scholarly journals Effect of saturated fatty acid-rich dietary vegetable oils on lipid profile, antioxidant enzymes and glucose tolerance in diabetic rats

2010 ◽  
Vol 42 (3) ◽  
pp. 142 ◽  
Author(s):  
Kshama Devi ◽  
SantoshRaghunandan Fattepur ◽  
BensonMathai Kochikuzhyil
Keyword(s):  
Antioxidant Enzymes ◽  
Fatty Acid ◽  
Glucose Tolerance ◽  
Lipid Profile ◽  
Saturated Fatty Acid ◽  
Vegetable Oils ◽  
Diabetic Rats

Flavonoids Extracted from Asteriscus graveolens Improve Glucose Metabo-lism and Lipid Profile in Diabetic Rats

2020 ◽  
Vol 20 ◽  
Author(s):  
Fadwa El-ouady ◽  
Fatima Bachir ◽  
Mohamed Eddouks
Keyword(s):  
Glucose Tolerance ◽  
Lipid Profile ◽  
Histopathological Examination ◽  
Oral Treatment ◽  
Hdl Cholesterol ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Traditional Use ◽  
Soxhlet Apparatus

Aim: This study aimed to evaluate the antidiabetic and antihyperlipidemic effects of Asteriscus graveolens. Background: Asteriscus graveolens (Asteraceae) is a medicinal plant widely used by the Moroccan population to treat various diseases including diabetes. Objective: This work aimed to assess the capacity of flavonoids extracted from Asteriscus graveolens (FEE) to improve diabetes mellitus and dyslipidemia in normal and STZ-induced diabetic rats. Methods: Flavonoids were extracted from A. graveolens using the Soxhlet apparatus and using different organic solvents. Normal and streptozotocin-induced diabetic rats were treated orally by the extract of A. graveolens at a dose of 10 mg/kg. The oral treatment during 15 days was used to evaluate the effect of the flavonoids extracted from A. graveolens on blood glucose level and lipid profile in normal and diabetic rats. The oral glucose tolerance test as well as the analysis of histopathological examination of liver was performed. The antioxidant activity of FEE was also assessed by the method of trapping of free radical 2,2-diphenyl-1 picrylhydrazyl (DPPH), in order to estimate the mechanisms of action involved by FEE to improve hyperglycemia and lipid profile in normal and diabetic rats. Results: FEE reduced serum glucose concentrations in both normal and diabetic rats and exhibited in the last group lowering total cholesterol and triglycerides effects as well as improvement of the HDL-cholesterol serum level. In addition, a remarkable influence on glucose tolerance was also noticed after FEE treatment. Moreover, FEE was able to improve histopathological status of liver and possess a potential antioxidant effect in vitro. Conclusion: In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects of FEE in rats supporting then its traditional use for the management of diabetes.

Oxygen availability in brain tissues after lipid meals

1960 ◽  
Vol 198 (1) ◽  
pp. 217-220 ◽  
Author(s):  
Roy L. Swank ◽  
Haruomi Nakamura
Keyword(s):  
Body Weight ◽  
Fatty Acid ◽  
Saturated Fatty Acid ◽  
Vegetable Oils ◽  
Platinum Electrode ◽  
Saturated Fat ◽  
Oxygen Availability ◽  
Electrode Technique ◽  
Brain Tissues

The available oxygen in the hamster's brain was studied polarographically employing the platinum electrode technique. The electrodes were permanently implanted. After large lipid meals, the amount of oxygen available in the tissues was reduced. The reduction was greatest after cream and another highly saturated fat mixture. It was least after the very unsaturated oils, safflower and cod liver oils. Changes after olive, corn, cottonseed and other vegetable oils were intermediate. Cream meals containing as little as 0.9 gm of lipid/kg body weight produced significant reductions in the available oxygen in the tissues. Our studies suggest that the decrease in available oxygen in the tissues was due primarily to the amount of the saturated fatty acid in the lipid feeding.

Protective role of 20-OH ecdysone on lipid profile and tissue fatty acid changes in streptozotocin induced diabetic rats

2013 ◽  
Vol 698 (1-3) ◽  
pp. 489-498 ◽  
Author(s):  
Rajendran Naresh Kumar ◽  
Ramalingam Sundaram ◽  
Palanivelu Shanthi ◽  
Panchanatham Sachdanandam
Keyword(s):  
Fatty Acid ◽  
Lipid Profile ◽  
Protective Role ◽  
Diabetic Rats ◽  
Tissue Fatty Acid

scholarly journals Effect of Morus alba against Hyperglycemic and Hyperlipidemic Activities in Streptozotocin Induced Diabetic Nephropathy

2017 ◽  
Vol 14 (4) ◽  
pp. 1441-1447 ◽  
Author(s):  
P. Swathi ◽  
K. Gana Manjusha ◽  
M. Vivekanand ◽  
A. Ramkishan ◽  
B. Bhavani
Keyword(s):  
Antioxidant Enzymes ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Leaf Extract ◽  
Glycated Haemoglobin ◽  
Diabetic Rats ◽  
Morus Alba ◽  
Urine Protein ◽  
Ethanolic Leaf Extract ◽  
Level Profile

ABSTRACT: The present study was designed to investigate the antihyperglycemic and hypolipidemic activities of ethanolic leaf extract of Morus alba (EMA) in Streptozotocin induced diabetic rats. Blood glucose, serum parameters such as glycated haemoglobin (HbA1c), bilirubin, albumin, creatinine, total protein, urea, lipid profile, and urine parameters such as urine protein, creatinine and volume and renal antioxidant enzymes like SOD, CAT, GSH and MDA were estimated at the end of 12 weeks study period. Kidney histopathology was also done. The treatment with EMA showed significant (p<0.05) reduction in the elevated blood glucose, HbA1c, kidney function parameters and lipid profile in STZ induced diabetic rats. Treatment with EMA exerted improvement in antioxidant enzymes as SOD, CAT, GSH and reduction in MDA level profile in STZ induced diabetic rats. Histopathology reveals, EMA showed marked amelioration of glomerulosclerosis caused by STZ. The activities of Morus alba might be due to the presence of antioxidant principles like terpenoids and sterols.

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