scholarly journals Clinicopathologic characteristics of primary pleural epithelioid hemangioendothelioma

2011 ◽  
Vol 4 (4) ◽  
pp. 219
Author(s):  
Chad A. Reade ◽  
Apar Kishor Ganti ◽  
Anne Kessinger
Keyword(s):  
Spontaneous Remission ◽  
Epithelioid Hemangioendothelioma ◽  
Low Grade ◽  
Clinicopathologic Characteristics ◽  
Short Survival ◽  
History Of ◽  
Therapeutic Measures ◽  
Long Life ◽  
Grade Malignancy ◽  
The Right

Epithelioid hemangioendothelioma (EHE) is a rare vascular-derived malignancy. Within the thorax, EHE originating in the pleura is less often reported than EHE originating in the lung. Pulmonary EHE has been referred to as a borderline or low-grade malignancy that exhibits an unpredictable course. It often is associated with a long life expectancy and occasional spontaneous remission. Because the natural history of pleural EHE is less well understood, a literature review was conducted to investigate the characteristics of the disease. Twenty-two cases of pleural EHE were identified. The disease occurred more often in men than women, appeared in the right thorax more often than the left, exhibited a virulent course, was usually refractory to systemic therapy, and was often associated with a short survival. These characteristics differ substantially from those of pulmonary EHE and suggest that the clinician should approach pleural EHE anticipating an especially aggressive malignancy which likely will not respond to current therapeutic measures.

scholarly journals Gigantinė retroperitoninio tarpo lipoma: klinikinis atvejis ir literatūros apžvalga

2012 ◽  
Vol 10 (1-2) ◽  
pp. 0-0
Author(s):  
Edgaras Kulikauskas ◽  
Eligijus Poškus ◽  
Dileta Rutkauskaitė ◽  
Kęstutis Strupas
Keyword(s):  
Large Mass ◽  
University Hospital ◽  
Pathological Examination ◽  
Low Grade ◽  
Vilnius University ◽  
Grade Malignancy ◽  
The Right ◽  
E Mail ◽  
Slow Growing ◽  
Primary Retroperitoneal

Edgaras Kulikauskas1, Eligijus Poškus1, Dileta Rutkauskaitė2, Kęstutis Strupas1 1Vilniaus universiteto ligoninės Santariškių klinikų Gastroenterologijos, nefrologijos, urologijos ir abdominalinės chirurgijos klinika, Santariškių g. 2, LT-08661 Vilnius2Vilniaus universiteto Medicinos fakulteto Krūtinės ligų, alergologijos ir radiologijos klinika, Santariškių g. 2, LT-08661 Vilnius El. paštas: [email protected] Pirminiai retroperitoniniai navikai yra reti, pasižymintys didele histologine įvairove. Apie 80 proc. pirminių retroperitoninio tarpo navikų yra piktybiniai, o gerybinės lipomos šioje vietoje aptinkamos labai retai. Augdamos lėtai lipomos gali pasiekti 20 cm dydį ir kelių kilogramų svorį, nesukeldamos ryškesnės simptomatikos. Šių nepiktybinių navikų diagnostika remiasi radiologiniais tyrimais. Atskirti lipomas nuo piktybinių riebalinių navikų, ypač geros diferenciacijos liposarkomomis, kurios retai metastazuoja, tačiau pasižymi dideliu recidyvų dažnumu, gali būti labai sudėtinga. Dėl šių priežasčių riebaliniai retroperitoninio tarpo navikai turi būti vertinami kaip liposarkomos, kol neįrodoma kitaip. Radikalus chirurginis naviko pašalinimas yra pirmiausia pasirenkamas gydymo metodas.Pateikiame klinikinį retroperitoninės lipomos, nustatytos 61 metų amžiaus vyrui, gydymo atvejį. Navikas diagnozuotas remiantis klinika ir kompiuterinės tomografijos tyrimu. Operacijos metu rasta ir pašalinta 40 × 40 × 20 cm dydžio, 6500 g svorio lipoma, diagnozė patvirtinta histologinio tyrimo metu. Devintą parą po operacijos, ligonis išrašytas į namus. Reikšminiai žodžiai: retroperitoninis tarpas, lipoma, chirurgija. Giant retroperitoneal lipoma: case report and literature review Edgaras Kulikauskas1, Eligijus Poškus1, Dileta Rutkauskaitė2, Kęstutis Strupas1 1Clinic of Gastroenterology, Urology and Abdominal Surgery, Vilnius University Hospital “Santariškių klinikos”, Santariškių Str. 2, LT-08661 Vilnius, Lithuania2Vilnius University, Medical Faculty, Clinic of Chest Diseases, Allergology and Radiology, Santariškių Str. 2, LT-08661 Vilnius, Lithuania E-mail: [email protected] Primary retroperitoneal tumours are rare and show a high histological variety. About 80% of retroperitoneal tumours are malignant; benign lipomas in this location are exceptionally rare. These slow-growing tumors can grow up to more than 20 cm and weight a few kilograms. The differential diagnosis of lipomas with liposarcomas may be problematic, especially for tumours with low-grade malignancy, which have a predilection for local recurrence but do not generally metastatize. Fatty tumours of the retroperitoneum should be considered to be potential liposarcomas until proven otherwise, and a radical lesion excision should always be performed, if possible.We report a case of a giant retroperitoneal lipoma in a 61-year-old male. A CT scan of his abdomen showed a large mass of fat density displacing organs to the right side. The patient underwent a radical tumour excision. Laparotomy showed a giant fatty mass measuring 40 x 40 x 20 cm and weighing 6500 g. The pathological examination revealed benign lipoma. The patient was discharged home on postoperative day 9. Key words: retroperitoneal space, lipoma, surgery

scholarly journals A Case of Vanishing Metastatic Mass: Right Atrial Mass in the Setting of Primary Epithelioid Hemangioendothelioma of the Spine

2018 ◽  
Vol 11 (2) ◽  
pp. 534-540 ◽  
Author(s):  
Eshan Patel ◽  
P. Kancharla ◽  
B.K. Surapaneni ◽  
K. Hennrick ◽  
M. Goldfinger ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Epithelioid Hemangioendothelioma ◽  
The Body ◽  
Right Atrial ◽  
Low Grade ◽  
Vascular Neoplasm ◽  
Right Atrial Mass ◽  
Progression Of Disease ◽  
The Right ◽  
Age And Sex

Epithelioid hemangioendothelioma (EHE) is a rare low-grade vascular neoplasm that is characterized as intermediate between benign hemangioma and high-grade angiosarcoma affecting 1 in 1,000,000 people worldwide. It has been described throughout the body with lung, liver, skin, and bone being the most frequent sites. Primary EHE of the spine has been reported in 56 cases so far with no correlation of age and sex. Our case highlights a rare clinical presentation, etiopathogenesis, diagnosis, and treatment of EHE of the spine with metastasis to the right atrium. This is the first documented case of EHE of the spine with metastatic spread to the heart treated with bevacizumab leading to resolution of the heart metastatic mass. Further studies are warranted to develop a treatment formula for this rare tumor, to consider combination chemotherapy and new adjuvant targeted immunotherapies to prevent progression of disease.

scholarly journals Pazopanib in Pulmonary Epithelioid Hemangioendothelioma: Report of a Case

2020 ◽  
Vol 5 (02) ◽  
Author(s):  
Ibtihal Ahalli ◽  
Karima Oualla ◽  
Loubna Hejjane ◽  
Raihana Boujarnija ◽  
Kaouthar Messoudi ◽  
...  
Keyword(s):  
Lung Tumor ◽  
Vascular Tumor ◽  
Epithelioid Hemangioendothelioma ◽  
Low Grade ◽  
Vegf Receptor ◽  
Vascular Endothelial ◽  
Pulmonary Epithelioid Hemangioendothelioma ◽  
Grade Malignancy ◽  
Rare Malignancy ◽  
Endothelial Growth Factor

Pulmonary epithelioid hemangioendothelioma (PEH) is a rare vascular tumor of borderline or low-grade malignancy, Vascular endothelial growth factor (VEGF) and the VEGF receptor were found on PEH tumor cells, suggesting that target therapies that block VEGFR have a logical base in this rare malignancy. We report a 25 years old woman with a pulmonary hemangioendothelioma, treated with pazopanib, the only anti angiogenic registered agent for sarcoma, with clinical improvement of symptoms and durable stabilization for more than two years of lung tumor.

scholarly journals Clinical Characteristic and Prognosis of Epithelioid Hemangioendothelioma: 35 Cases from Single Center in Recent Decade

2020 ◽  
Author(s):  
Qiaoqi Li ◽  
Lede Lin ◽  
Jielang Li ◽  
Xiaojuan Zhou ◽  
Yong Xu
Keyword(s):  
Survival Rate ◽  
Cox Regression ◽  
Case Series ◽  
Recent Decade ◽  
Epithelioid Hemangioendothelioma ◽  
P Value ◽  
Low Grade ◽  
Imaging Data ◽  
Ki 67 ◽  
Grade Malignancy

Abstract Backgrounds: Epithelioid hemangioendothelioma (EHE) is a rare carcinoma worldwide with low-grade malignancy. Few reports have evaluated large case series of EHE. And we tried to describe different treatment and the overall survival rate of EHE, exploring prognostic the factors of outcome.Methods: This was a retrospective study enrolling patients diagnosed with EHE in our center from June 2009 to March 2020. Data including demographic characteristics, laboratory date, treatments, imaging data, immunohistochemical results, follow-up results were collected, and a retrospective database was constructed for analysis.Results: This study enrolled 35 patients with EHE pathologically diagnosed in our center. We reported the mean onset age was 41 years old, ranging from 3 to 70. EHE was more common in female patients (60%). The most commonly affected organ was liver (63%). The 5-year survival rate was 62.86%. After we operated COX regression analyse to test the effect of age (≥55 years old or <55 years old), sex, position (multiple organs or single organ involved), symptoms (symptomatic or asymptomatic) and Ki-67 (≥10% or <10%) on disease outcome, we only found that Ki-67 was the independent factor affecting the prognosis, with significant P value equal to 0.034 and hazard ratio equal to 5.809.Conclusions: In conclusion, EHE has relatively low-grade malignancy and its 5-year survival rate is 62.86%. EHE patients whose Ki-67≥10% tended to experience poor outcome.

scholarly journals Unusual biological behavior of femoral liposarcoma

2007 ◽  
Vol 135 (7-8) ◽  
pp. 468-471 ◽  
Author(s):  
Milan Stojanovic ◽  
Branislav Goldner ◽  
Spasenija Djukic
Keyword(s):  
Biological Behavior ◽  
Low Grade ◽  
High Grade ◽  
Therapeutic Protocol ◽  
Grade Of Malignancy ◽  
Males And Females ◽  
Grade Malignancy ◽  
The Right ◽  
High Grade Malignancy ◽  
Scapular Region

Introduction Liposarcoma of a bone is a very rare tumor of the fatty marrow, originating from lipoblasts. Its frequency is 1:1000 of all bone tumors. The long bones and the lower extremities are predominantly affected, equally in males and females between 30 and 70 years of age. In the estimation of its biological behavior, histological graduation (G), the surgical localization of the tumor (T) and the presence or absence of metastases (M), are very important. A tumor with low grade differentiation, with transosseal propagation and metastases, has a poor prognosis. Surgical resection-amputation, chemotherapy and radiotherapy are the therapeutic methods of choice. Case outline Twelve years ago, in a 58-year old man, there was a radiologically diagnosed sarcoma in the lower part of the right femur manifested with painful swelling in that region. The high suprapatellar amputation was done. There was a histologically proved liposarcoma of a high grade of malignancy. According to the therapeutic protocol, chemotherapy and radiotherapy were applied. During the period of 12 years, the patient had a relapse on the stump, metastatic dissemination in the soft tissue of small pelvis twice, once in the left scapular region and in the inguinal lymph nodes, six operations and 8-year accumulation of metastatic deposits in the lung. Now, the patient feels relatively well, mobile, and walks 5 kilometres every day. Conclusion Unusual behaviour of the liposarcoma of high grade malignancy with which the patient has been living for 12 years, could be explained by the patient?s strong immunobiological system in the struggle to retain its vitality and mobility.

Biodegradable Antibiotic Delivery Systems in the treatment chronic osteomyelitis

2014 ◽  
Vol 2 (2) ◽  
pp. 73-77
Keyword(s):  
Chronic Osteomyelitis ◽  
Past History ◽  
Delivery Systems ◽  
Subsequent Treatment ◽  
Passive Movement ◽  
Residential Home ◽  
Low Grade ◽  
History Of ◽  
The Right ◽  
Antibiotic Delivery

An 82-year-old woman was referred to the orthopedic department with a three-month history of low-grade fever. She had a known past history of type 2 diabetes. She had been unwell for last 5-days, complaining of feeling hot and 'shivery' with general aches, particularly in her right shoulder. The staff in the residential home where she lived had called the general practitioner who had prescribed a three-day course of trimethoprim for a suspected urinary tract infection. On examination, she was pyrexia with a temperature of 39.5°C. She was drowsy but reusable. Pulse was 125 beats per minute and regular. Blood pressure was 90/55 mmHg. Heart sounds were normal with no added sounds or murmurs. The chest was clear. Her abdomen was soft and non-tender with no palpable masses or organs. The skin overlying the right shoulder was warm to touch and erythematous. She was unable to tolerate any passive movement of the joint. A plain x ray of her shoulder shows lucent defects in the head of the humerus with loss of the normally well-corticated surface. This is consistent with osteomyelitis. Two of 2-blood cultures and numerous operative cultures grew MRSA. His subsequent treatment consisted of intravenous vancomycin, achieving plasma drug levels approximating 24 μg/mL. This treatment was extended for 8 weeks, given the clinical concern for possible osteomyelitis in an area. Treatment was complicated by significant a decline in hearing. Biodegradable drug delivery systems provide a method for local delivery of drugs in deeper tissues, obviating parenteral or enteral usage; in some situations, a significant advantage is that much higher doses and/or strengths of the drug can be delivered locally than can be tolerated if the drug is delivered systemically. In this case report, we discussed the use of Biodegradable Antibiotic Delivery Systems in treatment chronic osteomyelitis.

scholarly journals Parasitic Myoma: A Very Rare Case Report aAnd Review of Literature

2019 ◽  
Vol 17 (1) ◽  
pp. 50-53
Author(s):  
Md Manir Hossain Khan ◽  
Jobaida Sultana
Keyword(s):  
Abdominal Wall ◽  
Blood Supply ◽  
Iliac Fossa ◽  
Abdominal Cavity ◽  
Low Grade ◽  
Review Of Literature ◽  
Rare Case Report ◽  
History Of ◽  
The Right ◽  
Further Development

A 32 years old unmarried women presented with periumbilical colickey abdominal pain which shiftted to the right iliac fossa with anorexia, vomiting and low grade fever. She had history of open myomectomy 4 years back for menorrhagia with multiple fibroids (myomas). On examination, the pointing sign, Rovsing's sign, McBurney's sign &Blumberg's sign were positive. Then she was diagnosed as a case of acute appendicitis. Ultrasonography revealed nothing significant. Appendicectomy was done through right Grid Iron incision. Appendix was found inflammed, swollen and there was collection of fluid in the peritoneal cavity. During closure, incidentally a solid mass about 5 ><4 ><2.5 cm was found exterior to the peritoneum near the incision at the abdominal wall. The mass was excised. Subsequently histopathotology confirmed a leiomyoma (Myoma or parasitic fibroid). The parasitic myoma may develop spontaneously as pedanculatedsubcerousmyomaloose their uterine blood supply or iatrogenically from retained fragment of myoma from previous myomectomy or hysterectomy and get blood supply from abdominal wall. Even small bits displaced into the abdominal cavity can result in parasitic fibroids. This case is reported here to give emphasis on the surveilence of parasitic myoma during myomectomy or hysterectomy for fibroid uterus and all tissue pieces that are morcellated should be delligently removed for the prevention of further development of parasitic myoma. Journal of Surgical Sciences (2013) Vol. 17 (1) : 50-53

AIDS presenting as radial bone tuberculosis and pyogenic methicillin-sensitive Staphylococcus aureus osteomyelitis

2020 ◽  
Vol 13 (10) ◽  
pp. e236802
Author(s):  
Nigel Jeronimo Cortez Santos ◽  
Isabelle Dominique Villegas Tomacruz ◽  
Frances Lina Lantion-Ang ◽  
Paula Veronica San Juan Reyes
Keyword(s):  
Staphylococcus Aureus ◽  
Purulent Discharge ◽  
Team Approach ◽  
Low Grade ◽  
Successful Infection ◽  
History Of ◽  
Bone Tuberculosis ◽  
The Right ◽  
Pyogenic Osteomyelitis ◽  
Radial Bone

Osteomyelitis is a rare initial presentation of HIV. We report a case of a 25-year-old, apparently well man presenting with a traumatic, pathological fracture of the right radius. He had a 2-week history of low-grade fever, swelling and purulent discharge of the radial aspect of his right forearm. Osteomyelitis, secondary bacteraemia and pneumonia were clues that led physicians to test for HIV. Multiple debridement, sequestrectomy and vacuum-assisted closure were done. Tissue cultures revealed Mycobacterium tuberculosis (TB) and methicillin-sensitive Staphylococcus aureus. He was treated successfully with 6 weeks of culture-guided intravenous oxacillin, staphylococcal decontamination and first-line anti-TB regimen (rifampicin, isoniazid, ethambutol, pyrazinamide). Antiretroviral agents were started thereafter. Successful infection control and preservation of limb functionality was achieved with a multidisciplinary team approach. To our knowledge this is the first reported case of an adult patient with HIV presenting with tuberculous and pyogenic osteomyelitis of the radial bone.

scholarly journals Glioblastoma multiforme of the pineal region: case report

2003 ◽  
Vol 61 (2B) ◽  
pp. 468-472 ◽  
Author(s):  
Emerson Leandro Gasparetto ◽  
Danny Warszawiak ◽  
Guilherme Pradi Adam ◽  
Luiz Fernando Bleggi-Torres ◽  
Arnolfo de Carvalho Neto
Keyword(s):  
Glioblastoma Multiforme ◽  
Parenchymal Cell ◽  
Pineal Region ◽  
Low Grade ◽  
Babinski Sign ◽  
Pineal Region Tumors ◽  
Nuchal Rigidity ◽  
History Of ◽  
The Right ◽  
Thalamic Region

PURPOSE: pineal region tumors are uncommon, and comprise more frequently three categories: germ cell, parenchymal cell and glial tumors. Most pineal gliomas are low-grade astrocytomas. Glioblastoma multiforme, the most aggressive and common brain tumor, is extremely rare at this location with only few cases reported. CASE DESCRIPTION: a 29-year-old woman with a two month history of headache, nuchal pain, fever, nausea and seizures and physical examination showing nuchal rigidity, generalized hypotony, hypotrophy and hyper-reflexia, Babinski sign and left VI cranial par palsy. CT scan examination revealed a ill-defined hypodense lesion at the pineal region with heterogeneous contrast enhancement. MRI showed a lesion at the pineal region infiltrating the right thalamic region. The patient underwent a right craniotomy with partial resection of the mass. The histological examination of paraffin-embedded material defined the diagnosis of glioblastoma multiforme. Post-operative radiotherapy was indicated but the patient refused the treatment and died two months afterwards. CONCLUSION: in spite of its rarity at this location, glioblastoma multiforme should be considered in the differential diagnosis of aggressive lesions at the pineal region.

Nasal Septal Hemangiopericytoma-like Tumor: A Case Report with an Immunohistochemical Study

2001 ◽  
Vol 15 (4) ◽  
pp. 267-270 ◽  
Author(s):  
Rie Yasui ◽  
Toru Minatogawa ◽  
Naoyuki Kanoh ◽  
Yasuo Nakata ◽  
Akira Kubota
Keyword(s):  
Case Report ◽  
Immunohistochemical Study ◽  
Preoperative Evaluation ◽  
Vascular Tumor ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
Topoisomerase Iiα ◽  
Ki 67 ◽  
Grade Malignancy ◽  
The Right

Nasal hemangiopericytoma-like (HPCL) tumor is a rare vascular tumor and should be differentiated from typical hemangiopericytomas (HPCs). This study reports the case of an HPCL tumor in a 77-year-old man with histological and immunohistochemical features. After preoperative evaluation of the blood supply, the dark-red right intranasal tumor was resected completely via the right maxillary sinus. The final histopathological diagnosis was HPCL tumor based on several stains: vimentin (+), α-SMA (+), etc. Moreover, there were few p53 (+) cells and the Ki-67 and topoisomerase IIα labeling indices were both under 5%. These findings indicated that this tumor was a low-grade malignancy. The immunohistochemical investigations used are useful for making the diagnosis of HPCL tumor and determining the treatment, malignancy, and prognosis. (American Journal of Rhinology 15 267–270, 2001)

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