scholarly journals Possible Role of Hydrogen Sulfide in Insulin Secretion and in Development of Insulin Resistance

2010 ◽  
Vol 2 (2) ◽  
pp. 148-151 ◽  
Author(s):  
M.A. Patel ◽  
G.B. Shah
Keyword(s):  
Insulin Resistance ◽  
Hydrogen Sulfide ◽  
Insulin Secretion

scholarly journals Adapting to insulin resistance in obesity: role of insulin secretion and clearance

Diabetologia ◽  
2017 ◽  
Vol 61 (3) ◽  
pp. 681-687 ◽  
Author(s):  
Sang-Hee Jung ◽  
Chan-Hee Jung ◽  
Gerald M. Reaven ◽  
Sun H. Kim
Keyword(s):  
Insulin Resistance ◽  
Insulin Secretion

Impairment of GLP1-induced insulin secretion: role of genetic background, insulin resistance and hyperglycaemia

2012 ◽  
Vol 14 ◽  
pp. 85-90 ◽  
Author(s):  
S. Herzberg-Schäfer ◽  
M. Heni ◽  
N. Stefan ◽  
H.-U. Häring ◽  
A. Fritsche
Keyword(s):  
Insulin Resistance ◽  
Insulin Secretion ◽  
Genetic Background

scholarly journals Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)

Metabolites ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 420
Author(s):  
Alexis C. Wood ◽  
Elizabeth T. Jensen ◽  
Alain G. Bertoni ◽  
Gautam Ramesh ◽  
Stephen S. Rich ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Evaluation Study ◽  
Disposition Index ◽  
Insulin Clearance ◽  
Relative Role ◽  
Operating Characteristics ◽  
Longitudinal Evaluation

Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while simultaneously examining decreased insulin sensitivity and secretion. The goal of this study was to conduct such an investigation in a cohort of 353 non-Hispanic White and African American individuals recruited in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). Participants underwent oral glucose tolerance tests from which insulin sensitivity, insulin secretion, insulin clearance, and disposition index were calculated. Regression models examined the individual and joint contributions of these traits to early dysglycemia (prediabetes or newly diagnosed diabetes). In separate models, reduced insulin sensitivity, reduced disposition index, and reduced insulin clearance were associated with dysglycemia. In a joint model, only insulin resistance and reduced insulin secretion were associated with dysglycemia. Models with insulin sensitivity, disposition index, or three insulin traits had the highest discriminative value for dysglycemia (area under the receiver operating characteristics curve of 0.82 to 0.89). These results suggest that in the race groups studied, insulin resistance and compromised insulin secretion are the main independent underlying defects leading to early dysglycemia.

scholarly journals ROLE OF PHYSICAL LOADS AND DRINKING MINERAL WATER IN PREVENTION AND TREATMENT OF OBESITY - BASIS OF METABOLIC SYNDROME

2017 ◽  
Vol 16 (5) ◽  
pp. 228-233
Author(s):  
Yu. B Barieva ◽  
L. A Botvineva ◽  
Agnessa Sardoevna Kaysinova ◽  
N. A Samsonova
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Insulin Secretion ◽  
Mineral Water ◽  
Healthy Lifestyle ◽  
Prevention And Treatment ◽  
Treatment Of Obesity

The review is devoted to the topical issues of non-pharmacological treatment of metabolic syndrome, namely, fight against hypodynamia (the mechanism of sanogenetic action of Scandinavian walking) and insulin resistance (the effect of drinking mineral water on normalization of insulin secretion). Non-medicamentous measures aimed at reducing body weight, changing dietary stereotypes, quiting bad habits such as smoking and alcohol abuse, increasing physical activity. These changes contribute to the formation of healthy lifestyle, they are highly effective, increase oxygenation of tissues, improve functional state of the cardiovascular and respiratory systems and have a pathogenetically directed effect on all links of metabolic syndrome: abdominal obesity, dyslipidemia, violation of carbohydrate metabolism, hyperinsulinemia, insulin resistance, sympaticotonia, arterial hypertension.

Role of miRNAs in the pathogenesis of T2DM, insulin secretion, insulin resistance, and β cell dysfunction: the story so far

2020 ◽  
Vol 76 (4) ◽  
pp. 485-502
Author(s):  
Prabhsimran Kaur ◽  
Sushil Kotru ◽  
Sandeep Singh ◽  
Bidwan Sekhar Behera ◽  
Anjana Munshi
Keyword(s):  
Insulin Resistance ◽  
Insulin Secretion ◽  
Β Cell ◽  
Cell Dysfunction

scholarly journals Role of Caveolin-1 in Diabetes and Its Complications

2020 ◽  
Vol 2020 ◽  
pp. 1-20 ◽  
Author(s):  
Dania Haddad ◽  
Ashraf Al Madhoun ◽  
Rasheeba Nizam ◽  
Fahd Al-Mulla
Keyword(s):  
Insulin Resistance ◽  
Signal Transduction ◽  
Insulin Secretion ◽  
Recent Progress ◽  
Principal Component ◽  
Integral Membrane Protein ◽  
Cholesterol Homeostasis ◽  
Cellular Functions ◽  
Caveolin 1

It is estimated that in 2017 there were 451 million people with diabetes worldwide. These figures are expected to increase to 693 million by 2045; thus, innovative preventative programs and treatments are a necessity to fight this escalating pandemic disorder. Caveolin-1 (CAV1), an integral membrane protein, is the principal component of caveolae in membranes and is involved in multiple cellular functions such as endocytosis, cholesterol homeostasis, signal transduction, and mechanoprotection. Previous studies demonstrated that CAV1 is critical for insulin receptor-mediated signaling, insulin secretion, and potentially the development of insulin resistance. Here, we summarize the recent progress on the role of CAV1 in diabetes and diabetic complications.

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