A Case-Control Study of Antidepressants and Attempted Suicide During Early Phase Treatment of Major Depressive Episodes

2008 ◽  
Vol 69 (3) ◽  
pp. 425-432 ◽  
Author(s):  
Mark Olfson ◽  
Steven C. Marcus
Keyword(s):  
Early Phase ◽  
Attempted Suicide ◽  
Case Control Study ◽  
Case Control ◽  
Major Depressive ◽  
Major Depressive Episodes ◽  
Depressive Episodes ◽  
Control Study

scholarly journals Temperament and character traits in major depressive disorder: a case control study

2017 ◽  
Vol 135 (5) ◽  
pp. 469-474 ◽  
Author(s):  
Barbara Schwair Nogueira ◽  
Renerio Fraguas Júnior ◽  
Isabela Martins Benseñor ◽  
Paulo Andrade Lotufo ◽  
Andre Russowsky Brunoni
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Case Control Study ◽  
Case Control ◽  
Character Traits ◽  
Major Depressive ◽  
Control Study

scholarly journals Suicide in Psychiatric Inpatients— A Case–Control Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Eberhard A. Deisenhammer ◽  
Elisa-Marie Behrndt-Bauer ◽  
Georg Kemmler ◽  
Christian Haring ◽  
Carl Miller
Keyword(s):  
Logistic Regression ◽  
Hospital Stay ◽  
Attempted Suicide ◽  
Case Control Study ◽  
Psychiatric Inpatients ◽  
Case Control ◽  
Increased Risk ◽  
Inpatient Suicide ◽  
History Of ◽  
Control Study

Objective: Psychiatric inpatients constitute a population at considerably increased risk for suicide. Identifying those at imminent risk is still a challenging task for hospital staff. This retrospective case–control study focused on clinical risk factors related to the course of the hospital stay.Method: Inpatient suicide cases were identified by linking the Tyrol Suicide Register with the registers of three psychiatric hospitals in the state. Control subjects were patients who had also been hospitalized in the respective psychiatric unit but had not died by suicide. Matching variables included sex, age, hospital, diagnosis, and admission date. The study period comprised 7 years. Data were analyzed by the appropriate two-sample tests and by logistic regression.Results: A total of 30 inpatient suicide cases and 54 control patients were included. A number of factors differentiated cases from controls; after correction for multiple testing, the following retained significance: history of aborted suicide, history of attempted suicide, history of any suicidal behavior/threats, suicidal ideation continuing during hospitalization, no development of prospective plans, no improvement of mood during the hospital stay, and leaving ward without giving notice. Logistic regression identified the latter three variables and history of attempted suicide as highly significant predictors of inpatient suicide.Conclusions: Preventive measures during hospitalization include thorough assessment of suicidal features, an emphasis on the development of future perspectives, and a review of hospital regulations for patients who want to leave the ward.

Risk factors for early-phase clozapine discontinuation: A nested case-control study

2021 ◽  
pp. 102745
Author(s):  
Mariko Tsukiji ◽  
Tsuyoshi Sasaki ◽  
Yusuke Nakata ◽  
Kiyomitsu Ota ◽  
Tsutomu Aoki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Early Phase ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Peripheral body temperature rhythm is associated with suicide risk in major depressive disorder: a case-control study

2021 ◽  
Vol 34 (1) ◽  
pp. e100219
Author(s):  
Xin Ma ◽  
Jing Cao ◽  
Hailin Zheng ◽  
Xinchun Mei ◽  
Meijuan Wang ◽  
...  
Keyword(s):  
Body Temperature ◽  
Suicide Risk ◽  
Case Control Study ◽  
Case Control ◽  
Phase Delay ◽  
Suicidal Risk ◽  
Major Depressive ◽  
Temperature Rhythm ◽  
Body Temperature Rhythm ◽  
Control Study

BackgroundPatients with major depressive disorder (MDD) may have an abnormal peripheral body temperature rhythm, but its relationship with suicidal risk and the response to treatment with antidepressants remain unknown.AimsThis study aimed to investigate the feature of peripheral body temperature in patients with MDD and its relationship with suicide risk before and after treatment with antidepressants.MethodsThis is a prospective case-control study. Patients diagnosed as MDD were enrolled into MDD group. Healthy subjects who matched in terms of gender, age and body mass index were enrolled into normal control (NC) group. The 24-hour peripheral body temperatures were monitored by TM’ Holter the next day after assessment. Patients with MDD were re-assessed after a 2-week treatment with antidepressants. All temperature data were fitted into cosine curves by Python.ResultThere were 41 patients with MDD, and 21 NC participants enrolled and completed the baseline assessments before the treatment. Patients with MDD were further divided into subgroup of with suicide risk or without suicide risk. In patients with MDD, the mesor of peripheral body temperature rhythm was higher in both patients with (36.17 (0.30)) and without suicide risk (36.22 (0.27)) than the mesor in NC participants before treatment (35.84 (0.38), Z=11.82, p=0.003, Kruskal-Wallis test). The phase-delay of temperature before treatment was greater in patients with MDD with suicidal risk (4.71 (1.68)) in comparison with those without suicidal risk (3.05 (2.19)) and NC participants (3.19 (1.82), Z=9.68, p=0.008, Kruskal-Wallis test). Moreover, phase-delay of temperature was associated with suicide risk in patients with MDD before treatment (OR=1.046, 95% CI: 1.009 to 1.085, p=0.015, unadjusted; OR=1.080, 95% CI: 1.020 to 1.144, p=0.009, adjusted by age and sex).ConclusionPatients with MDD might have abnormal peripheral body temperature. The abnormal phase-delay of peripheral body temperature may indicate suicide risk in patients with MDD, depending on validation in large-scale cohorts.

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