. 165-173
Author(s):  
Elena S. Snarskaya ◽  
Yulia A. Semenchak
Keyword(s):  
Clinical Symptoms ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Steady Increase ◽  
Family Doctors ◽  
Topographic Features ◽  
Anogenital Area ◽  
Clinical Variants ◽  
Limited Scleroderma ◽  
And Gender

Background: Currently, there is an increase in the number of skin lesions of anogenital localization, which is a silent epidemic, both due to the steady increase in the incidence of this pathology, and the interdisciplinary aspect of this problem. Materials and methods: In the article, the authors first analyzed and presented the data of clinical and morphological analysis of 104 patients with various clinical variants of limited scleroderma, on the basis of which the main phenotypic and gender-specific clinical and topographical features of anogenital zone lesions in this group of patients are presented. Results: Scleroatrophic lichen is one of the clinical variants of limited scleroderma, which is characterized by damage to the mucous membranes of the external genitals in both women and men. Lesions of such localization are late and often mistakenly diagnosed by specialists of related disciplines (obstetricians, gynecologists, urologists, family doctors, allergists, cosmetologists), which leads to high risks of developing genitourenal syndrome. Conclusions: The development of scleroatrophic lesions in the anogenital zone is accompanied by pronounced clinical symptoms, including: itching, pain of varying intensity, dysuria, dyspareunia and significant sexual dysfunction.

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