scholarly journals Treatment of relapsed/refractory CLL with Venetoclax-Rituximab during the COVID-19 pandemic: A daily-life experience in southern Italy.

2021 ◽  
Vol 13 (1) ◽  
pp. e2021042
Author(s):  
Stefano Molica ◽  
Paolo Sportoletti ◽  
Nicola Di Renzo ◽  
Pellegrino Musto ◽  
Fabrizio Pane ◽  
...  
Keyword(s):  
Health Care ◽  
High Risk ◽  
Chronic Lymphocytic Leukaemia ◽  
Health Care Professionals ◽  
Southern Italy ◽  
Life Experience ◽  
Lymphocytic Leukaemia ◽  
Daily Life ◽  
Immune Defects ◽  
Haematologic Malignancies

With more than 3 million proven infections and 100.000 associated deaths in Italy, the COVID-19 pandemic poses extraordinary challenges to health-care professionals and especially to those caring for patients with haematologic malignancies  (1-2). Given the multiple   immune  defects characterizing chronic lymphocytic leukaemia (CLL), it is considered that patients with this form of leukemia have a high-risk of suffering severe forms of COVID-19 (3-4).

scholarly journals Safety and activity of ibrutinib plus rituximab for patients with high-risk chronic lymphocytic leukaemia: a single-arm, phase 2 study

2014 ◽  
Vol 15 (10) ◽  
pp. 1090-1099 ◽  
Author(s):  
Jan A Burger ◽  
Michael J Keating ◽  
William G Wierda ◽  
Elena Hartmann ◽  
Julia Hoellenriegel ◽  
...  
Keyword(s):  
High Risk ◽  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Phase 2 ◽  
Phase 2 Study

Frequency of Work Related Musculoskeletal Wrist Pain Among Health Care Professionals of Lahore Pakistan

2020 ◽  
pp. 35-39
Author(s):  
OJS Admin
Keyword(s):  
Health Care ◽  
High Risk ◽  
Health Care Professionals ◽  
Hard Work ◽  
Wrist Pain ◽  
Repetitive Movement ◽  
Work Related ◽  
Very High

The wrist and hand work related musculoskeletal (MSK) problems are very high in individuals performing prolonged hand task and repeated movements. The profession required manual dealing with additionally repetitive movement and hard work are at high risk of developing work related MSK problems.

Parents’, Health Care Professionals’, and Scientists’ Experiences of a Precision Medicine Pilot Trial for Patients With High-Risk Childhood Cancer: A Qualitative Study

2019 ◽  
pp. 1-11 ◽  
Author(s):  
Janine Vetsch ◽  
Claire E. Wakefield ◽  
Emily Duve ◽  
Brittany C. McGill ◽  
Meera Warby ◽  
...  
Keyword(s):  
Health Care ◽  
High Risk ◽  
Childhood Cancer ◽  
Precision Medicine ◽  
Health Care Professionals ◽  
New Technologies ◽  
Pilot Trial ◽  
Treatment Recommendations ◽  
Laboratory Research ◽  
Drug Access

PURPOSE Children with high-risk cancers have low survival rates because current treatment options are limited. Precision medicine trials are designed to offer patients individualized treatment recommendations, potentially improving their clinical outcomes. However, parents’ understanding is often limited, and expectations of benefit to their own child can be high. Health care professionals (HCPs) are often not familiar with precision medicine and might find managing families’ expectations challenging. Scientists find themselves working with high expectations among different stakeholders to rapidly translate their identification of actionable targets in real time. Therefore, we wanted to gain an in-depth understanding of the experiences of all stakeholders involved in a new precision medicine pilot trial called TARGET, including parents, their child’s HCPs, and the scientists who conducted the laboratory research and generated the data used to make treatment recommendations. METHODS We conducted semistructured interviews with all participants and analyzed the interviews thematically. RESULTS We interviewed 15 parents (9 mothers; 66.7% bereaved), 17 HCPs, and 16 scientists. We identified the following themes in parents’ interviews: minimal understanding and need for more information, hope as a driver of participation, challenges around biopsies, timing, and drug access, and few regrets. HCP and scientist interviews revealed themes such as embracing new technologies and collaborations and challenges managing families’ expectations, timing of testing and test results, and drug access. CONCLUSION Educating families, HCPs, and scientists to better understand the benefits and limitations of precision medicine trials may improve the transparency of the translation of discovery genomics to novel therapies, increase satisfaction with the child’s care, and ameliorate the additional long-term psychosocial burden for families already affected by high-risk childhood cancer.

Having Therapeutic Conversations With Fathers Grieving the Death of a Child

2019 ◽  
pp. 003022281982591
Author(s):  
Anne-Marie Martinez ◽  
Sonia Castiglione ◽  
France Dupuis ◽  
Alain Legault ◽  
Marie-Claude Proulx ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Professionals ◽  
Life Experience ◽  
Core Beliefs ◽  
Illness Beliefs ◽  
Death Of A Child ◽  
Child's Death ◽  
And Coping

A child’s death is a traumatic life experience for parents. Health-care professionals (HCPs) have sought guidance on how to intervene with grieving parents, particularly with fathers. Having therapeutic conversations is an effective way for HCPs to support grieving fathers. In our previous study, fathers identified core beliefs that influenced their experience of grief and coping. In this article, the Illness Beliefs Model was integrated with the findings to provide a framework for interventions to create open conversations, ease fathers’ suffering, and thereby help their spouse and family suffering as well. This article will guide HCPs to engage in therapeutic conversations to support bereaved fathers.

scholarly journals A TP53-mutáció-analízis jelentősége krónikus lymphocytás leukaemiában

2017 ◽  
Vol 158 (6) ◽  
pp. 220-228
Author(s):  
Viktória Fésüs ◽  
Dóra Marosvári ◽  
Béla Kajtár ◽  
Péter Attila Király ◽  
Judit Demeter ◽  
...  
Keyword(s):  
High Risk ◽  
Chronic Lymphocytic Leukaemia ◽  
Mutation Analysis ◽  
Sanger Sequencing ◽  
Tp53 Mutation ◽  
Lymphocytic Leukaemia ◽  
Tp53 Mutations ◽  
Risk Patients ◽  
Innovative Medicine ◽  
Made In

Abstract: Introduction: In recent years much progress has been made in the therapy of chronic lymphocytic leukaemia, as the new innovative medicine proved to be effective in managing patients carrying TP53 abnormalities. To identify all these patients, it is essential to screen for both forms of TP53 defects, including both 17p deletions and TP53 mutations. Aim: The aim of this study was to determine the frequency of TP53 mutations and their association with 17p deletions in a large Hungarian cohort of 196 patients suffering from chronic lymphocytic leukaemia. Method: We performed mutation analysis of TP53 (exons 3–10) using Sanger sequencing. Results: TP53 mutations were present in 15.8% of patients, half of which were associated with 17p deletion. By analysing both forms, TP53 defect was identified in 25.4% of the patients. Conclusions: Our study demonstrates that by performing a TP53 mutation analysis, an additional 10% of high-risk patients can be detected. Orv. Hetil., 2017, 158(6), 220–228.

scholarly journals A study on the knowledge, attitude and practice of medical students of a tertiary care teaching hospital on occupational hazards faced by the health care professionals

2017 ◽  
Vol 6 (12) ◽  
pp. 2931
Author(s):  
Pradumna Pathak ◽  
Raktim Borgohain
Keyword(s):  
Health Care ◽  
Medical Students ◽  
High Risk ◽  
Occupational Health ◽  
Health Care Professionals ◽  
Tertiary Care ◽  
Health Hazards ◽  
Working Environment ◽  
Occupational Hazards ◽  
Occupational Hazard

Background: Health care sector is clearly a high-risk sector for acquiring occupational hazards and have given rise to a debate on the need for a specific approach in order to improve the protection of the health and safety of hospital personnel. Many health care professionals in hospitals are exposed to significant occupational health hazards and consequently are at high risk of work-related diseases. This study aims to assess the knowledge, attitude, practice of medical students on occupational hazards faced by health care professionals.Methods: A cross-sectional study involving 235 undergraduate medical students was conducted using a semi-structured questionnaire.Results: All the respondents stated that they were aware of occupational hazard in their profession. 60% responded that biological hazards have maximum chance to occur at their working environment. 66.8% feared that occupational hazard can hamper their performance and 63.4% were of the view that animal simulation methods/manikins can minimize the risk of occupational hazard. 72.8% stated that clinical wards are the most likely place for occupational hazard and air-borne infection is the commonest source. Most respondents (97.4%) would like this topic to be included in the Undergraduate curriculum and 98.3% respondents were willing to attend a training programme about occupational health and safety.Conclusions: Hospital should provide personal protective equipment’s and look after adequate waste disposal systems to prevent the occurrence of health hazards in hospitals.

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