Status Epilepticus Due to Severe HHV-6 Encephalitis in an Allogeneic Stem Cell Transplant Recipient

Reactivation of human herpes virus-6 (HHV-6) after stem cell transplantation occurs frequently. It is associated with clinical manifestations varying from nonspecific symptoms such as fevers or rash, to severe life threatening complications including post-transplantation limbic encephalitis. We report a case of severe HHV-6 encephalitis with viremia in an allogeneic peripheral stem cell transplant recipient who presented with status epilepticus unresponsive to antiepileptic therapy. With intravenous ganciclovir and supportive care, the patient’s condition improved. Awareness of HHV-6 infection in stem cell transplant recipients may help with early diagnosis and improved outcome.

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Deep Sequencing of Urine Specimens Detects Two BK Polyomavirus Genotypes in a Hematopoietic Stem Cell Transplant Recipient

Microbiology Resource Announcements ◽

10.1128/mra.01461-19 ◽

2020 ◽

Vol 9 (5) ◽

Author(s):

Trang Dinh Van ◽

Dominic E. Dwyer ◽

Neisha Jeoffreys ◽

Jen Kok ◽

Brian J. Nankivell ◽

...

Keyword(s):

Stem Cell ◽

Transplant Recipient ◽

Hematopoietic Stem Cell ◽

Hematopoietic Stem Cell Transplant ◽

Stem Cell Transplant ◽

Cell Transplant ◽

Transplant Recipients ◽

Genotype I ◽

Hematopoietic Stem ◽

Bk Polyomavirus

BK polyomavirus (BKPyV) is an important pathogen in transplant recipients. We report four draft BKPyV genomes, three of BKPyV genotype I (subtype I-b2) (AUS-105, AUS-106, and AUS-108) and one of genotype II (AUS-107). These draft genomes were identified in longitudinal urine samples collected from a single hematopoietic stem cell transplant recipient.

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Aseptic Meningitis after Recovery from SARS-CoV-2 in an Allogeneic Stem Cell Transplant Recipient

Clinical Medicine Insights Case Reports ◽

10.1177/11795476211009811 ◽

2021 ◽

Vol 14 ◽

pp. 117954762110098

Author(s):

Fahmin Basher ◽

Jose F Camargo ◽

Meilin Diaz-Paez ◽

Lazaros J Lekakis ◽

Denise L Pereira

Keyword(s):

Stem Cell ◽

Transplant Recipient ◽

Aseptic Meningitis ◽

Stem Cell Transplant ◽

Clinical Manifestations ◽

Respiratory Illness ◽

Cell Transplant ◽

Hematopoietic Stem ◽

Fluid Analysis ◽

Organ Systems

SARS-CoV-2 emerged as a worldwide pandemic in late 2019 and initially was described as a primary respiratory illness. The clinical manifestations of COVID-19 are now known to encompass nearly all organ systems, including the central nervous system. We present a case of an allogeneic hematopoietic stem cell transplant recipient who recovered from documented SARS-CoV-2 infection and later presented with symptoms of meningitis. While cerebrospinal fluid analysis did not reveal any bacterial or viral etiologies, evidence of an inflammatory state, including ophthalmologic findings of episcleritis, indicate what is likely the first reported case of aseptic meningitis associated with SARS-CoV-2 infection after initial clinical recovery.

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Acute, life-threatening hypoglycemia associated with haloperidol in a hematopoietic stem cell transplant recipient

Bone Marrow Transplantation ◽

10.1038/sj.bmt.1705187 ◽

2005 ◽

Vol 37 (1) ◽

pp. 109-110 ◽

Cited By ~ 6

Author(s):

R B Walter ◽

A N Hoofnagle ◽

S A Lanum ◽

S J Collins

Keyword(s):

Stem Cell ◽

Transplant Recipient ◽

Hematopoietic Stem Cell ◽

Hematopoietic Stem Cell Transplant ◽

Stem Cell Transplant ◽

Cell Transplant ◽

Hematopoietic Stem ◽

Life Threatening

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DAS181 Treatment of Severe Parainfluenza Virus 3 Pneumonia in Allogeneic Hematopoietic Stem Cell Transplant Recipients Requiring Mechanical Ventilation

Case Reports in Medicine ◽

10.1155/2016/8503275 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 7

Author(s):

B. Dhakal ◽

A. D’Souza ◽

M. Pasquini ◽

W. Saber ◽

T. S. Fenske ◽

...

Keyword(s):

Stem Cell ◽

Hematopoietic Stem Cell ◽

Hematopoietic Stem Cell Transplant ◽

Stem Cell Transplant ◽

Parainfluenza Virus ◽

Cell Transplant ◽

Transplant Recipients ◽

Hematopoietic Stem ◽

Life Threatening ◽

Type 3

Parainfluenza virus (PIV) may cause life-threatening pneumonia in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Currently, there are no proven effective therapies. We report the use of inhaled DAS181, a novel sialidase fusion protein, for treatment of PIV type 3 pneumonia in two allogeneic hematopoietic SCT recipients with respiratory failure.

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