Palatal stiffening via transoral, retrograde interstitial laser coagulation

Current treatment modalities for snoring may include mucosal removal, coblation or radiofrequency palatoplasty, injection snoreplasty and placement of palatal implants with described disadvantages. We introduce a new laser assisted method avoiding intraoral injury. A pilot study treating 13 loud snorers having an RDI<8 was conducted. A diode laser coupled to a flexible fiberand a handle with curved needle was used. The fiber was introduced into the nasal surface of soft palate between palatoglossal and glossopharyngeal arches and advanced progressively anteriorly after pulling the uvula forward three times to create palatal scarring and stiffening. All responded to a phone survey. Six patients reported significant improvement, 4 had some improvement, 2 had mild improvement and one patient had no change. Pain score was moderate for 3 patients while the rest had mild pain. The laser harbors many advantages over other methods. Results with this technique are encouraging further studies.

Download Full-text

Interstitial laser coagulation in the treatment of benign prostatic hyperplasia using a diode-laser system with temperature feedback

BJU International ◽

10.1046/j.1464-410x.1997.00369.x ◽

1997 ◽

Vol 80 (3) ◽

pp. 433-438 ◽

Cited By ~ 30

Author(s):

J.J.M.C.H. de la ROSETTE ◽

R. MUSCHTER ◽

M.A. LOPEZ ◽

D. GILLATT

Keyword(s):

Benign Prostatic Hyperplasia ◽

Diode Laser ◽

Laser System ◽

Prostatic Hyperplasia ◽

Laser Coagulation ◽

Temperature Feedback ◽

Interstitial Laser

Download Full-text

Interstitial laser coagulation in the treatment of benign prostatic hyperplasia using a diode laser system: results of an evolving technology

Prostate Cancer and Prostatic Diseases ◽

10.1038/sj.pcan.4500306 ◽

1999 ◽

Vol 2 (3) ◽

pp. 148-154 ◽

Cited By ~ 26

Author(s):

AC Mårtenson ◽

JJMCH de la Rosette

Keyword(s):

Benign Prostatic Hyperplasia ◽

Diode Laser ◽

Laser System ◽

Prostatic Hyperplasia ◽

Laser Coagulation ◽

Interstitial Laser

Download Full-text

1519: Long Term Outcome of Interstitial Laser Coagulation for Benign Prostatic Hyperplasia

The Journal of Urology ◽

10.1016/s0022-5347(18)33723-6 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 490-490

Author(s):

Stefan Zastrow ◽

Sven Oehlschläger ◽

Oliver W. Hakenberg ◽

Steffen Leike ◽

Manfred P. Wirth

Keyword(s):

Benign Prostatic Hyperplasia ◽

Prostatic Hyperplasia ◽

Laser Coagulation ◽

Term Outcome ◽

Long Term Outcome ◽

Interstitial Laser

Download Full-text

1567: Factors Associated with Failure of Interstitial Laser Coagulation in the Treatment of Benign Prostatic Hyperplasia

The Journal of Urology ◽

10.1016/s0022-5347(18)35701-x ◽

2005 ◽

Vol 173 (4S) ◽

pp. 424-425

Author(s):

Kenji Mitsumori ◽

Koji Nishizawa ◽

Takashi Kawahara ◽

Jun Watanabe ◽

Takashi Kobayashi ◽

...

Keyword(s):

Benign Prostatic Hyperplasia ◽

Prostatic Hyperplasia ◽

Laser Coagulation ◽

Factors Associated ◽

Interstitial Laser

Download Full-text

The Use of Mesenchymal Stem Cells and their Derived Extracellular Vesicles in Cardiovascular Disease Treatment

Current Stem Cell Research & Therapy ◽

10.2174/1574888x15666200501235201 ◽

2020 ◽

Vol 15 (7) ◽

pp. 623-638

Author(s):

Saeideh Gholamzadeh Khoei ◽

Fateme Karimi Dermani ◽

Sara Malih ◽

Nashmin Fayazi ◽

Mohsen Sheykhhasan

Keyword(s):

Cardiovascular Disease ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Extracellular Vesicles ◽

Adult Stem Cells ◽

Heart Diseases ◽

Therapeutic Option ◽

Current Treatment ◽

Treatment Modalities ◽

Cellular Source

Background: Cardiovascular disease (CVD), including disorders of cardiac muscle and vascular, is the major cause of death globally. Many unsuccessful attempts have been made to intervene in the disease's pathogenesis and treatment. Stem cell-based therapies, as a regeneration strategy, cast a new hope for CVD treatment. One of the most well-known stem cells is mesenchymal stem cells (MSCs), classified as one of the adult stem cells and can be obtained from different tissues. These cells have superior properties, such as proliferation and highly specialized differentiation. On the other hand, they have the potential to modulate the immune system and anti-inflammatory activity. One of their most important features is the secreting the extracellular vesicles (EVs) like exosomes (EXOs) as an intercellular communication system mediating the different physiological and pathophysiological affairs. Methods: In this review study, the importance of MSC and its secretory exosomes for the treatment of heart disease has been together and specifically addressed and the use of these promising natural and accessible agents is predicted to replace the current treatment modalities even faster than we imagine. Results: MSC derived EXOs by providing a pro-regenerative condition allowing innate stem cells to repair damaged tissues successfully. As a result, MSCs are considered as the appropriate cellular source in regenerative medicine. In the plethora of experiments, MSCs and MSC-EXOs have been used for the treatment and regeneration of heart diseases and myocardial lesions. Conclusions: Administration of MSCs has been provided a replacement therapeutic option for heart regeneration, obtaining great attention among the basic researcher and the medical doctors.

Download Full-text

Infective Aortic Valve Endocarditis Causing Embolic Consecutive ST-Elevation Myocardial Infarctions

Case Reports in Cardiology ◽

10.1155/2019/2487616 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5

Author(s):

Kanksha Peddi ◽

Alexander L. Hsu ◽

Tomas H. Ayala

Keyword(s):

Myocardial Infarction ◽

Infective Endocarditis ◽

Aortic Valve ◽

Index Case ◽

Current Treatment ◽

Myocardial Infarctions ◽

Treatment Modalities ◽

The Past ◽

First Case ◽

St Elevation

ST-elevation myocardial infarction (STEMI) is a rare and potentially fatal complication of infective endocarditis. We report the ninth case of embolic native aortic valve infective endocarditis causing STEMI and the first case to describe consecutive embolisms leading to infarctions of separate coronary territories. Through examination of this case in the context of the previous eight similar documented cases in the past, we find that infective endocarditis of the aortic valve can and frequently affect more than a single myocardial territory and can occur consecutively. Further, current treatment modalities for embolic infective endocarditis causing acute myocardial infarction are limited and unproven. This index case illustrates the potential severity of complications and the challenges in developing standardized management for such patients.

Download Full-text

Demonstration of Placental Vascular Anatomy in Monochorionic Twin Gestations

Pediatric and Developmental Pathology ◽

10.1007/s10024-001-0089-z ◽

2002 ◽

Vol 5 (1) ◽

pp. 37-44 ◽

Cited By ~ 35

Author(s):

Monique E. De Paepe ◽

Sarah Burke ◽

Francois I. Luks ◽

Halit Pinar ◽

Don B. Singer

Keyword(s):

Vascular Anatomy ◽

Treatment Modalities ◽

Laser Coagulation ◽

Injection Technique ◽

Invasive Treatment ◽

Monochorionic Twin ◽

Macroscopic Classification ◽

Fetoscopic Laser Coagulation

Invasive treatment modalities for severe chronic twin-to-twin transfusion syndrome (TTTS), such as fetoscopic laser coagulation of communicating vessels, have revived the need for detailed studies of placental angioar-chitecture. We describe a practical placental vascular injection technique using alcohol-resistant tissue-staining dyes. Injection of color-coded gelatin-dye mixtures effectively delineated the intertwin vasculature, and allowed unequivocal macroscopic classification of vascular communications as artery-to-artery, vein-to-vein, or deep artery–to-vein anastomoses. The existence of deep artery–to-vein anastomoses was further confirmed by light microscopic demonstration of venous dye of one twin and arterial dye of the opposite twin within the same stem villus. Furthermore, the injection technique allowed determination of the caliber of the anastomoses, the direction of the artery-to-vein anastomoses, and the relative vascular territory of each twin. Documenting the vascular communications in monochorionic twin placentas with and without TTTS may enhance our understanding of the pathogenesis of chronic TTTS. Correlating the anastomotic patterns and location of the laser coagulation scars with post-ablation outcome will aid in the design of rational therapeutic methods for this often lethal condition.

Download Full-text

Nonvisible Subthreshold Micropulse Diode Laser (810 nm) Treatment of Central Serous Chorioretinopathy: A Pilot Study

European Journal of Ophthalmology ◽

10.1177/112067210801800613 ◽

2008 ◽

Vol 18 (6) ◽

pp. 934-940 ◽

Cited By ~ 67

Author(s):

P. Lanzetta ◽

F. Furlan ◽

L. Morgante ◽

D. Veritti ◽

F. Bandello

Keyword(s):

Pilot Study ◽

Diode Laser ◽

Central Serous Chorioretinopathy

Download Full-text

Role of Vitamin D in the Prevention of Pancreatic Cancer

Journal of Nutrition and Metabolism ◽

10.1155/2010/721365 ◽

2010 ◽

Vol 2010 ◽

pp. 1-9 ◽

Cited By ~ 7

Author(s):

Pubudu Bulathsinghala ◽

Kostas N. Syrigos ◽

Muhammad W. Saif

Keyword(s):

Pancreatic Cancer ◽

Vitamin D ◽

Dietary Intake ◽

Sun Exposure ◽

Current Treatment ◽

Treatment Modalities ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

Advanced Stages

Pancreatic cancer is a malignancy of poor prognosis which is mostly diagnosed at advanced stages. Current treatment modalities are very limited creating great interest for novel preventive and therapeutic options. Vitamin D seems to have a protective effect against pancreatic cancer by participating in numerous proapoptotic, antiangiogenic, anti-inflammatory, prodifferentiating, and immunomodulating mechanisms. 25-hydroxyvitamin D [25(OH)D] serum concentrations are currently the best indicator of vitamin D status. There are three main sources of vitamin D: sun exposure, diet,and dietary supplements. Sun exposure has been associated with lower incidence of pancreatic cancer in ecological studies. Increased vitamin D levels seem to protect against pancreatic cancer, but caution is needed as excessive dietary intake may have opposite results. Future studies will verify the role of vitamin D in the prevention and therapy of pancreatic cancer and will lead to guidelines on adequate sun exposure and vitamin D dietary intake.

Download Full-text