scholarly journals Concurrence of thyrotoxicosis and Gitelman’s syndrome-associated hypokalemia-induced periodic paralysis

2012 ◽  
Vol 4 (2) ◽  
pp. 18 ◽  
Author(s):  
Shinsaku Imashuku ◽  
Tomoko Teramura-Ikeda ◽  
Naoko Kudo ◽  
Shigehiro Kaneda ◽  
Toshihiro Tajima
Keyword(s):  
Plasma Renin ◽  
High Plasma ◽  
Periodic Paralysis ◽  
Psychiatric Clinic ◽  
Homozygous Mutation ◽  
Gitelman's Syndrome ◽  
Asian Men ◽  
Old Japanese ◽  
History Of ◽  
Solute Carrier

A 16-year-old Japanese boy with a history of truancy had been treated at a psychiatric clinic. When the patient was referred to us for hypokalemia-associated paralysis, the diagnosis of thyrotoxic hypokalemic periodic paralysis was made, common in Asian men. Subsequently, the patient was found to have persistently high plasma renin and aldosterone levels. Thus, solute carrier family 12 member 3 gene (<em>SLC12A3</em>) analysis was performed. A novel missense homozygous mutation CTC-&gt;CAC at codon 858 (L858H) was found for which the patient was homozygous and his non-consanguineous parents heterozygote. These findings indicated that the patient developed hypokalemia-associated paralysis concurrently with thyrotoxicosis and Gitelman’s syndrome. This case underscores the importance of careful examinations of adolescents with complaints of truancy as well as of precise determinations of the causes of hypokalemia-associated paralysis.

The Natural History of Hypertension in Turkeys

1978 ◽  
Vol 55 (s4) ◽  
pp. 213s-215s ◽  
Author(s):  
A. Pagnan ◽  
A. C. Pessina ◽  
G. Thiene ◽  
C. Dal Palù
Keyword(s):  
Natural History ◽  
Salt Intake ◽  
Pathological Finding ◽  
Plasma Renin ◽  
High Plasma ◽  
Plasma Aldosterone ◽  
Atherosclerotic Plaques ◽  
High Salt Intake ◽  
History Of ◽  
High Concentrations

1. Variables involved in the genesis of hypertension in male broad-breasted white turkeys include social environment, obesity and high salt intake. 2. The hypertension is characterized by low plasma renin activity and, with increasing age, normal to high plasma aldosterone. 3. Medionecrosis of the abdominal aorta is a common pathological finding. 4. The absence of atherosclerotic plaques is probably related to the high concentrations of alpha-lipoproteins.

scholarly journals The Temporomandibular Joint in a Rheumatoid Arthritis Patient after Orthodontic Treatment

2009 ◽  
Vol 79 (4) ◽  
pp. 804-811 ◽  
Author(s):  
Kenichi Sasaguri ◽  
Rika Ishizaki-Takeuchi ◽  
Sakurako Kuramae ◽  
Eliana Midori Tanaka ◽  
Takashi Sakurai ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mouth Opening ◽  
Pharmacological Therapy ◽  
Open Bite ◽  
Anterior Open Bite ◽  
Orthodontic Therapy ◽  
Japanese Female ◽  
Severe Erosion ◽  
Old Japanese ◽  
History Of

Abstract A 32-year-old Japanese female patient consulted the authors' dental clinic with a 4.5-year history of rheumatoid arthritis (RA). She complained of pain during mouth opening and difficulty in eating due to masticatory dysfunction caused by an anterior open bite. Imaging showed severe erosion and flattening of both condyles. RA stabilized after pharmacological therapy and became inactive during the orthodontic therapy aimed at reconstructing an optimal occlusion capable of promoting functional repositioning of the mandible. At present, 4 years and 2 months postretention, the reconstructed occlusion remains stable, and both condyles continue to be remodeled. The distance from reference position to intercuspal position has gradually decreased throughout the 4-year posttreatment and postretention periods. Orthodontic therapy that comprehensively reconstructs occlusion and enhances the functioning of the mandible can induce remodeling of eroded condyles, even those with a history of rheumatoid arthritis.

scholarly journals Multiple-System Atrophy in Long-Term Professional Painter: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Yusa Nagai ◽  
Riko Kitazawa ◽  
Miku Nakagawa ◽  
Munenori Komoda ◽  
Takeshi Kondo ◽  
...  
Keyword(s):  
Multiple System Atrophy ◽  
Medulla Oblongata ◽  
Neurodegenerative Disorder ◽  
Histopathological Examination ◽  
Neuronal Loss ◽  
Cytoplasmic Inclusion ◽  
Multiple Organ ◽  
Old Japanese ◽  
History Of

Introduction. Multiple system atrophy (MSA) is a rare and severe adult-onset, sporadic, and progressive neurodegenerative disorder. Here, we describe an autopsy case of MSA in a long-term professional painter. Although typical glial cytoplasmic inclusion (GCI) was not observed in a routine histological examination, strong α-synuclein immunostaining in the nucleus confirmed the diagnosis of MSA.Case Presentation. A 48-year-old Japanese man with a long occupational history of professional painter was sent to the emergency room, where he died of multiple organ failure. The patient had suffered tremors and inarticulateness at age 28, developed diabetes at 42 and was diagnosed with spinocerebellar degeneration at 46. A histopathological examination showed severe neuronal loss, gliosis, and tissue rarefaction in the paleostriatum, striate body of the substantia nigra, the pons, and the olivary nucleus of the upper medulla oblongata, intermediolateral of the spinal gray matter (sacral region). α-synuclein-positive GCI in oligodendroglia was occurred in the cerebral cortex, the midbrain, the medulla oblongata, and the spinal cord. These findings confirmed the presence of multiple-system atrophy (OPCA+SDS).Conclusion. Although the pathogenesis of MSA is still unclear, prolonged, and extensive exposure to organic solvents, together with a hyperglycemic morbidity attributed to diabetes, may have contributed to the onset and clinical course of the present case.

scholarly journals A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Andrew Chu ◽  
Thu Thu Aung ◽  
Minni Shreya Arumugam ◽  
Mauricio Danckers ◽  
Mohi Mitiek ◽  
...  
Keyword(s):  
Oral Anticoagulants ◽  
Single Point ◽  
Factor V Leiden ◽  
Single Point Mutation ◽  
Homozygous Mutation ◽  
Factor V ◽  
Right Heart ◽  
Blood Clots ◽  
History Of ◽  
In Transit

Factor V Leiden (FVL) is an autosomal dominant condition resulting in thrombophilia. Factor V normally acts as a cofactor for prothrombinase, helping cleave prothrombin to thrombin. A single point mutation in it disrupts factor V, making it unreceptive to protein C and increasing the risk of thrombosis. FVL mutation associated with right heart thrombus is a rare entity. Right heart thrombus or right heart thrombus-in-transit is associated with high mortality. We present a 51-year-old male with a past medical history of FVL homozygous mutation and recurrent blood clots, who has failed multiple different oral anticoagulants. He presented to the hospital with symptoms of shortness of breath and subsequently found to have a giant right heart thrombus. He was treated with surgical embolectomy. This case underscores the challenges faced by patients with FVL and recurrent blood clots.

scholarly journals Study of incidence and prevalence of hypokalemic periodic paralysis

2019 ◽  
Vol 7 (3) ◽  
pp. 810
Author(s):  
Ajith Dungdung ◽  
Vishwanath Malkappa Jalawadi ◽  
Upendra Prasad Yadav
Keyword(s):  
Tertiary Care ◽  
Medical Science ◽  
Periodic Paralysis ◽  
High Carbohydrate Diet ◽  
Strenuous Exercise ◽  
Hypokalemic Periodic Paralysis ◽  
Tertiary Care Centre ◽  
Carbohydrate Diet ◽  
High Carbohydrate ◽  
History Of

Background: Hypokalemic periodic paralysis (HPP) is a rare autosomal dominant channelopathy characterised by muscle weakness or paralysis when there is a fall of potassium level in the blood. In individuals with mutation, attack begins during adolescents and most commonly occurs after sleep on awakening, rest after strenuous exercise, high carbohydrate diet and meal with high sodium content. This study was conducted to analyse the age of incidence and prevalence of HPP with various clinical presentations, diagnosis and its effective treatment.Methods: A retrospective analysis of 50 patients of Hypokalemic periodic paralysis was analysed in tertiary care centre “Rajendra institute of medical science” Ranchi, Jharkhand, India, with reference to its clinical presentation, age of incidence and prevalence with laboratory parameters and treatment outcomes.Results: Incidence of attack is more common in men between 26-35 years of age. Sudden onset of flaccid quadriparesis was the most common presentation with history of high carbohydrate diet on the background of strenuous work during summer season. Around 60% had similar history of attacks in the past and most of the patients had serum potassium levels between 2.1-3.0mEq/L. Electrocardiography (ECG) abnormalities associated with hypokalemia had been observed in 90% of patients, and also significant clinical, biochemical changes have been observed as well.Conclusions: Early diagnosis not only helps in definitive management with potassium replacement, but also prevents patient going for life threatening respiratory failure.  Patients recover completely without any clinical sequelae. Therefore, it is imperative for physicians, particularly those working in acute care settings, to be aware of this condition. Further management depends on the cause, frequency of attacks, severity of symptoms and the duration of the illness.

scholarly journals Case of Periodic Oculomotor Nerve Palsy

2020 ◽  
Vol V (1) ◽  
pp. 107-114
Author(s):  
G. A. Klyachkin
Keyword(s):  
Nerve Palsy ◽  
Russian Literature ◽  
Periodic Paralysis ◽  
Oculomotor Nerve ◽  
Oculomotor Nerve Palsy ◽  
Foreign Literature ◽  
History Of

Periodically recurring paralysis of the oculomotor nerve (migraine ophthalmoplegique French authors) is not often observed. In foreign literature, I managed to collect 24 cases, and in Russian literature, as far as I know, there is only one observation by prof. L.O.Darkshevich. In view of this, I think it is interesting to give a brief history of the illness of one patient, in whom, during the last day, I observed periodic paralysis of the oculomotor nerve

scholarly journals  Atresia coli in a Japanese black calf diagnosed by a barium sulphate enema contrast radiograph in the standing position: a case report

2012 ◽  
Vol 57 (No. 7) ◽  
pp. 376-379
Author(s):  
K. Abouelnasr ◽  
M. Ishii ◽  
H. Inokuma ◽  
Y. Kobayashi ◽  
K. Lee ◽  
...  
Keyword(s):  
Small Intestine ◽  
Case Report ◽  
Abdominal Distension ◽  
Standing Position ◽  
Barium Sulphate ◽  
Radiographic Examination ◽  
Anal Opening ◽  
Old Japanese ◽  
History Of ◽  
Colon And Rectum

A three day-old Japanese black calf was admitted with a history of abdominal distension and absence of defecation. Dilated loops of the small intestine and hypoplasia of the colon and rectum was observed upon a contrast radiographic examination in the standing position. At necropsy atresia coli with undeveloped rectum and patent anal opening was found. We conclude that a contrast radiograph in the standing position is useful for diagnosing atresia coli in such cases. &nbsp;

Influence of converting-enzyme inhibition on rat des-angiotensin I-angiotensinogen

1984 ◽  
Vol 246 (2) ◽  
pp. E129-E133 ◽  
Author(s):  
E. Clauser ◽  
J. Bouhnik ◽  
M. F. Gonzalez ◽  
P. Corvol ◽  
J. Menard
Keyword(s):  
Plasma Levels ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
High Plasma ◽  
Angiotensin I ◽  
Converting Enzyme Inhibition ◽  
The Difference ◽  
Indirect Assay ◽  
Captopril Treatment ◽  
Adrenalectomized Rats

The effects of high plasma renin levels on plasma levels of both total immunoreactive angiotensinogen (direct radioimmunoassay) and intact angiotensinogen measured by angiotensin I released by renin (indirect assay) were studied in sodium-depleted rats both with and without captopril treatment and in adrenalectomized rats. The direct assay measures both intact angiotensinogen and des-angiotensin I-angiotensinogen, its residue cleaved by renin. The indirect assay measures only intact angiotensinogen. Neither sodium depletion, captopril treatment, nor adrenalectomy modified the circulating levels of total angiotensinogen. However these treatments produced a decrease in intact angiotensinogen that was in proportion to the elevation of renin levels. The difference between the two assays for angiotensin represents the level of des-angiotensin I-angiotensinogen and correlated satisfactorily with the plasma levels of renin. Identical correlations were observed in adrenalectomized rats and captopril-treated rats. We conclude that des-angiotensin I-angiotensinogen levels are an index of activation of the renin-angiotensin system dependent on the circulating level of renin.

Progress of Psychiatry during 1913

1914 ◽  
Vol 60 (250) ◽  
pp. 516-519
Author(s):  
William McDonald
Keyword(s):  
Johns Hopkins Hospital ◽  
Psychiatric Clinic ◽  
American Psychiatry ◽  
History Of

On April 16th–18th, 1913, the Johns Hopkins Hospital, Baltimore, Maryland, opened the Henry Phipps Psychiatric Clinic. No event in the history of American psychiatry more justly deserved celebration, and none ever received more dignified and fitting observation. Scholars of world renown gathered from widely-separated parts to participate in the launching of the new enterprise. Practically the entire fifth number of vol. lxix of the American Journal of Insanity is devoted to the publication of the addresses delivered at the opening exercises, and every reader of the Journal of Mental Science would do well to review this remarkable collection of memoirs. There will be found a more complete and more authoritative résumé and retrospect of psychiatric progress than could possibly be conveyed in one or all of the annual letters of your correspondent.

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