Tsukamurella catheter-related bloodstream infection in a pediatric patient with pulmonary hypertension

Catheter-related bloodstream infections (CR-BSI) are important complications in patients with long-term indwelling central venous catheters. In this report, we present the case of a 14-year-old male with pulmonary hypertension treated with continuous treprostinil infusion, who presented with a CR-BSI caused by a Tsukamurella species. This case highlights the potential for this unusual organism to cause infection in immunocompetent patients.

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Long-Term Silicone Central Venous Catheters Impregnated With Minocycline and Rifampin Decrease Rates of Catheter-Related Bloodstream Infection in Cancer Patients: A Prospective Randomized Clinical Trial

Journal of Clinical Oncology ◽

10.1200/jco.2004.04.124 ◽

2004 ◽

Vol 22 (15) ◽

pp. 3163-3171 ◽

Cited By ~ 140

Author(s):

Hend Hanna ◽

Robert Benjamin ◽

Ioannis Chatzinikolaou ◽

Badie Alakech ◽

Deborah Richardson ◽

...

Keyword(s):

Clinical Trial ◽

Cancer Patients ◽

Bloodstream Infection ◽

Tertiary Care ◽

Bloodstream Infections ◽

Central Venous Catheters ◽

Care Hospital ◽

Central Venous ◽

Catheter Related Bloodstream Infection

PurposeTo evaluate the efficacy of long-term nontunneled silicone catheters impregnated with minocycline and rifampin (M-R) in reducing catheter-related bloodstream infections.Patients and MethodsThis prospective, randomized, double-blind clinical trial was conducted at M.D. Anderson Cancer Center, a tertiary care hospital in Houston, TX. All patients in the trial had a malignancy.ResultsBetween September 1999 and May 2002, 356 assessable catheters were used: 182 M-R and 174 nonimpregnated. The patients' characteristics were comparable between the two study groups. The mean (± standard deviation) duration of catheterization with M-R catheters was comparable to that of nonimpregnated catheters (66.21 ± 30.88 v 63.01 ± 30.80 days). A total of 17 catheter-related bloodstream infections occurred during the course of the study. Three were associated with the use of M-R catheters and 14 were associated with the nonimpregnated catheters, with a rate of catheter-related bloodstream infection of 0.25 and 1.28/1,000 catheter-days, respectively (P = .003). Gram-positive cocci accounted for the majority of the organisms causing the infections. There were no allergic reactions associated with M-R catheters.ConclusionLong-term nontunneled central venous catheters impregnated with minocycline and rifampin are efficacious and safe in reducing catheter-related bloodstream infections in cancer patients.

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Clinical usefulness of catheter-drawn blood samples and catheter-tip cultures for the diagnosis of catheter-related bloodstream infections in neonates

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2020.95 ◽

2020 ◽

Vol 41 (7) ◽

pp. 854-856

Author(s):

Janita Ferreira ◽

Paulo Augusto Moreira Camargos ◽

Viviane Rosado ◽

Leni Márcia Anchieta ◽

Roberta Maia de Castro Romanelli

Keyword(s):

Adverse Events ◽

Bloodstream Infection ◽

Efficient Method ◽

Bloodstream Infections ◽

Central Venous Catheters ◽

Blood Sampling ◽

Central Venous ◽

Blood Samples ◽

Catheter Tip ◽

Catheter Related Bloodstream Infection

AbstractCatheter-drawn blood sampling is an efficient method of diagnosing catheter-related bloodstream infection (CRBSI) in neonates; it has greater sensitivity and accuracy than methods using catheter-tip cultures. No association was detected between catheter-drawn blood sampling and the occurrence of adverse events with central venous catheters.

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Antimicrobial Impregnated Catheters in the Prevention of Catheter-Related Bloodstream Infection in Hospitalized Patients

The Journal of Pediatric Pharmacology and Therapeutics ◽

10.5863/1551-6776-12.2.77 ◽

2007 ◽

Vol 12 (2) ◽

pp. 77-90

Author(s):

Sarah K. Wassil ◽

Catherine M. Crill ◽

Stephanie J. Phelps

Keyword(s):

Bloodstream Infection ◽

Bloodstream Infections ◽

Central Venous Catheters ◽

Hospitalized Patients ◽

Central Venous ◽

Related Factors ◽

Future Directions ◽

The Cost ◽

Care Costs ◽

Catheter Related Bloodstream Infection

Catheter-related bloodstream infections have a significant impact on increasing health care costs and morbidity and mortality in hospitalized patients. Many technologies have been created in an attempt to decrease the incidence of catheter-related bloodstream infection. One of these is the impregnation of central venous catheters with antiseptics (e.g., chlorhexidine and silver sulfadiazine) or antibiotics (e.g., minocycline and rifampin). While studies evaluating the efficacy of impregnated catheters have been conducted, the data are limited and their use remains variable across institutions. This paper will discuss catheter-related factors that predispose patients to catheter-related bloodstream infection, the types of antimicrobial-impregnated catheters in use today, studies evaluating their efficacy, and common concerns associated with the use of these catheters. Issues related to the cost-effectiveness of impregnated catheters and future directions for the prevention of catheter-related bloodstream infection will also be presented.

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Prospective Incidence Study of Bloodstream Infection in Infants and Children With Central Venous Catheters After Cardiac Surgery in Italy

Infection Control and Hospital Epidemiology ◽

10.1086/598242 ◽

2009 ◽

Vol 30 (7) ◽

pp. 698-701 ◽

Cited By ~ 4

Author(s):

Stefania Bezzio ◽

C. Scolfaro ◽

R. Broglia ◽

R. Calabrese ◽

F. Mignone ◽

...

Keyword(s):

Risk Factors ◽

Cardiac Surgery ◽

Observational Study ◽

Bloodstream Infection ◽

Medical Staff ◽

Prospective Observational Study ◽

Central Venous Catheters ◽

Central Venous ◽

In Infants And Children ◽

Catheter Related Bloodstream Infection

This prospective observational study was designed to assess the incidence of, risk factors for, and outcome of catheter-related bloodstream infection in children undergoing cardiac surgery. A staff specifically trained to handle the central venous catheters with proper aseptic techniques and an appropriate patient to medical staff ratio remain the most effective measures to prevent this infection.

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