scholarly journals Hypermetabolism of basal ganglia in chorea associated with antiphospholipid antibodies demonstrated by F-18 FDG

1997 ◽  
Vol 2 (4) ◽  
pp. 14
Author(s):  
M. M. Sathekge ◽  
A. Maes ◽  
V. Thijst ◽  
M. De Roo
Keyword(s):  
Basal Ganglia ◽  
Antiphospholipid Syndrome ◽  
Cerebral Angiography ◽  
Fdg Pet ◽  
Antiphospholipid Antibodies ◽  
Brain Mri ◽  
Unknown Origin ◽  
Normal Brain ◽  
Primary Antiphospholipid Syndrome ◽  
The Brain

A brain FDG PET study was performed on a 21-year-old woman with subacute chorea of unknown origin. Associated with her chorea, she had abnormal levels of antiphospholipid antibodies. She had none of the classical features of SLE nor primary antiphospholipid syndrome. The images showed high F-18 FDG uptake in the basal ganglia, while the brain MRI and EEG were normal. An association between chorea and antiphospholipid antibodies had been demonstrated before, with normal brain CT, MRI, 123IMPSPECT and cerebral angiography. The report suggests the advantage of FDG PET in imaging of unexplained cases of chorea associated with antiphospholipid antibodies.

Long-term use of hydroxychloroquine reduces antiphospholipid antibodies levels in patients with primary antiphospholipid syndrome

2016 ◽  
Vol 65 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Entela Nuri ◽  
Mara Taraborelli ◽  
Laura Andreoli ◽  
Marta Tonello ◽  
Maria Gerosa ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Primary Antiphospholipid Syndrome

The clonal analysis of anticardiolipin antibodies in a single patient with primary antiphospholipid syndrome reveals an extreme antibody heterogeneity

Blood ◽  
2001 ◽  
Vol 97 (12) ◽  
pp. 3820-3828 ◽  
Author(s):  
Patricia Lieby ◽  
Anne Soley ◽  
Honey Levallois ◽  
Benedicte Hugel ◽  
Jean-Marie Freyssinet ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Polyclonal Antibodies ◽  
Single Cells ◽  
Expression System ◽  
Baculovirus Expression System ◽  
Clonal Analysis ◽  
Primary Antiphospholipid Syndrome ◽  
Single Patient ◽  
Prothrombotic State

The mechanism underlying the prothrombotic state that characterizes the primary antiphospholipid syndrome proves to be difficult to define mainly because of the variety of the phospholipid and protein targets of antiphospholipid antibodies that have been described. Much of the debate is related to the use of polyclonal antibodies during the different antiphospholipid assays. To better describe the antiphospholipid antibodies, a strategy was designed to analyze the reactivity of each one antibody making up the polyclonal anticardiolipin activity, breaking down this reactivity at the clonal level. This was performed in a single patient with primary antiphospholipid syndrome by combining (1) the antigen-specific selection of single cells sorted by flow cytometry using structurally bilayered labeled anionic phospholipids and (2) the cloning of immunoglobulin (Ig) variable (V) region genes originating from individual IgG anticardiolipin-specific B cells by a single-cell polymerase chain reaction technique. The corresponding V regions were cloned in order to express human recombinant antibodies in insect cells by a baculovirus expression system. The molecular analysis, the fine specificity, and the protein cofactor dependency of the first 5 monoclonal IgG anticardiolipins are reported here. This clonal analysis reveals the extreme heterogeneity of these antibodies, which could account for the difficulties in the previous attempts to define the pathogenic antiphospholipid response. This approach should help to unravel the complex antiphospholipid immune response and the mechanism of the prothrombotic state associated with these antibodies, but it could also shed some light on their possible origins.

scholarly journals Analysis on the MRI and BAEP  Results of Neonatal Brain with Different Levels of Bilirubin

2020 ◽  
Author(s):  
LU ZHONGXING ◽  
SHOULING DING ◽  
FEN WANG ◽  
Haitao Lv
Keyword(s):  
Central Nervous System ◽  
Brain Mri ◽  
Full Term ◽  
Normal Brain ◽  
Central Nervous System Damage ◽  
Severe Group ◽  
The Difference ◽  
The Brain ◽  
Abnormal Ratio ◽  
Abnormal Brain

Abstract Background：To explore whether there is abnormality of neonatal brains’ MRI and BAEP with different bilirubin levels, and to provide an objective basis for early diagnosis on the bilirubin induced subclinical damage on brains.Methods: To retrospectively analyze the clinical data of 103 neonatal patients, who had been hospitalized in Neonatology Department of Taicang First People’s Hospital from March 2013 to September 2015, to conduct routine brain MRI examination , BAEP testing and to analyze BAEP and MRI image results of the neonatal patients, who were divided into three groups based on the levels of total serum bilirubin concentration (TSB), 16 cases in mild group (TSB:0.0~229.0μmol/L), 49 cases in moderate group (TSB: 229.0~342.0μmol/L) and 38 cases in severe group (TSB≥342.0μmol/L); Results: We found as follows: A. Comparison of the bilirubin value of the different group : 1. The bilirubin value of the mild group is 171.99±33.50 μmol/L, the moderate group is293.98±32.09 μmol/L, and the severe group is 375.59±34.25 μmol /L . And the comparison of bilirubin values of the three groups of neonates (P＜0.01) indicates the difference is statistically significant (P＜0.01). 2. The bilirubin value of the pre-term group is 289.70±85.38μmol/Land the full-term group is 310.36±72.32 μmol/L, but the comparison of the bilirubin values between pre-term group and full-term group indicates that the difference is not statistically significant (P＞0.05).3. The bilirubin value of the normal brain MRI group(82) is 305.55±74.54 μmol/L and the abnormal brain MRI group is 303.56±83.04μmol/L; the comparison of bilirubin values between the two groups indicates that the difference is not statistically significant(P＞0.05). B. The weight value of the ﹤2500g group is 2.04±0.21 and the ≥2500ggroup is 3.39±0.46; the weight comparison of the two groups indicates that the difference is statistically significant (P＜0.01). C. Comparison of the abnormal MRI of the different groups: 1.The brain MRI result's abnormal ratio of the mild group is 31.25%, the moderate group is 16.33% and the severe group is 21.05%, but the comparison of brain MRI results of the three neonates groups indicates that the difference is not statistically significant (P＞0.05). 2.The brain MRI result's abnormal ratio of the pre-term is 30.77% and the full-term group is 16.88%, but the comparison of brain MRI results between prem-term group and full-term group indicates that the difference is not statistically significant (P＞0.05). 3.The brain MRI result's abnormal ratio of the ﹤2500g group is 37.50% and the ≥2500g group is 17.24%; but the comparison of brain MRI results of two neonates groups indicates that the difference is not statistically significant(P＞0.05). D. Comparison of abnormal MRI signal values of globus pallidus on T1WI in different groups: 1. The comparison of normal group signal values with that of mild group (p < 0.05), with that of moderate group and with that of severe group (p < 0.01) indicates that the difference is statistically significant; 2. The comparison of signal values between mild and moderate groups (p < 0.05) and between mild group and severe group (p < 0.01) indicates that the difference is statistically significant; 3. The comparison of signal values between moderate group and severe group indicates that the difference is statistically significant(p < 0.05). E. Comparison of BAEP testing results in groups: 1. There were 27(26.21%) cases in abnormalities of the BAEP results of all 103cases bilirubin patients. 2. There were 15(18.29%) cases in abnormalities of the BAEP result of the 82 cases normal brain MRL , 2(40%) cases in abnormalities of the BAEP result of the 5 cases abnormal MRI in mild bilirubin group, 4（50%） cases in abnormalities of the BAEP result of the 8 cases abnormal MRI in moderate bilirubin group and 6（75%）cases in abnormalities of the BAEP result of the 8 cases abnormal brain MRI in severe bilirubin group. 3. After one month review of the BAEP result, there was 0（0.00%） abnormal case in the normal MRI and the mild group; there were 1（20%） abnormal case in the moderate group and 2（25%） cases in the severe group. Conclusion: At low level of bilirubin, central nervous system damage may also occur and can be detected as abnormality by MRI and BAEP. Meanwhile, MRI and BAEP can also provide early abnormal information for the judgment of central nervous system damage of the children with NHB who have no acute bilirubin encephalopathy (ABE) clinical features, and provide clues for early treatment and early intervention.

scholarly journals The Recognition of Basal Ganglia Area in the Brain MRI Image with Hybrid Classifier

2017 ◽  
Vol 7 (1) ◽  
pp. 11-17
Author(s):  
Min-Chi Wu ◽  
◽  
Chiun-Li Chin ◽  
Wen-Chi Chin ◽  
Jian-Shiun Wu ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Brain Mri ◽  
Hybrid Classifier ◽  
The Brain ◽  
Mri Image

Coagulation Activation and Fibrinolytic imbalance in Subjects with Idiopathic Antiphospholipid Antibodies -A Crucial Role for Acquired Free Protein S Deficiency

1996 ◽  
Vol 76 (02) ◽  
pp. 190-194 ◽  
Author(s):  
Paul R J Ames ◽  
Catello Tommasino ◽  
Luigi Iannaccone ◽  
Massimo Brillante ◽  
Renato Cimino ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Thrombin Generation ◽  
Protein S ◽  
Venous Occlusion ◽  
Cross Sectional Study ◽  
Primary Antiphospholipid Syndrome ◽  
Cross Sectional ◽  
Free Protein ◽  
Asymptomatic Subjects

SummaryTo explore the coagulation/fibrinolytic balance and its relation with free protein S (f-PS) in subjects with antiphospholipid antibodies (aPLs) outside the setting of autoimmune inflammatory disorders, we carried out a cross-sectional study on 18 thrombotic patients with primary antiphospholipid syndrome and 18 apparently healthy subjects with persistence of idiopathic aPLs. Prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT) and D-Dimer (D-D) were taken as markers of thrombin generation and fibrin turnover. Mean F1+2 levels were higher in thrombotic (p = 0.006) and non-thrombotic subjects (p = 0.0001) than in controls as were those of D-D (p <0.0001 and p = 0.003 respectively). TAT levels did not differ. Lower mean levels of f-PS were found in thrombotic (p = 0.0006) and non-thrombotic subjects (p = 0.002) than in controls. Within both groups, mean Fl+2 levels were higher in subjects who had low f-PS levels compared to those with normal f-PS levels (p = 0.01). Gender analysed data revealed blunted tPA release (venous occlusion test) in thrombotic females (from 16.80 ± 0.79 to 21.3 ± 3.9 ng/nl, NS) but not in thrombotic males (from 18.2 ± 2.0 to 33.7 ± 4.9 ng/ml, p = 0.01) nor in asymptomatic subjects of either sex. Also, in both patient groups females had higher mean PAI than males (p <0.0002) and than control females (p <0.02). Low free protein S was found in 100% of non-thrombotic and in 90% of thrombotic patients with defective fibrinolysis. These data are consistent with increased thrombin generation, accelerated fibrin turnover and fibrinolysis abnormalities also in asymptomatic carriers of aPLs and highlight a central role for acquired f-PS deficiency in the thrombotic tendency of the antiphospholipid syndrome.

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